Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain

Sub-diffraction imaging on standard microscopes through photobleaching microscopy with non-linear processing

(2012) S. Munck et al.   JOURNAL OF CELL SCIENCE

Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors

(2011) Danielle L. Aubele et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Excitotoxicity-induced endocytosis mediates neuroprotection by TAT-peptide-linked JNK inhibitor

(2011) Anne Vaslin et al.   JOURNAL OF NEUROCHEMISTRY

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-Related Progressive Synaptic Dysfunction: The Critical Role of Presenilin 1

(2011) Alexandra Auffret et al.   REVIEWS IN THE NEUROSCIENCES

NerveCenter: New evidence of preserved cognition in unresponsive TBI patient raises questions, concerns

(2010) Kurt Samson   ANNALS OF NEUROLOGY

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

The Amyloid Precursor Protein C-Terminal Fragment C100 Occurs in Monomeric and Dimeric Stable Conformations and Binds γ-Secretase Modulators

(2010) Anne Botev et al.   BIOCHEMISTRY

Alzheimer's Disease Neurons Fail the Acid Test

(2010) Wim Annaert et al.   CELL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

REVIEW: γ-Secretase Inhibitors for the Treatment of Alzheimer's Disease: The Current State

(2010) Francesco Panza et al.   CNS Neuroscience & Therapeutics

TAT-mediated delivery of neuroglobin protects against focal cerebral ischemia in mice

(2010) Bin Cai et al.   EXPERIMENTAL NEUROLOGY

Notch Signaling in the Immune System

(2010) Freddy Radtke et al.   IMMUNITY

γ-secretases: from cell biology to therapeutic strategies

(2010) Bruno A Bergmans et al.   LANCET NEUROLOGY

Alzheimer's failure raises questions about disease-modifying strategies

(2010) Andy Extance   NATURE REVIEWS DRUG DISCOVERY

Her4 and Her2/neu Tyrosine Kinase Domains Dimerize and Activate in a Reconstitutedin VitroSystem

(2009) John Monsey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAT-conjugated nanoparticles for the CNS delivery of anti-HIV drugs

(2008) Kavitha S. Rao et al.   BIOMATERIALS

Interaction between Reelin and Notch Signaling Regulates Neuronal Migration in the Cerebral Cortex

(2008) Kazue Hashimoto-Torii et al.   NEURON

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

(2003) H. F. Dovey et al.   JOURNAL OF NEUROCHEMISTRY