Protein deamidation in biopharmaceutical manufacture: understanding, control and impact
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Protein deamidation in biopharmaceutical manufacture: understanding, control and impact
Authors
Keywords
-
Journal
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
Volume 91, Issue 3, Pages 569-575
Publisher
Wiley
Online
2015-11-17
DOI
10.1002/jctb.4850
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cell culture media supplementation of bioflavonoids for the targeted reduction of acidic species charge variants on recombinant therapeutic proteins
- (2015) Patrick Hossler et al. BIOTECHNOLOGY PROGRESS
- Tailoring recombinant protein quality by rational media design
- (2015) David Brühlmann et al. BIOTECHNOLOGY PROGRESS
- Evaluation of capillary zone electrophoresis for charge heterogeneity testing of monoclonal antibodies
- (2015) Bernd Moritz et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Improving Trastuzumab’s Stability Profile by Removing the Two Degradation Hotspots
- (2015) Yuemei Yang et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Role of then+1 amino acid residue on the deamidation of asparagine in pentapeptides
- (2015) Hasan H. Ince et al. MOLECULAR PHYSICS
- Structural Characterisation of Non-Deamidated Acidic Variants of Erwinia chrysanthemi L-asparaginase Using Small-Angle X-ray Scattering and Ion-Mobility Mass Spectrometry
- (2015) David Gervais et al. PHARMACEUTICAL RESEARCH
- Capillary isoelectric focusing of a difficult-to-denature tetrameric enzyme using alkylurea–urea mixtures
- (2014) David Gervais et al. ANALYTICAL BIOCHEMISTRY
- Development and scale-up of a commercial fed batch refolding process for an anti-CD22 two chain immunotoxin
- (2014) Thomas Linke et al. BIOTECHNOLOGY PROGRESS
- Chromatographic and electrophoretic assessment of Filgrastim biosimilars in pharmaceutical formulations
- (2014) Eman L. Shaltout et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Recombinant Deamidated Mutants of Erwinia chrysanthemi l-Asparaginase Have Similar or Increased Activity Compared to Wild-Type Enzyme
- (2014) David Gervais et al. MOLECULAR BIOTECHNOLOGY
- Engineering deamidation-susceptible asparagines leads to improved stability to thermal cycling in a lipase
- (2014) K. Bhanuramanand et al. PROTEIN SCIENCE
- Estimation of the Deamidation Rates of Major Deamidation Sites in a Fab Fragment of Mouse IgG1-κ by Capillary Isoelectric Focusing of Mutated Fab Fragments
- (2013) Kiyohito Shimura et al. ANALYTICAL CHEMISTRY
- Static coatings for the analysis of intact monoclonal antibody drugs by capillary zone electrophoresis
- (2013) Anne-Laure Gassner et al. ELECTROPHORESIS
- Use of imaged capillary isoelectric focusing technique in development of diphtheria toxin mutant CRM197
- (2013) Richard R. Rustandi et al. ELECTROPHORESIS
- Developability studies before initiation of process development
- (2013) Xiaoyu Yang et al. mAbs
- Aggregation and Chemical Modification of Monoclonal Antibodies under Upstream Processing Conditions
- (2013) Stefan Dengl et al. PHARMACEUTICAL RESEARCH
- PRODUCTION, PURIFICATION, AND CHEMICAL STABILITY OF RECOMBINANT HUMAN INTERFERON-γ IN LOW OXYGEN TENSION CONDITION: A FORMULATION APPROACH
- (2013) Narges Malek-Sabet et al. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
- Control of process-induced asparaginyl deamidation during manufacture of Erwinia chrysanthemi l-asparaginase
- (2013) David Gervais et al. PROCESS BIOCHEMISTRY
- Quantitative Analysis of Deamidation and Isomerization in β2-Microglobulin by 18O Labeling
- (2012) Masafumi Fukuda et al. ANALYTICAL CHEMISTRY
- Determination of Deamidation Artifacts Introduced by Sample Preparation Using 18O-Labeling and Tandem Mass Spectrometry Analysis
- (2012) Yi Du et al. ANALYTICAL CHEMISTRY
- Regulation of Enzymatic Activity by Deamidation and Their Subsequent Repair by Protein l-isoaspartyl Methyl Transferase
- (2012) Trina Dutta et al. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
- Process scale separation of an anti-CD22 immunotoxin charge variant
- (2012) Thomas Linke et al. JOURNAL OF CHROMATOGRAPHY A
- Simultaneous Assessment of Asp Isomerization and Asn Deamidation in Recombinant Antibodies by LC-MS following Incubation at Elevated Temperatures
- (2012) Katharina Diepold et al. PLoS One
- Capillary electrophoresis-mass spectrometry using noncovalently coated capillaries for the analysis of biopharmaceuticals
- (2011) R. Haselberg et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Adsorption of deamidated antibody variants on macroporous and dextran-grafted cation exchangers: II. Adsorption kinetics
- (2011) Yinying Tao et al. JOURNAL OF CHROMATOGRAPHY A
- Adsorption kinetics of deamidated antibody variants on macroporous and dextran-grafted cation exchangers. III. Microscopic studies
- (2011) Yinying Tao et al. JOURNAL OF CHROMATOGRAPHY A
- Adsorption of deamidated antibody variants on macroporous and dextran-grafted cation exchangers: I. Adsorption equilibrium
- (2011) Yinying Tao et al. JOURNAL OF CHROMATOGRAPHY A
- Isolation and characterization of therapeutic antibody charge variants using cation exchange displacement chromatography
- (2011) Taylor Zhang et al. JOURNAL OF CHROMATOGRAPHY A
- Rapid analysis of charge variants of monoclonal antibodies with capillary zone electrophoresis in dynamically coated fused-silica capillary
- (2011) Yan He et al. JOURNAL OF SEPARATION SCIENCE
- Detection, Evaluation and Minimization of Nonenzymatic Deamidation in Proteomic Sample Preparation
- (2011) Piliang Hao et al. MOLECULAR & CELLULAR PROTEOMICS
- Post-translational modifications of protein biopharmaceuticals
- (2010) Gary Walsh DRUG DISCOVERY TODAY
- Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptides
- (2010) Hongqian Yang et al. ELECTROPHORESIS
- Validation of a pH gradient-based ion-exchange chromatography method for high-resolution monoclonal antibody charge variant separations
- (2010) Jennifer C. Rea et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Charge variants in IgG1
- (2010) Leslie A. Khawli et al. mAbs
- Multiproduct High-Resolution Monoclonal Antibody Charge Variant Separations by pH Gradient Ion-Exchange Chromatography
- (2009) Dell Farnan et al. ANALYTICAL CHEMISTRY
- Human antibody Fc deamidation in vivo
- (2009) Y. Diana Liu et al. BIOLOGICALS
- Changes in the quality of antibodies produced by Chinese hamster ovary cells during the death phase of cell culture
- (2009) Yoshihiro Kaneko et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- Method to Differentiate Asn Deamidation That Occurred Prior to and during Sample Preparation of a Monoclonal Antibody
- (2008) Georgeen Gaza-Bulseco et al. ANALYTICAL CHEMISTRY
- Application of imaging capillary IEF for characterization and quantitative analysis of recombinant protein charge heterogeneity
- (2008) Zoran Sosic et al. ELECTROPHORESIS
- Asparagine Deamidation and the Role of Higher Order Protein Structure
- (2008) Jenny Rivers et al. JOURNAL OF PROTEOME RESEARCH
- Post-translational Modifications of Recombinant Proteins: Significance for Biopharmaceuticals
- (2008) Nigel Jenkins et al. MOLECULAR BIOTECHNOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now