Article
Gastroenterology & Hepatology
Timothy Donnison, Joey McGregor, Senthil Chinnakannan, Claire Hutchings, Rob J. Center, Pantelis Poumbourios, Paul Klenerman, Heidi E. Drummer, Eleanor Barnes
Summary: This study aims to develop a vaccine that can generate both viral-specific B-cell and T-cell responses concurrently to target multiple HCV genotypes.
Review
Biotechnology & Applied Microbiology
Alison Schaefer, Samuel K. Lai
Summary: IgG antibodies have an under-recognized effector function of trapping pathogens in mucus at mucosal surfaces, preventing them from contacting target cells and facilitating rapid elimination. This function, revealed in the past decade, is a universal effector of IgG-Fc capable of immobilizing various types of pathogens.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Rasheid Smith, Emad Wafa, Sean M. Geary, Kareem Ebeid, Suhaila O. Alhaj-Suliman, Aliasger K. Salem
Summary: Nanoscale formulations can enhance the efficacy of cancer vaccines by combating the immunosuppressive nature of the tumor microenvironment. A newly synthesized nanoparticulate formulation demonstrated adjuvant properties in vivo, leading to increased TAA-specific T cells, reduced tumor burden, protection against tumor rechallenge, and improved median survival in tumor-challenged mice.
Review
Virology
Yixuan Wang, Wenwei Shao
Summary: Viral vectors play a crucial role in gene therapy, but the innate immune response remains a significant barrier to their clinical development. This review provides insights into the mechanisms of innate immune response induced by three widely used viral vectors and strategies to overcome innate immunity.
Article
Biology
Romain Darrigrand, Alison Pierson, Marine Rouillon, Dolor Renko, Mathilde Boulpicante, David Bouyssie, Emmanuelle Mouton-Barbosa, Julien Marcoux, Camille Garcia, Michael Ghosh, Mouad Alami, Sebastien Apcher
Summary: The study demonstrated that the spliceosome inhibitor IP2 can enhance antigen presentation, activate CD8(+) T cell response, and inhibit tumor growth by modifying the antigen repertoire displayed on MHC-I molecules in cancer cells. Combination of IP2 with a peptide vaccine targeting a specific epitope showed a synergistic antitumor effect.
COMMUNICATIONS BIOLOGY
(2021)
Article
Immunology
Vidthiya Jeyananthan, Sam Afkhami, Michael R. D'Agostino, Anna Zganiacz, Xueya Feng, Matthew S. Miller, Mangalakumari Jeyanathan, Michael R. Thompson, Zhou Xing
Summary: Infectious diseases of the respiratory tract are a major cause of global morbidity and mortality. Delivering vaccines through the respiratory mucosal route shows promise in combating respiratory infections. Through a study using mice, we found that compared to intranasal delivery, endotracheal delivery resulted in a deeper and wider distribution of the vaccine in the lungs, leading to improved immunogenicity and protection against the target pathogen. Our findings support the further development of inhaled aerosol delivery of vaccines over intranasal delivery for human use.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Leoni Rolfes, Steffen Pfeuffer, Jelena Skuljec, Xia He, Chuanxin Su, Sinem-Hilal Oezalp, Marc Pawlitzki, Tobias Ruck, Melanie Korsen, Konstanze Kleinschnitz, Derya Aslan, Tim Hagenacker, Christoph Kleinschnitz, Sven G. Meuth, Refik Pul
Summary: Cladribine-treated MS patients can mount an adequate immune response to influenza independently of treatment duration and time interval to the last cladribine administration. The antibody response against influenza A was comparable between cladribine-treated patients and controls, while the response against influenza B was lower in the cladribine cohort. The increase in geometric mean titers was also lower in the cladribine group compared to controls, but titers increased in both groups for all strains.
