The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties

Neutrophil Apoptosis: Selective Regulation by Different Ligands of Integrin  M 2

(2014) E. Pluskota et al.   JOURNAL OF IMMUNOLOGY

Structural Insight into the Function of Myelin Basic Protein as a Ligand for Integrin  M 2

(2014) R. Stapulionis et al.   JOURNAL OF IMMUNOLOGY

Intercellular Adhesion Molecule-3 Binding of Integrin  L 2 Requires Both Extension and Opening of the Integrin Headpiece

(2014) X.-Y. Tang et al.   JOURNAL OF IMMUNOLOGY

Transmigration of Neutrophils across Inflamed Endothelium Is Signaled through LFA-1 and Src Family Kinase

(2014) M. R. Sarantos et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of Leukocyte Transendothelial Migration

(2011) William A. Muller   Annual Review of Pathology-Mechanisms of Disease

The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes

(2011) R. Evans et al.   BLOOD

A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

(2011) Matthew MacPherson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures and Interaction Analyses of Integrin αMβ2 Cytoplasmic Tails

(2011) Geok-Lin Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins

(2011) H. Qu et al.   JOURNAL OF CELL SCIENCE

Cathepsin X cleavage of the  2 integrin regulates talin-binding and LFA-1 affinity in T cells

(2011) Z. Jevnikar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Leukocyte integrin αLβ2 transmembrane association dynamics revealed by coarse-grained molecular dynamics simulations

(2011) Choon-Peng Chng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Regulating neutrophil apoptosis: new players enter the game

(2011) Véronique Witko-Sarsat et al.   TRENDS IN IMMUNOLOGY

Molecular Architecture and Function of Matrix Adhesions

(2011) B. Geiger et al.   Cold Spring Harbor Perspectives in Biology

Molecular Dynamics Simulations of Forced Unbending of Integrin αVβ3

(2011) Wei Chen et al.   PLoS Computational Biology

Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils

(2010) Y. Kuwano et al.   BLOOD

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin  L 2-mediated slow leukocyte rolling

(2010) T. Yago et al.   BLOOD

RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo

(2010) D. Frommhold et al.   BLOOD

Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro

(2010) A. McDowall et al.   BLOOD

Human polymorphonuclear leucocytes stimulated by tumour necrosis factor-alpha show increased adherence to extracellular matrix proteins which is mediated via the CD11b/18 complex

(2010) H. L. THOMPSON et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

T Cell Receptor “Inside-Out” Pathway via Signaling Module SKAP1-RapL Regulates T Cell Motility and Interactions in Lymph Nodes

(2010) Monika Raab et al.   IMMUNITY

The Integrin Co-activator Kindlin-3 Is Expressed and Functional in a Non-hematopoietic Cell, the Endothelial Cell

(2010) Katarzyna Bialkowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recreation of the terminal events in physiological integrin activation

(2010) Feng Ye et al.   JOURNAL OF CELL BIOLOGY

The switchable integrin adhesome

(2010) R. Zaidel-Bar et al.   JOURNAL OF CELL SCIENCE

Rap1 controls activation of the αMβ2 integrin in a talin-dependent manner

(2010) Jenson Lim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Integrin  M 2 Clustering Triggers Phosphorylation and Activation of Protein Kinase C  that Regulates Transcription Factor Foxp1 Expression in Monocytes

(2010) Z.-H. Xue et al.   JOURNAL OF IMMUNOLOGY

A Transmembrane Polar Interaction Is Involved in the Functional Regulation of Integrin αLβ2

(2010) Ardcharaporn Vararattanavech et al.   JOURNAL OF MOLECULAR BIOLOGY

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The FERM domain: organizing the structure and function of FAK

(2010) Margaret C. Frame et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

(2010) Paul R. Elliott et al.   STRUCTURE

Understanding the Structure and Function of the Immunological Synapse

(2010) M. L. Dustin et al.   Cold Spring Harbor Perspectives in Biology

The Ins and Outs of Leukocyte Integrin Signaling

(2009) Clare L. Abram et al.   Annual Review of Immunology

CD11c Expression in Adipose Tissue and Blood and Its Role in Diet-Induced Obesity

(2009) Huaizhu Wu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of integrin activity and signalling

(2009) Carl G. Gahmberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners

(2009) Y. Ebisuno et al.   BLOOD

Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells

(2009) T. Quast et al.   BLOOD

Genetic etiologies of leukocyte adhesion defects

(2009) Amos Etzioni   CURRENT OPINION IN IMMUNOLOGY

Structure of an integrin with an αI domain, complement receptor type 4

(2009) Can Xie et al.   EMBO JOURNAL

The structure of the integrin αIIbβ3 transmembrane complex explains integrin transmembrane signalling

