Article
Physiology
David C. -Y. Lu, Anke Hannemann, John S. Gibson
Summary: The presence of the bicarbonate/CO2 buffer system can significantly inhibit KCC activity in red cells, but this inhibition is not observed under low pH and high urea concentrations. The findings are important for understanding the function of sheep red cells and may also be relevant to abnormal red cells in other species and in patients with sickle cell disease.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tina Blazevic, Gottfried Reznicek, Limin Ding, Gangqiang Yang, Patricia Haiss, Elke H. Heiss, Verena M. Dirsch, Rongxia Liu
Summary: This study demonstrates that esterification is a promising approach to enhance the in vivo bioavailability of rosmarinic acid in rats and the in vitro biological activity in rat vascular smooth muscle cells. The optimal alkyl chain length for esterification is between C1 and C4, while longer alkyl chains may lead to cytotoxicity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Inchul You, Katherine A. Donovan, Noah M. Krupnick, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Eric S. Fischer, Eric S. Wang, Nathanael S. Gray
Summary: Recent interest has grown in the role of ERK5 in diseases like cancer and inflammation. However, current ERK5 inhibitors cannot replicate the effects of genetic loss of ERK5, suggesting its non-kinase roles. To explore this, researchers developed a potent and selective ERK5 degrader, INY-06-061. However, unlike genetic knockdown, its degradation of ERK5 did not have the expected effects in cancer cells or endothelial cells.
CELL CHEMICAL BIOLOGY
(2022)
Article
Cell Biology
Mengjie Guo, Pinggang Ding, Zhen Zhu, Lu Fan, Yanyan Zhou, Shu Yang, Ye Yang, Chunyan Gu
Summary: The study showed that elevated RFWD2 expression in MM patients leads to adverse outcomes and drug resistance. RFWD2 is involved in controlling cell cycle, growth and death in MM biology. Targeting RFWD2 may be an effective strategy to inhibit cellular proliferation and overcome drug resistance in MM.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Roxanne M. W. Banker, Jacob Lipovac, John J. Stachowicz, David A. Gold
Summary: Recent research has shown the important link between the environment, microbiome, and host fitness. This study investigates the role of sulfate-reducing bacteria in Pacific oyster shell formation and finds unexpected effects of sodium molybdate.
Article
Nutrition & Dietetics
Carlos Ruiz-Moreno, Francisco J. Amaro-Gahete, Jaime Gonzalez-Garcia, Veronica Giraldez-Costas, Asier Manas, Jorge Gutierrez-Hellin, Juan Del Coso
Summary: Ingesting caffeine before self-paced cycling can lead to higher self-selected exercise intensity and total work without impacting fat or carbohydrate oxidation during exercise.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Psychiatry
Elias Langeland, Ingvild Faxvaag Johnsen, Kaja Kastrup Somme, Arne Magnus Morken, Eilin Kristine Erevik, Eirin Kolberg, Jakob Jonsson, Rune Aune Mentzoni, Stale Pallesen
Summary: This study examined whether gambling loss limits should be income-specific and found that income does moderate empirically derived gambling loss limits. The lowest income group had the lowest loss limits, while the highest income group had the highest loss limits. Income-based gambling loss limits may have higher applied value for preventing gambling related harm compared to general loss limits.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Soil Science
Xueling Yang, Jing Yuan, Ningning Li, Ashley Edwin Franks, Jue Shentu, Yu Luo, Jianming Xu, Yan He
Summary: This study investigated the impact of microbial diversity loss on the degradation of gamma-HCH and methanogenesis by artificially manipulating the soil microbiome. The presence of gamma-HCH delayed methanogenesis while dilution intensified the coupling between gamma-HCH degradation and methanogenesis. Bacterial community was more affected by dilution compared to archaea.
SOIL BIOLOGY & BIOCHEMISTRY
(2021)
Review
Cell Biology
Samuel Klein, Amalia Gastaldelli, Hannele Yki-Jarvinen, Philipp E. Scherer
Summary: The accumulation of excessive body fat can lead to type 2 diabetes, and the risk of type 2 diabetes increases with an increase in body mass index. The global increase in obesity has therefore resulted in a corresponding increase in the prevalence of type 2 diabetes. The mechanisms linking obesity and type 2 diabetes involve complex changes in b cell function, adipose tissue biology, and multi-organ insulin resistance, which can be improved or even normalized through weight loss.
Article
Environmental Sciences
Haiqing Zhang, Qin Fang, Meng Li, Liangle Yang, Xuefeng Lai, Hao Wang, Meian He, Zhichao Wang, Weijia Kong, Xiaomin Zhang
Summary: This study aimed to investigate the association between hearing loss and all-cause and cardiovascular disease mortality, as well as the potential modification by chronic conditions in middle-aged and older Chinese adults. The results showed that hearing loss was independently associated with an increased risk of all-cause and CVD mortality, and the risk increased with the severity of hearing loss. Additionally, individuals with both hearing loss and diabetes or hypertension had a higher risk of mortality.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Veterinary Sciences
Maryam Moshref, Maria Questa, Veronica Lopez-Cervantes, Thomas K. Sears, Rachel L. Greathouse, Charles K. Crawford, Amir Kol
Summary: The passage discusses the challenges in efficiently reprogramming adult canine cells to induced pluripotent stem cells and the importance of histone acetylation and deacetylation in chromatin remodeling. It also mentions the use of HDAC inhibitors in somatic cell reprogramming.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Economics
Malgorzata Iwanicz-Drozdowska, Bartosz Witkowski
Summary: Post-GFC regulatory overhauls have significantly changed the banking industry environment. Uniform solutions for various banks may not be suitable for market realities, as different types and sizes of banks exhibit different patterns in profitability determinants.
JOURNAL OF POLICY MODELING
(2022)
Article
Endocrinology & Metabolism
Darya Dudenko, Raul Gomez, Miguel-Angel Garcia-Perez, Juan J. Tarin, Antonio Cano
Summary: The study revealed that Bazedoxifene has a proliferative effect similar to estradiol in cultured human umbilical artery endothelial cells, while the combination of Bazedoxifene and estradiol did not cause significant changes. Different compounds showed varying effects on cell proliferation at the expression level.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Surgery
Francesco Pizza, Dario D'Antonio, Juan Antonio Carbonell Asins, Francesco Saverio Lucido, Salvatore Tolone, Ludovico Docimo, Chiara Dell'Isola, Claudio Gambardella
Summary: This study retrospectively analyzed bariatric patients undergoing OAGB as revision surgery after experiencing weight regain and insufficient weight loss following SG. The results showed that OAGB as revision surgery after SG was effective in weight management and remission of comorbidities.
Article
Veterinary Sciences
Katarina Benova, Petr Dvorak, Dionyz Mate, Michaela Spalkova, Jana Dolezalova, Ladislav Kovarik
Summary: The experiment showed that there was a significant difference only in the meat color parameter (a*) in the irradiated group of pigs, suggesting that meat quality changes were minimal. If there is no internal contamination and the external radiation dose does not exceed 1 Gy, pigs from an irradiation-affected area may still be suitable for human consumption.
VETERINARNI MEDICINA
(2021)