PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types

PDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells

(2014) Jane L Roberts et al.   CANCER BIOLOGY & THERAPY

The discovery and development of cyclooxygenase-2 inhibitors as potential anticancer therapies

(2014) Mohsen Vosooghi et al.   Expert Opinion on Drug Discovery

Nitric oxide inhibits autophagy via suppression of JNK in meniscal cells

(2014) C. Shen et al.   RHEUMATOLOGY

Dolastatin, along with Celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation

(2013) Honit Piplani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy

(2013) Nichola Cruickshanks et al.   CANCER BIOLOGY & THERAPY

Enhanced apoptotic effects by downregulating Mcl-1: Evidence for the improvement of photodynamic therapy with Celecoxib

(2013) Jiaxing Song et al.   EXPERIMENTAL CELL RESEARCH

An update on pharmacological treatment of erectile dysfunction with phosphodiesterase type 5 inhibitors

(2013) Roberto Bruzziches et al.   EXPERT OPINION ON PHARMACOTHERAPY

Inhibition of autophagy and glycolysis by nitric oxide during hypoxia–reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons

(2013) Gloria A. Benavides et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sorafenib and HDAC inhibitors synergize with TRAIL to kill tumor cells

(2013) Hossein A. Hamed et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib

(2013) Robert Ramer et al.   JOURNAL OF LIPID RESEARCH

P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway

(2013) Mandi Gandelman et al.   JOURNAL OF NEUROCHEMISTRY

C22:0- and C24:0-dihydroceramides Confer Mixed Cytotoxicity in T-Cell Acute Lymphoblastic Leukemia Cell Lines

(2013) Michael W. Holliday Jr. et al.   PLoS One

Celecoxib-Induced Cytotoxic Effect Is Potentiated by Inhibition of Autophagy in Human Urothelial Carcinoma Cells

(2013) Kuo-How Huang et al.   PLoS One

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

(2013) D. N. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Hepatoma Using Nitric Oxide Donor Strategies

(2012) Raúl González et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of Sphingolipid Metabolism Enhances Resveratrol Chemotherapy in Human Gastric Cancer Cells

(2012) Kyong-Oh Shin et al.   Biomolecules & Therapeutics

OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing

(2012) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

Nitric oxide (•NO) generation but not ROS plays a major role in silibinin-induced autophagic and apoptotic death in human epidermoid carcinoma A431 cells

(2012) Yang Yu et al.   FREE RADICAL RESEARCH

Chemoprevention in familial adenomatous polyposis

(2011) Brian Kim et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Lung Cancer Chemoprevention with Celecoxib in Former Smokers

(2011) Jenny T. Mao et al.   Cancer Prevention Research

Celecoxib Promotes c-FLIP Degradation through Akt-Independent Inhibition of GSK3

(2011) S. Chen et al.   CANCER RESEARCH

Nitric Oxide and Cyclic GMP Signaling Pathway as a Focus for Drug Development

(2011) A.Y. Kots et al.   CURRENT MEDICINAL CHEMISTRY

Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide

(2010) Susanne Schiffmann et al.   BIOCHEMICAL PHARMACOLOGY

Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen Species-Dependent Signaling Pathway

(2010) M. A. Park et al.   CANCER RESEARCH

ERK/Ribosomal S6 Kinase (RSK) Signaling Positively Regulates Death Receptor 5 Expression through Co-activation of CHOP and Elk1

(2010) You-Take Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction

(2010) A. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Celecoxib prevents tumor growth in an animal model by a COX-2 independent mechanism

(2009) Amanda Leite Bastos-Pereira et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cytotoxic effects of celecoxib on Raji lymphoma cells correlate with aggravated endoplasmic reticulum stress but not with inhibition of cyclooxygenase-2

(2009) Szu-Ting Chen et al.   LEUKEMIA RESEARCH

The anti-proliferative potency of celecoxib is not a class effect of coxibs

(2008) Susanne Schiffmann et al.   BIOCHEMICAL PHARMACOLOGY

Aggravated Endoplasmic Reticulum Stress as a Basis for Enhanced Glioblastoma Cell Killing by Bortezomib in Combination with Celecoxib or Its Non-Coxib Analogue, 2,5-Dimethyl-Celecoxib

(2008) A. Kardosh et al.   CANCER RESEARCH

Selective COX2 inhibition improves whole body and muscular insulin resistance in fructose-fed rats

(2008) P.-S. Hsieh et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Protein Kinase G-dependent Cardioprotective Mechanism of Phosphodiesterase-5 Inhibition Involves Phosphorylation of ERK and GSK3β

(2008) Anindita Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro

(2008) Huan-Ching Chuang et al.   Molecular Cancer

N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing

(2008) H. Wang et al.   MOLECULAR CANCER THERAPEUTICS

OSU-03012 Stimulates PKR-Like Endoplasmic Reticulum-Dependent Increases in 70-kDa Heat Shock Protein Expression, Attenuating Its Lethal Actions in Transformed Cells

(2008) M. A. Park et al.   MOLECULAR PHARMACOLOGY

Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G

(2007) Jae-Won Soh et al.   MOLECULAR CARCINOGENESIS