Engineering clinically relevant volumes of vascularized bone

Vascularization Strategies for Bone Regeneration

(2014) Laxminarayanan Krishnan et al.   ANNALS OF BIOMEDICAL ENGINEERING

VEGF Receptor 2 (VEGFR2) Activation Is Essential for Osteocyte Survival Induced by Mechanotransduction

(2014) Luis F. de Castro et al.   JOURNAL OF CELLULAR PHYSIOLOGY

In Vivo Bioreactors for Mandibular Reconstruction

(2014) A.M. Tatara et al.   JOURNAL OF DENTAL RESEARCH

Mesenchymal Stem Cells: Roles and Relationships in Vascularization

(2014) Anthony J. Melchiorri et al.   TISSUE ENGINEERING PART B-REVIEWS

Use of Porous Space Maintainers in Staged Mandibular Reconstruction

(2014) Allan M. Henslee et al.   Oral and Maxillofacial Surgery Clinics of North America

The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen–glycosaminoglycan scaffold in vivo

(2013) T.M. McFadden et al.   Acta Biomaterialia

Reduction of connexin43 in human endothelial progenitor cells impairs the angiogenic potential

(2013) Hsueh-Hsiao Wang et al.   ANGIOGENESIS

Flow Perfusion Co-culture of Human Mesenchymal Stem Cells and Endothelial Cells on Biodegradable Polymer Scaffolds

(2013) Rebecca L. Dahlin et al.   ANNALS OF BIOMEDICAL ENGINEERING

Influence of Mesenchymal Stem Cells with Endothelial Progenitor Cells in Co-culture on Osteogenesis and Angiogenesis: An In Vitro Study

(2013) Qiong Li et al.   ARCHIVES OF MEDICAL RESEARCH

Prefabrication of a Vascularized Bone Graft With Beta Tricalcium Phosphate Using an In Vivo Bioreactor

(2013) Dong Han et al.   ARTIFICIAL ORGANS

Osteogenic graft vascularization and bone resorption by VEGF-expressing human mesenchymal progenitors

(2013) Uta Helmrich et al.   BIOMATERIALS

Shell-core bi-layered scaffolds for engineering of vascularized osteon-like structures

(2013) Xuening Chen et al.   BIOMATERIALS

The effect of mesenchymal stem cells delivered via hydrogel-based tissue engineered periosteum on bone allograft healing

(2013) Michael D. Hoffman et al.   BIOMATERIALS

Cooperation between osteoblastic cells and endothelial cells enhances their phenotypic responses and improves osteoblast function

(2013) Tuvd Dariima et al.   BIOTECHNOLOGY LETTERS

Induced periosteum a complex cellular scaffold for the treatment of large bone defects

(2013) Richard J. Cuthbert et al.   BONE

Molecular Mechanisms of Osteoblast/Osteocyte Regulation by Connexin43

(2013) Joseph P. Stains et al.   CALCIFIED TISSUE INTERNATIONAL

Effect of Aging on Metabolic Pathways in Endothelial Progenitor Cells

(2013) Francesca Felice et al.   CURRENT PHARMACEUTICAL DESIGN

Cell-based approaches to the engineering of vascularized bone tissue

(2013) Rameshwar R. Rao et al.   CYTOTHERAPY

Prevascularisation with endothelial progenitor cells improved restoration of the architectural and functional properties of newly formed bone for bone reconstruction

(2013) Hao Pang et al.   INTERNATIONAL ORTHOPAEDICS

Engineering bone tissue substitutes from human induced pluripotent stem cells

(2013) G. M. de Peppo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions of Mesenchymal Stem Cells with Endothelial Cells

(2013) Seyed Mahdi Nassiri et al.   STEM CELLS AND DEVELOPMENT

Vascular endothelial growth factor attachment to hydroxyapatite via self-assembled monolayers promotes angiogenic activity of endothelial cells

(2013) Kimberly D. Solomon et al.   THIN SOLID FILMS

Platelet-Derived Growth Factor and Spatiotemporal Cues Induce Development of Vascularized Bone Tissue by Adipose-Derived Stem Cells

(2013) Daphne L. Hutton et al.   TISSUE ENGINEERING PART A

Adipose-Derived Mesenchymal Stromal Cells From Aged Patients With Coronary Artery Disease Keep Mesenchymal Stromal Cell Properties but Exhibit Characteristics of Aging and Have Impaired Angiogenic Potential

(2013) Anastasia Efimenko et al.   Stem Cells Translational Medicine

Osteogenic and angiogenic potentials of monocultured and co-cultured human-bone-marrow-derived mesenchymal stem cells and human-umbilical-vein endothelial cells on three-dimensional porous beta-tricalcium phosphate scaffold