(2009) Tong-Lay Lau et al.   EMBO JOURNAL

Cathepsin X cleaves the β2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and α-actinin-1 binding

(2009) Zala Jevnikar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The β2 integrin CD11b attenuates polyinosinic:Polycytidylic acid-induced hepatitis by negatively regulating natural killer cell functions

(2009) Minggang Zhang et al.   HEPATOLOGY

Organization of proximal signal initiation at the TCR:CD3 complex

(2009) Clifford S. Guy et al.   IMMUNOLOGICAL REVIEWS

β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation

(2009) Nicholas J. Anthis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kindlin-1 and -2 Directly Bind the C-terminal Region of β Integrin Cytoplasmic Tails and Exert Integrin-specific Activation Effects

(2009) David S. Harburger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of an Interdomain Complex That Regulates Talin Activity

(2009) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New PI(4,5)P2- and membrane proximal integrin–binding motifs in the talin head control β3-integrin clustering

(2009) Frédéric Saltel et al.   JOURNAL OF CELL BIOLOGY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

The mechanical integrin cycle

(2009) E. Puklin-Faucher et al.   JOURNAL OF CELL SCIENCE

Integrins and cell-fate determination

(2009) C. H. Streuli   JOURNAL OF CELL SCIENCE

Src Homology 2-Domain Containing Leukocyte-Specific Phosphoprotein of 76 kDa Is Mandatory for TCR-Mediated Inside-Out Signaling, but Dispensable for CXCR4-Mediated LFA-1 Activation, Adhesion, and Migration of T Cells

(2009) J. Horn et al.   JOURNAL OF IMMUNOLOGY

Osteopontin Enhances Phagocytosis through a Novel Osteopontin Receptor, the  X 2 Integrin

(2009) L. Schack et al.   JOURNAL OF IMMUNOLOGY

The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation

(2009) Benjamin T. Goult et al.   JOURNAL OF MOLECULAR BIOLOGY

The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3

(2009) Jieqing Zhu et al.   MOLECULAR CELL

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

The Kindlin protein family: new members to the club of focal adhesion proteins

(2009) Alexander Meves et al.   TRENDS IN CELL BIOLOGY

Permissive transmembrane helix heterodimerization is required for the expression of a functional integrin

(2008) Ardcharaporn Vararattanavech et al.   BIOCHEMICAL JOURNAL

Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function

(2008) C. Shi et al.   BLOOD

LAD-1/variant syndrome is caused by mutations inFERMT3

(2008) Taco W. Kuijpers et al.   BLOOD

 2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

(2008) H. Takala et al.   BLOOD

α-Actinin structure and regulation

(2008) B. Sjöblom et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Disruption of the Integrin αLβ2 Transmembrane Domain Interface by β2 Thr-686 Mutation Activates αLβ2 and Promotes Micro-clustering of the αL Subunits

(2008) Ardcharaporn Vararattanavech et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Urokinase-type Plasminogen Activator Receptor Induces Conformational Changes in the Integrin αMβ2Headpiece and Reorientation of Its Transmembrane Domains

(2008) Man-Li Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR Solution Conformations and Interactions of Integrin αLβ2 Cytoplasmic Tails

(2008) Anirban Bhunia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Migfilin, a Molecular Switch in Regulation of Integrin Activation

(2008) Sujay Subbayya Ithychanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kindlin-2 (Mig-2): a co-activator of β3integrins

(2008) Yan-Qing Ma et al.   JOURNAL OF CELL BIOLOGY

Talin at a glance

(2008) D. R. Critchley et al.   JOURNAL OF CELL SCIENCE

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

(2008) Alexander Zarbock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RACK1 Regulates Directional Cell Migration by Acting on Gβγ at the Interface with Its Effectors PLCβ and PI3Kγ

(2008) Songhai Chen et al.   MOLECULAR BIOLOGY OF THE CELL

An Unusual Allosteric Mobility of the C-Terminal Helix of a High-Affinity αL Integrin I Domain Variant Bound to ICAM-5

(2008) Hongmin Zhang et al.   MOLECULAR CELL

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

(2008) Swapan K Nath et al.   NATURE GENETICS

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

(2008) Deborah K. Morrison   TRENDS IN CELL BIOLOGY