Nexavar/Stivarga and Viagra Interact to Kill Tumor Cells

PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types

(2015) Laurence Booth et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells

(2014) Jane L Roberts et al.   CANCER BIOLOGY & THERAPY

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

(2014) Nitai C Hait et al.   NATURE NEUROSCIENCE

Nitric oxide inhibits autophagy via suppression of JNK in meniscal cells

(2014) C. Shen et al.   RHEUMATOLOGY

Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy

(2013) Nichola Cruickshanks et al.   CANCER BIOLOGY & THERAPY

A Proposal Regarding Reporting of In Vitro Testing Results

(2013) M. A. Smith et al.   CLINICAL CANCER RESEARCH

Inhibition of autophagy and glycolysis by nitric oxide during hypoxia–reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons

(2013) Gloria A. Benavides et al.   FREE RADICAL BIOLOGY AND MEDICINE

P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway

(2013) Mandi Gandelman et al.   JOURNAL OF NEUROCHEMISTRY

Sildenafil Promotes eNOS Activation and Inhibits NADPH Oxidase in the Transgenic Sickle Cell Mouse Penis

(2013) Biljana Musicki et al.   Journal of Sexual Medicine

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

(2013) D. N. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Hepatoma Using Nitric Oxide Donor Strategies

(2012) Raúl González et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: Detection, oxidative damage and catalytic removal by Mn–porphyrins

(2012) Valeria Valez et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Nitric oxide (•NO) generation but not ROS plays a major role in silibinin-induced autophagic and apoptotic death in human epidermoid carcinoma A431 cells

(2012) Yang Yu et al.   FREE RADICAL RESEARCH

Effects of low concentrations of Regorafenib and Sorafenib on human HCC cell AFP, migration, invasion, and growth in vitro

(2012) Brian I. Carr et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nitric Oxide and Cyclic GMP Signaling Pathway as a Focus for Drug Development

(2011) A.Y. Kots et al.   CURRENT MEDICINAL CHEMISTRY

Phase I Pharmacokinetic and Pharmacodynamic Study of the Multikinase Inhibitor Sorafenib in Combination With Clofarabine and Cytarabine in Pediatric Relapsed/Refractory Leukemia

(2011) Hiroto Inaba et al.   JOURNAL OF CLINICAL ONCOLOGY

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation

(2010) Margaret A. Park et al.   CANCER BIOLOGY & THERAPY

Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen Species-Dependent Signaling Pathway

(2010) M. A. Park et al.   CANCER RESEARCH

Quantitation of sorafenib and its active metabolite sorafenib N-oxide in human plasma by liquid chromatography–tandem mass spectrometry

(2010) Lie Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias

(2010) K W Pratz et al.   LEUKEMIA

Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells

(2010) Margaret A. Park et al.   MOLECULAR CANCER THERAPEUTICS

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction

(2010) A. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concurrent targeting of nitrosative stress–PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathy

(2009) Geeta Negi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing

(2009) A. P. Martin et al.   MOLECULAR PHARMACOLOGY

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Type 5 phosphodiesterase expression is a critical determinant of the endothelial cell angiogenic phenotype

(2008) Bing Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model

(2008) Keith L. Black et al.   BRAIN RESEARCH

Protein Kinase G-dependent Cardioprotective Mechanism of Phosphodiesterase-5 Inhibition Involves Phosphorylation of ERK and GSK3β

(2008) Anindita Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY