Vascularization Strategies for Bone Regeneration

The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen–glycosaminoglycan scaffold in vivo

(2013) T.M. McFadden et al.   Acta Biomaterialia

Recovery from hind limb ischemia enhances rhBMP-2-mediated segmental bone defect repair in a rat composite injury model

(2013) Brent A. Uhrig et al.   BONE

Soft-Tissue Reconstruction of Open Fractures of the Lower Limb

(2013) James K.-K. Chan et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis

(2012) Hidenori Matsubara et al.   BONE

Role of shear-stress-induced VEGF expression in endothelial cell survival

(2012) Nathaniel G. dela Paz et al.   JOURNAL OF CELL SCIENCE

Stimulation of neo-angiogenesis by combined use of irradiated and vascularized living bone graft for oncological reconstruction

(2012) Keiichi Muramatsu et al.   SURGICAL ONCOLOGY-OXFORD

Oxygenated Environment Enhances Both Stem Cell Survival and Osteogenic Differentiation

(2012) Shimon Benjamin et al.   TISSUE ENGINEERING PART A

Attenuated Human Bone Morphogenetic Protein-2–Mediated Bone Regeneration in a Rat Model of Composite Bone and Muscle Injury

(2012) Nick J. Willett et al.   TISSUE ENGINEERING PART C-METHODS

Vascularization is the key challenge in tissue engineering

(2011) Esther C. Novosel et al.   ADVANCED DRUG DELIVERY REVIEWS

Stem Cell Engraftment and Survival in the Ischemic Heart

(2011) Kai Hong Wu et al.   ANNALS OF THORACIC SURGERY

Stromal Vascular Fraction From Adipose Tissue Forms Profound Vascular Network Through the Dynamic Reassembly of Blood Endothelial Cells

(2011) Young Jun Koh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Determinants of Microvascular Network Topologies in Implanted Neovasculatures

(2011) Carlos C. Chang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of protein dose and delivery system on BMP-mediated bone regeneration

(2011) Joel D. Boerckel et al.   BIOMATERIALS

Myogenic progenitors contribute to open but not closed fracture repair

(2011) Renjing Liu et al.   BMC MUSCULOSKELETAL DISORDERS

Angiogenesis in bone regeneration

(2011) Kurt D. Hankenson et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Allograft bone matrix versus synthetic bone graft substitutes

(2011) Gerald Zimmermann et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Effects of in vivo mechanical loading on large bone defect regeneration

(2011) Joel D. Boerckel et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mechanical regulation of vascular growth and tissue regeneration in vivo

(2011) J. D. Boerckel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized β-tricalcium phosphate scaffold and mesenchymal stem cells

(2010) Le Wang et al.   BIOMATERIALS

Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma

(2010) Philipp Niemeyer et al.   BIOMATERIALS

The Role of Endothelial Progenitor Cells in Prevascularized Bone Tissue Engineering: Development of Heterogeneous Constructs

(2010) Natalja E. Fedorovich et al.   TISSUE ENGINEERING PART A

Short-Term Cultivation of In Situ Prevascularized Tissue Constructs Accelerates Inosculation of Their Preformed Microvascular Networks After Implantation into the Host Tissue

(2010) Matthias W. Laschke et al.   TISSUE ENGINEERING PART A

Surgical angiogenesis: a new approach to maintain osseous viability in xenotransplantation

(2010) Yang-Guk Chung et al.   XENOTRANSPLANTATION

Hemodynamic Forces, Vascular Oxidative Stress, and Regulation of BMP-2/4 Expression

(2009) Anna Csiszar et al.   ANTIOXIDANTS & REDOX SIGNALING

The use of a synthetic oxygen carrier-enriched hydrogel to enhance mesenchymal stem cell-based bone formation in vivo

(2009) Nadav Kimelman-Bleich et al.   BIOMATERIALS

Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1a

(2009) Renjing Liu et al.   BMC MUSCULOSKELETAL DISORDERS

Improving lower limb salvage following fractures with vascular injury: a systematic review and new management algorithm

(2009) G.E. Glass et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model

(2009) Justus P. Beier et al.   Journal of Tissue Engineering and Regenerative Medicine

Implanted microvessels progress through distinct neovascularization phenotypes

(2009) Sara S. Nunes et al.   MICROVASCULAR RESEARCH

Inspiration and application in the evolution of biomaterials

(2009) Nathaniel Huebsch et al.   NATURE

Cell-free and cell-based approaches for bone regeneration

(2009) Ericka M. Bueno et al.   Nature Reviews Rheumatology

Prevascularization of cardiac patch on the omentum improves its therapeutic outcome

(2009) T. Dvir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Short-Time Survival and Engraftment of Bone Marrow Stromal Cells in an Ectopic Model of Bone Regeneration

(2009) Paolo Giannoni et al.   TISSUE ENGINEERING PART A

Vascularization—The Conduit to Viable Engineered Tissues

(2009) Tamar Kaully et al.   TISSUE ENGINEERING PART B-REVIEWS

Vascular endothelial growth factor regulates osteoblast survival – evidence for an autocrine feedback mechanism

(2009) John Street et al.   Journal of Orthopaedic Surgery and Research

Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model

(2008) Zarana S. Patel et al.   BONE

Effect of mechanical boundary conditions on orientation of angiogenic microvessels

(2008) L. Krishnan et al.   CARDIOVASCULAR RESEARCH

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Hypoxia in Static and Dynamic 3D Culture Systems for Tissue Engineering of Bone

(2008) Elias Volkmer et al.   TISSUE ENGINEERING PART A

Prevascularization of a Fibrin-Based Tissue Construct Accelerates the Formation of Functional Anastomosis with Host Vasculature

(2008) Xiaofang Chen et al.   TISSUE ENGINEERING PART A

Accelerated fracture healing in the geriatric, osteoporotic rat with recombinant human platelet-derived growth factor-bb and an injectable beta-tricalcium phosphate/collagen matrix

(2007) Jeffrey O. Hollinger et al.   JOURNAL OF ORTHOPAEDIC RESEARCH