Article
Pharmacology & Pharmacy
C. Reboredo, C. J. Gonzalez-Navarro, C. Martinez-Oharriz, A. L. Martinez-Lopez, J. M. Irache
Summary: The study aimed to produce PEG-coated nanoparticles with mucus-permeating properties for oral drug delivery using simple procedures and regulatory-approved compounds. The nanoparticles were successfully coated with PEG 35,000, reducing their hydrophobic surface and increasing their hydrophilicity. This coating allowed the nanoparticles to have increased mobility in mucus, potentially enhancing the oral bioavailability of biomacromolecules and other biologically active compounds.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Immunology
Victor Araujo Correa, Amanda Izeli Portilho, Elizabeth De Gaspari
Summary: Vaccines are crucial in controlling infectious diseases, but most vaccines are not effective in providing mucosal protection. More research is needed to develop vaccines that can elicit mucosal immunity and provide protection at the first site of contact with pathogens.
Article
Pharmacology & Pharmacy
Myriam Lamrayah, Capucine Phelip, Celine Coiffier, Celine Lacroix, Thibaut Willemin, Thomas Trimaille, Bernard Verrier
Summary: This study investigates the potential of micelles composed of polylactide-block-poly(N-acryloxysuccinimide-co-N-vinylpyrrolidone) as a delivery system for vaccines. The micelles were non-toxic and efficiently taken up by immune cells. Coupling of antigenic protein p24 on the micelles improved its antigenicity. In mouse immunization, the micelles showed comparable immune response intensity to gold standards and higher avidity index over time.
Review
Biochemistry & Molecular Biology
L. Moine, M. M. Canali, C. Porporatto, S. G. Correa
Summary: Chitosan is a versatile polymer with various biomedical applications, and its chemical modification can give rise to numerous derivatives that are suitable for different types of drug formulations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell Biology
Phillip A. Swanson, Marcelino Padilla, Wesley Hoyland, Kelly McGlinchey, Paul A. Fields, Sagida Bibi, Saul N. Faust, Adrian B. McDermott, Teresa Lambe, Andrew J. Pollard, Nicholas M. Durham, Elizabeth J. Kelly
Summary: AZD1222 vaccine induces effective T cell responses in adults of all age groups, mainly of T(H)1 type, covering the SARS-CoV-2 spike protein. Vaccination with AZD1222 promotes immune responses and demonstrates broad immunological protection coverage across age groups.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Fisheries
Seyed Hossein Hoseinifar, Mohammad Amin Jahazi, Roghieh Mohseni, Morteza Yousefi, Mahsan Bayani, Mohammad Mazandarani, Hien Van Doan, Ehab R. El-Haroun
Summary: The study investigated the effects of apple peel-derived pectin on growth, antioxidant enzyme activity, and immune parameters in common carp. Results showed improvements in growth and immune response parameters with dietary pectin inclusion, as well as increased antioxidant enzyme activity levels. Further testing revealed significant effects on antibacterial activity, suggesting favorable outcomes for growth and immune responses in fish fed APDP.
Review
Gastroenterology & Hepatology
Qing Zhao, Craig L. Maynard
Summary: This brief review discusses recent findings on the host-microbiota mutualism at the colonic mucosal border. It highlights the interaction between the immune system and mucus-associated bacteria, as well as the potential significance of this knowledge for understanding chronic intestinal inflammation.