(2012) Yunqing Kang et al.   Acta Biomaterialia

Engineering Vascularized Bone Graft With Osteogenic and Angiogenic Lineage Differentiated Bone Marrow Mesenchymal Stem Cells

(2012) Rong Zhang et al.   ARTIFICIAL ORGANS

Angiogenic and osteogenic potential of platelet-rich plasma and adipose-derived stem cell laden alginate microspheres

(2012) Yi Man et al.   BIOMATERIALS

Review: Development of clinically relevant scaffolds for vascularised bone tissue engineering

(2012) Yuchun Liu et al.   BIOTECHNOLOGY ADVANCES

Emerging Ideas: Engineering the Periosteum: Revitalizing Allografts by Mimicking Autograft Healing

(2012) Michael D. Hoffman et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Advances in the formation, use and understanding of multi-cellular spheroids

(2012) Toni-Marie Achilli et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Endothelial differentiation of mesenchymal stromal cells: when traditional biology meets mechanotransduction

(2012) Orazio Vittorio et al.   Integrative Biology

In situ formation of porous space maintainers in a composite tissue defect

(2012) Patrick P. Spicer et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Engineered bone tissue associated with vascularization utilizing a rotating wall vessel bioreactor

(2012) Masanori Nishi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Evaluation of bone regeneration, angiogenesis, and hydroxyapatite conversion in critical-sized rat calvarial defects implanted with bioactive glass scaffolds

(2012) Lianxiang Bi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Differential analysis of peripheral blood- and bone marrow-derived endothelial progenitor cells for enhanced vascularization in bone tissue engineering

(2012) Ami R. Amini et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Guided Bone Regeneration Using Injectable Vascular Endothelial Growth Factor Delivery Gel

(2012) Darnell Kaigler et al.   JOURNAL OF PERIODONTOLOGY

Engineering axially vascularized bone in the sheep arteriovenous-loop model

(2012) Anja M. Boos et al.   Journal of Tissue Engineering and Regenerative Medicine

Review of vascularised bone tissue-engineering strategies with a focus on co-culture systems

(2012) Yuchun Liu et al.   Journal of Tissue Engineering and Regenerative Medicine

Perivascular-Like Cells Contribute to the Stability of the Vascular Network of Osteogenic Tissue Formed from Cell Sheet-Based Constructs

(2012) Luís F. Mendes et al.   PLoS One

Engineering bone tissue from human embryonic stem cells

(2012) D. Marolt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Juxtacrine and Paracrine Interactions of Rat Marrow-Derived Mesenchymal Stem Cells, Muscle-Derived Satellite Cells, and Neonatal Cardiomyocytes with Endothelial Cells in Angiogenesis Dynamics

(2012) Reza Rahbarghazi et al.   STEM CELLS AND DEVELOPMENT

Effect of Adipose Tissue-Derived Osteogenic and Endothelial Cells on Bone Allograft Osteogenesis and Vascularization in Critical-Sized Calvarial Defects

(2012) Agustin Cornejo et al.   TISSUE ENGINEERING PART A

A Differential Effect of Bone Morphogenetic Protein-2 and Vascular Endothelial Growth Factor Release Timing on Osteogenesis at Ectopic and Orthotopic Sites in a Large-Animal Model

(2012) Ruth E. Geuze et al.   TISSUE ENGINEERING PART A

Sequential Application of Steady and Pulsatile Medium Perfusion Enhanced the Formation of Engineered Bone

(2012) Cristina Correia et al.   TISSUE ENGINEERING PART A

A Platelet-Rich Plasma-Based Membrane as a Periosteal Substitute with Enhanced Osteogenic and Angiogenic Properties: A New Concept for Bone Repair

(2012) Rania M. El Backly et al.   TISSUE ENGINEERING PART A

Vascularized Bone Tissue Engineering: Approaches for Potential Improvement

(2012) Lonnissa H. Nguyen et al.   TISSUE ENGINEERING PART B-REVIEWS

Bioactive Glass Foam Scaffolds are Remodelled by Osteoclasts and Support the Formation of Mineralized Matrix and Vascular Networks In Vitro

(2012) Swati Midha et al.   Advanced Healthcare Materials

Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering

(2011) Chengtie Wu et al.   BIOMATERIALS

Blood vessel formation in the tissue-engineered bone with the constitutively active form of HIF-1α mediated BMSCs

(2011) Duohong Zou et al.   BIOMATERIALS

Angiogenesis in bone regeneration

(2011) Kurt D. Hankenson et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Vascularization of prevascularized and non-prevascularized fibrin-based human adipose tissue constructs after implantation in nude mice

(2011) Femke Verseijden et al.   Journal of Tissue Engineering and Regenerative Medicine

In Vitro Model of Vascularized Bone: Synergizing Vascular Development and Osteogenesis

(2011) Cristina Correia et al.   PLoS One

Concise Review: Induced Pluripotent Stem Cells and Lineage Reprogramming: Prospects for Bone Regeneration

(2011) Damir J. Illich et al.   STEM CELLS

Cell Sources for Bone Tissue Engineering: Insights from Basic Science

(2011) Céline Colnot   TISSUE ENGINEERING PART B-REVIEWS

Evaluation of Angiogenesis and Osteogenesis

(2011) Anusuya Das et al.   TISSUE ENGINEERING PART B-REVIEWS

Bone Tissue Engineering Bioreactors: A Role in the Clinic?

(2011) Erin Salter et al.   TISSUE ENGINEERING PART B-REVIEWS

Angiopoiesis and bone regeneration via co-expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivo

(2010) Chen Zhang et al.   ACTA PHARMACOLOGICA SINICA

Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized β-tricalcium phosphate scaffold and mesenchymal stem cells

(2010) Le Wang et al.   BIOMATERIALS

Hyaluronic acid hydrogels with controlled degradation properties for oriented bone regeneration

(2010) Jennifer Patterson et al.   BIOMATERIALS

An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects

(2010) Yash M. Kolambkar et al.   BIOMATERIALS

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

(2010) Christa Maes et al.   DEVELOPMENTAL CELL

Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms

(2010) Cyrus M. Ghajar et al.   EXPERIMENTAL CELL RESEARCH

Silicate, borosilicate, and borate bioactive glass scaffolds with controllable degradation rate for bone tissue engineering applications. II. In vitro and in vivo biological evaluation

(2010) Qiang Fu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Growth factor delivery-based tissue engineering: general approaches and a review of recent developments

(2010) K. Lee et al.   Journal of the Royal Society Interface

Collagen glycation alters neovascularization in vitro and in vivo

(2010) Megan E. Francis-Sedlak et al.   MICROVASCULAR RESEARCH

Clinical Flap Prefabrication

(2010) Lifei Guo et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Bone Formation and Neovascularization Mediated by Mesenchymal Stem Cells and Endothelial Cells in Critical-Sized Calvarial Defects

(2010) Sebastian Koob et al.   TISSUE ENGINEERING PART A

Tubular Perfusion System for the Long-Term Dynamic Culture of Human Mesenchymal Stem Cells

(2010) Andrew B. Yeatts et al.   TISSUE ENGINEERING PART C-METHODS

A COMPREHENSIVE REVIEW OF THE SAFETY PROFILE OF BONE MORPHOGENETIC PROTEIN IN SPINE SURGERY

(2010) David Benglis et al.   Operative Neurosurgery

Crosstalk between osteoblasts and endothelial cells co-cultured on a polycaprolactone–starch scaffold and the in vitro development of vascularization

(2009) Marina I. Santos et al.   BIOMATERIALS

The use of platelet-rich plasma in bone reconstruction therapy

(2009) Giuseppe Intini   BIOMATERIALS

Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model

(2009) Justus P. Beier et al.   Journal of Tissue Engineering and Regenerative Medicine

Vascularization in Bone Tissue Engineering: Physiology, Current Strategies, Major Hurdles and Future Challenges

(2009) Marina I. Santos et al.   MACROMOLECULAR BIOSCIENCE

Periosteum-Guided Prefabrication of Vascularized Bone of Clinical Shape and Volume

(2009) Ming-Huei Cheng et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Dose Effect of Dual Delivery of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein-2 on Bone Regeneration in a Rat Critical-Size Defect Model

(2009) Simon Young et al.   TISSUE ENGINEERING PART A

Effect of Bioactive Glasses on Angiogenesis: A Review of In Vitro and In Vivo Evidences

(2009) Alejandro A. Gorustovich et al.   TISSUE ENGINEERING PART B-REVIEWS

The effect of mesenchymal populations and vascular endothelial growth factor delivered from biodegradable polymer scaffolds on bone formation

(2008) Janos M. Kanczler et al.   BIOMATERIALS

Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model

(2008) Zarana S. Patel et al.   BONE

In vivo engineering of a human vasculature for bone tissue engineering applications

(2008) Lilian Steffens et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2

(2008) Verónica Alonso et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Prevascularization of a Fibrin-Based Tissue Construct Accelerates the Formation of Functional Anastomosis with Host Vasculature

(2008) Xiaofang Chen et al.   TISSUE ENGINEERING PART A

Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies

(2007) A. Stolzing et al.   MECHANISMS OF AGEING AND DEVELOPMENT