GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases

Characterization and Mechanism of Stress-induced Translocation of 78-Kilodalton Glucose-regulated Protein (GRP78) to the Cell Surface

(2015) Yuan-Li Tsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nexavar/Stivarga and Viagra Interact to Kill Tumor Cells

(2015) Mehrad Tavallai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease

(2015) Laurence Booth et al.   JOURNAL OF CELLULAR PHYSIOLOGY

OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies

(2015) Laurence Booth et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis

(2015) Y G Lin et al.   ONCOGENE

HSPA5 is an essential host factor for Ebola virus infection

(2014) St. Patrick Reid et al.   ANTIVIRAL RESEARCH

PDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells

(2014) Jane L Roberts et al.   CANCER BIOLOGY & THERAPY

DnaJ-Promoted Binding of DnaK to Multiple Sites on  32 in the Presence of ATP

(2014) A. Noguchi et al.   JOURNAL OF BACTERIOLOGY

Identification of Regulatory Elements That Control Expression of the tbpBA Operon in Neisseria gonorrhoeae

(2014) R. N. Velez Acevedo et al.   JOURNAL OF BACTERIOLOGY

Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress-Inducing Drugs

(2014) L. Booth et al.   MOLECULAR CANCER THERAPEUTICS

Getting RIDD of RNA: IRE1 in cell fate regulation

(2014) M. Maurel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Activation of the PKR/eIF2α signaling cascade inhibits replication of Newcastle disease virus

(2014) Shilei Zhang et al.   Virology Journal

Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice

(2013) Junfang Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells

(2013) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

The eIF2α kinases: their structures and functions

(2013) Neysan Donnelly et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis

(2013) R. Liu et al.   CLINICAL CANCER RESEARCH

GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN

(2013) W-T Chen et al.   ONCOGENE

IRE1: ER stress sensor and cell fate executor

(2013) Yani Chen et al.   TRENDS IN CELL BIOLOGY

Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation

(2013) Abhay P S Rathore et al.   Virology Journal

The Molecular Chaperone GRP78/BiP in the Development of Chemoresistance: Mechanism and Possible Treatment

(2013) Corinna Roller et al.   Frontiers in Pharmacology

Evaluation of PDE5 and PDE9 Expression in Benign and Malignant Breast Tumors

(2012) Fatemeh Karami-Tehrani et al.   ARCHIVES OF MEDICAL RESEARCH

OSU-03012 interacts with lapatinib to kill brain cancer cells

(2012) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing

(2012) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

Direct Binding and Regulation of RhoA Protein by Cyclic GMP-dependent Protein Kinase Iα

(2012) Mikio Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDE5 inhibitor promotes melanin synthesis through the PKG pathway in B16 melanoma cells

(2012) Xiaodong Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effects of low concentrations of Regorafenib and Sorafenib on human HCC cell AFP, migration, invasion, and growth in vitro

(2012) Brian I. Carr et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tadalafil crosses the blood–brain barrier and reverses cognitive dysfunction in a mouse model of AD

(2012) Carolina García-Barroso et al.   NEUROPHARMACOLOGY

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

(2012) B Luo et al.   ONCOGENE

dsRNA-Dependent Protein Kinase PKR and its Role in Stress, Signaling and HCV Infection

(2012) Stéphanie Dabo et al.   Viruses-Basel

New Insights into Translational Regulation in the Endoplasmic Reticulum Unfolded Protein Response

(2012) G. D. Pavitt et al.   Cold Spring Harbor Perspectives in Biology

Guanylyl cyclase structure, function and regulation

(2011) Lincoln R. Potter   CELLULAR SIGNALLING

Differential Expression of PDE5 in Failing and Nonfailing Human Myocardium

(2011) Xiaoyin Shan et al.   Circulation-Heart Failure

Nitric oxide: A regulator of eukaryotic initiation factor 2 kinases

(2011) Lingying Tong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phase I Pharmacokinetic and Pharmacodynamic Study of the Multikinase Inhibitor Sorafenib in Combination With Clofarabine and Cytarabine in Pediatric Relapsed/Refractory Leukemia

(2011) Hiroto Inaba et al.   JOURNAL OF CLINICAL ONCOLOGY

Cyclic di-GMP Activation of Polynucleotide Phosphorylase Signal-Dependent RNA Processing

(2011) Jason R. Tuckerman et al.   JOURNAL OF MOLECULAR BIOLOGY

Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen Species-Dependent Signaling Pathway

(2010) M. A. Park et al.   CANCER RESEARCH

Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells

(2010) Yukio Kimata et al.   CURRENT OPINION IN CELL BIOLOGY

Quantitation of sorafenib and its active metabolite sorafenib N-oxide in human plasma by liquid chromatography–tandem mass spectrometry

(2010) Lie Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78

(2010) Hai Yu et al.   JOURNAL OF MOLECULAR MODELING

A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias

(2010) K W Pratz et al.   LEUKEMIA

Identification of Essential Filovirion-associated Host Factors by Serial Proteomic Analysis and RNAi Screen

(2010) Kevin B. Spurgers et al.   MOLECULAR & CELLULAR PROTEOMICS

Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells

(2010) Margaret A. Park et al.   MOLECULAR CANCER THERAPEUTICS

Eradication of Intracellular Salmonella enterica Serovar Typhimurium with a Small-Molecule, Host Cell-Directed Agent

(2009) H.-C. Chiu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

OSU-03012 sensitizes TIB-196 myeloma cells to imatinib mesylate via AMP-activated protein kinase and STAT3 pathways

(2009) Li-Yuan Bai et al.   LEUKEMIA RESEARCH

BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing

(2009) A. P. Martin et al.   MOLECULAR PHARMACOLOGY

The function of NO-sensitive guanylyl cyclase: What we can learn from genetic mouse models

(2009) Andreas Friebe et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Type 5 phosphodiesterase expression is a critical determinant of the endothelial cell angiogenic phenotype

(2008) Bing Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model

(2008) Keith L. Black et al.   BRAIN RESEARCH

Targeting Endoplasmic Reticulum Stress and Akt with OSU-03012 and Gefitinib or Erlotinib to Overcome Resistance to Epidermal Growth Factor Receptor Inhibitors

(2008) Y.-C. Wang et al.   CANCER RESEARCH

OSU-03012, a Novel Celecoxib Derivative, Induces Reactive Oxygen Species-Related Autophagy in Hepatocellular Carcinoma

(2008) M. Gao et al.   CANCER RESEARCH

Protein Kinase G-dependent Cardioprotective Mechanism of Phosphodiesterase-5 Inhibition Involves Phosphorylation of ERK and GSK3β

(2008) Anindita Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OSU-03012 Stimulates PKR-Like Endoplasmic Reticulum-Dependent Increases in 70-kDa Heat Shock Protein Expression, Attenuating Its Lethal Actions in Transformed Cells

(2008) M. A. Park et al.   MOLECULAR PHARMACOLOGY