Article
Chemistry, Multidisciplinary
Philippe Grenier, Valerie Chenard, Nicolas Bertrand
Summary: Polyethylene glycol (PEG) is commonly found in nanomedicines and pharmaceuticals, and recent studies have shown that anti-PEG antibodies are present in a significant portion of the human population. Understanding the mechanisms behind the immune response to PEG is crucial, as these antibodies can impact the efficacy of PEGylated therapeutics. This study investigates the immune response to polymeric nanoparticles administered through different routes, and the results suggest that the mechanisms involved vary depending on the administration route. Knowledge of these mechanisms can be utilised to design nanomedicines that engage the immune system in specific ways.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Yazhen Wang, Huilin Zhang, Wei Xiao, Yuwei Liu, Yang Zhou, Xueqin He, Xue Xia, Tao Gong, Ling Wang, Huile Gao
Summary: The formation of protein corona from cerebrospinal fluid can impact the targeting capability of nanoparticles, leading to the loss of active targeting specificity and alteration of their cellular uptake pathways.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Multidisciplinary Sciences
Caifeng Deng, Quan Zhang, Penghui He, Bin Zhou, Ke He, Xun Sun, Guanghua Lei, Tao Gong, Zhirong Zhang
Summary: The study successfully delivered celastrol using enzyme-responsive nanoparticles to induce apoptosis of OCs and macrophages in rheumatoid arthritis joints, reducing inflammation and showing therapeutic effects in a rat model.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Yingying Xu, Yining Niu, Beibei Wu, Xi Cao, Tao Gong, Zhi-Rong Zhang, Yao Fu
Summary: The study demonstrates a successful strategy involving the localized and sustained delivery of miR-29 b using a host-guest supramolecular hydrogel, proving effective in inhibiting renal interstitial fibrosis progression, with potential therapeutic applications.
Article
Chemistry, Physical
Shiqi Huang, Lang Deng, Hanming Zhang, Luyao Wang, Yicong Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: In this study, a novel nanoplatform was developed to deliver TRAIL and PTX to lung melanoma tumor sites, effectively killing tumor cells and reducing local nutrition supply. This system showed remarkable anti-tumor effects and significantly prolonged the survival rate of melanoma lung metastasis bearing mice.
Article
Chemistry, Multidisciplinary
Ming Qin, Guangsheng Du, Nan Qiao, Zhaofei Guo, Min Jiang, Chunting He, Shuting Bai, Penghui He, Yanhua Xu, Hairui Wang, Tao Gong, Zhirong Zhang, Xun Sun
Summary: A simple strategy has been developed to convert whole-cell vaccines into nanoscale size to promote their lymphatic migration and intracellular antigen presentation, aiming to enhance immune responses. The universal carrier-free nano-vaccine fabricated through a two-step vortex-sonification method based on alum-induced and cancer/bacterial cell membrane coated protein antigen nanoparticles can efficiently migrate to lymph nodes after subcutaneous vaccination, where they are taken up by APCs for antigen presentation and activation of immune processes.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Liqiang Chen, Chendong Liu, Yucheng Xiang, Jiayan Lyu, Zhou Zhou, Tao Gong, Huile Gao, Lian Li, Yuan Huang
Summary: A new strategy for targeting the endoplasmic reticulum (ER) is proposed in this study, which utilizes homologous cancer cell membrane-coated nanoparticles (HCC@NP) to overcome the limited accumulation and rapid exocytosis of nanodrugs in the ER. The strategy achieves high-efficiency and long-term ER retention, inducing potent immunogenic cell death and promoting anti-tumor immunity.
Article
Chemistry, Multidisciplinary
Yuan Xue, Shuting Bai, Leilei Wang, Shi Luo, Zhirong Zhang, Tao Gong, Ling Zhang
Summary: The study developed a multi-stimulus-responsive PS nanocarrier, significantly improving the efficacy of Ce6 in PDT, showing remarkable tumor-killing effects and increasing the survival rate of tumor-bearing mice.
Article
Chemistry, Multidisciplinary
Xiaofang Zhong, Guangsheng Du, Xuanyu Wang, Yangsen Ou, Hairui Wang, Yining Zhu, Xinyan Hao, Zhiqiang Xie, Yuandong Zhang, Tao Gong, Zhirong Zhang, Xun Sun
Summary: A proposed subcutis-to-intestine cascade using nanovaccines efficiently enhances cellular and mucosal immune responses. Experimental results demonstrate that nanovaccines can generate protective immunity against Salmonella challenge.
Article
Pharmacology & Pharmacy
Lei Wu, Lingling Wang, Xi Liu, Yuli Bai, Ruinan Wu, Xiang Li, Yutong Mao, Ling Zhang, Yongxiang Zheng, Tao Gong, Zhirong Zhang, Yuan Huang
Summary: Exosomes, as endogenous courier vesicles, have gained increasing attention as biomimetic drug delivery vehicles. In this study, insulin-loaded milk-derived exosomes were fabricated and demonstrated to exhibit superior hypoglycemic effects when orally administered, compared with subcutaneously injected insulin. Mechanism studies revealed the multi-functional properties of milk-derived exosomes, including active multi-targeting uptake, pH adaptation, signal pathway activation, and mucus penetration, which contribute to their excellent oral performance.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Nanoscience & Nanotechnology
Jiaxing Feng, Ling Xiang, Changlong Fang, Yulu Tan, Yan Li, Ting Gong, Qingsi Wu, Tao Gong, Zhirong Zhang
Summary: THP-PSA NPs exhibit stronger cytotoxicity against 4T1 and M2 macrophages compared with THP-HSA NPs in vitro. In vivo, MDSCs infiltration and immunosuppressive cytokines secretion significantly decrease after effective elimination of TAMs through THP-PSA NPs treatment, accompanied by an increase in immunostimulatory cytokine expression.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Ting Zhao, Rongping Zhang, Qin He, Hongli Zhou, Xu Song, Tao Gong, Zhirong Zhang
Summary: This study established a CAF-targeting drug delivery system based on RBC vesicles partial protection for reprogramming the tumor microenvironment and enhancing tumor penetration and antitumor efficacy in PDAC. The results showed that the system improved the penetration of Dox in PDAC and inhibited tumor growth.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Haohuan Li, Caifeng Deng, Yulu Tan, Jianxia Dong, Yuanhao Zhao, Xiaorong Wang, Xingyue Yang, Jingwen Luo, Huile Gao, Yuan Huang, Zhi-Rong Zhang, Tao Gong
Summary: This study presents a promising approach for photodynamic immunotherapy of advanced cancers by using chondroitin sulfate-based prodrug nanoparticles to co-deliver a photosensitizer and retinoic acid. This approach can reduce the immunosuppression caused by photodynamic therapy and promote the maturation of dendritic cells. The strategy showed excellent antitumor efficacy in a mouse model.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Physical
Xiaomin Xu, Yani Xu, Yuai Li, Min Li, Leilei Wang, Qiang Zhang, Bingjie Zhou, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: In this study, a glucose-responsive system mimicking erythrocytes was designed by coupling glucose-responsive nanoparticles to red blood cells, allowing for long-term response to hyperglycemia and potential application in diabetes treatment.
Article
Chemistry, Multidisciplinary
Zhaofei Guo, Yining Zhu, Guangsheng Du, Ming Qin, Chunting He, Penghui He, Yuanshuai Song, Wenfei Chen, Shuting Bai, Fuhua Wu, Nan Qiao, Min Jiang, Xianjin Luo, Yuandong Zhang, Tao Gong, Zhirong Zhang, Xun Sun
Summary: This study reports a facile strategy for the rapid development of a highly effective cross-protective Pseudomonas aeruginosa vaccine. By loading cytosolic antigens derived from bacterial lysates into mesoporous silica nanospheres and fusing membrane antigens onto the surface, the engineered nano-vaccines induced potent humoral and cellular immune responses and protected against different strains of Pseudomonas aeruginosa infection.
Article
Materials Science, Biomaterials
Min Li, Xiaomin Xu, Rongying Shi, Yuai Li, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: By using the erythrocyte-hitchhiking strategy, the blood circulation time of an insulin delivery system was significantly prolonged, allowing for long-term and automatic blood glucose control in diabetic patients. This approach shows great potential for future development due to its versatility and ability to interact with other substances.
BIOMATERIALS SCIENCE
(2022)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
