Review
Biochemistry & Molecular Biology
Xi Wang, Yiming Chen, Yongjuan Wang, Bangmao Wang, Jie Zhang, Xu Jian
Summary: PEPT1 plays a critical role in the absorption of peptides in the intestinal tract and its abnormal expression in malignant tumors is closely related to tumor progression. It can be considered as a potential molecular biomarker for malignant tumors and can be used for targeted delivery of anti-tumor drugs.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Bradley K. Schniers, Devaraja Rajasekaran, Ksenija Korac, Tyler Sniegowski, Vadivel Ganapathy, Yangzom D. Bhutia
Summary: PEPT1 and PEPT2, two proton-coupled peptide transporters, are up-regulated in PDAC cell lines and PDXs. Inhibiting PEPT1 can reduce cancer cell proliferation, highlighting its critical role in cancer cell survival. Tumor-derived lactic acid in the microenvironment supports PEPT1 function, indicating a potential therapeutic target for pancreatic cancer.
BIOCHEMICAL JOURNAL
(2021)
Article
Fisheries
Zhimin He, Yuyang Cai, Ming Yang, Na Liu, Zihao Zeng, Xiaojie Li, Xiaomei Zhou, Suchun Liu, Zhen Liu
Summary: This study extensively investigated the regulation mechanism of C.idellus PepT1 by CDX2. It was found that CDX2 interacted with SP1 and directly up-regulated the activity of PepT1. Repression of CDX2 resulted in a significant decrease in PepT1 mRNA expression, while increased stability of CDX2 protein led to elevated expression of PepT1. These findings provide new insights into the regulation mechanism of PepT1 by CDX2 in C.idellus and have implications for efficient transportation of intestinal oligopeptides in teleost fish.
AQUACULTURE REPORTS
(2022)
Article
Gastroenterology & Hepatology
Junsik Sung, Lixin Wang, Dingpei Long, Chunhua Yang, Didier Merlin
Summary: Genetic knockout of PepT1 protein provides resistance to acute colitis and colitis-associated cancer in mouse models. The altered fecal metabolites, particularly tuberonic acid (TA), in PepT1 KO mice play a crucial role in anti-inflammatory effects and epithelial cell healing processes. This study sheds light on the potential mechanisms associated with the protective effects of PepT1 KO.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Miaomiao Zhou, Guiqin Liu, Wenqiang Liu, Mingxia Zhu, Changfa Wang
Summary: This study characterized the molecular cloning, tissue distribution, and functional properties of donkey PepT2, showing higher expression in the kidney and lung compared to other organs. Functional analysis in Chinese hamster ovary cells revealed specific uptake characteristics of PepT2, providing new insights into its crucial role in oligopeptide transport in donkeys.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Chemistry, Medicinal
Qikun Jiang, Qiuchi Xu, Yingli Wang, Pengyan Li, Yunran Zhang, Yongjun Wang, Jin Sun, Tianhong Zhang, Zhonggui He
Summary: By modulating the chirality of the linear dipeptide HS-tLL, the colon-targeting efficiency can be enhanced, providing a potential treatment for inflammatory bowel disease (IBD).
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Yuanyuan Li, Min Yang, Yanli Zhao, Lingbing Li, Wei Xu
Summary: A series of novel amphiphilic paclitaxel prodrugs were designed, synthesized, and evaluated, showing improved aqueous solubility and potential for enhanced oral bioavailability mediated by the PEPT1 transporter. These prodrugs could self-assemble into nanoparticles, effectively improving paclitaxel solubility, stability, and anticancer activity. PTX-SS-Val demonstrated particularly promising results in enhancing oral bioavailability and anticancer effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jiasha Wu, Ruifang Li, Yunpeng Shen, Xinhui Zhang, Xueqin Wang, Zichao Wang, Yingyuan Zhao, Liang Huang, Lan Zhang, Beibei Zhang
Summary: This study investigated the relationship between CGA-N9 transmembrane amount and its lethality kinetics in Candida tropicalis cells, and found a positive correlation between the transmembrane amount and candicidal activity of CGA-N9. Twelve oligopeptide transporter (OPT) coding sequences were cloned from C. tropicalis, named CtOPT1, CtOPT9, and CtOPT12, which were shown to strongly interact with CGA-N9. Therefore, CtOPT1, CtOPT9, and CtOPT12 were predicted to assist in the transmembrane transport of CGA-N9.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Kei Higuchi, Misato Kunieda, Koki Sugiyama, Ryuto Tomabechi, Hisanao Kishimoto, Katsuhisa Inoue
Summary: SLC16A13, encoding MCT13, may function as a novel basolateral oligopeptide transporter in intestinal epithelial cells. This study found that MCT13 can regulate the transport activity of oligopeptides and peptidomimetics, potentially playing a role in their transmembrane transport across intestinal epithelial cells.
Article
Pharmacology & Pharmacy
Yenju Chu, Abigail Wong, Haojie Chen, Liuhang Ji, Chaolong Qin, Wanshan Feng, Michael J. Stocks, Pavel Gershkovich
Summary: A military helicopter crash in Vietnam resulted in 13 deaths and 3 injuries. The cause of the accident is under investigation.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Xinran Wang, Cai Zhang, Ning Han, Juyuan Luo, Shuofeng Zhang, Chunguo Wang, Zhanhong Jia, Shouying Du
Summary: This study investigated the use of triglyceride-mimetic prodrugs to promote intestinal lymphatic transport of scutellarin and increase oral bioavailability. The experiments demonstrated that the prodrugs effectively enhanced the transport of the drug in intestinal lymph, leading to a significant increase in oral bioavailability.
Article
Fisheries
Yuexing Zhang, Yawei Zhang, Tianhong Ke, Bo Shi, Liying Huang, Zhiyong Dong, Mingyu Guo, Changarawe Samwel Mugeni, Aiyi Zhu, Linghua Wang, Jianbin Xu, Trond Storebakken
Summary: Replacing dietary fishmeal with a combination of soy protein concentrate, corn gluten meal, and hydrolysate of forage-fish or Pacific krill can reduce the use of fishmeal in largemouth bass feed. The expressions of pept1 and taut in fish fed HWF were dose-dependent, with upregulation observed at 25% replacement and downregulation with further replacement.
AQUACULTURE REPORTS
(2022)
Article
Plant Sciences
Pamela Guerillot, Asaf Salamov, Clementine Louet, Emmanuelle Morin, Pascal Frey, Igor V. Grigoriev, Sebastien Duplessis
Summary: Nutrient acquisition in rust fungi is mediated by a few transporters expressed in haustorial infection structures. Comparative genomic analysis revealed a reduced transportome in rust fungi compared with other fungi in the Dikarya, although some transporter families, particularly those related to metal transport, showed significant expansions. The oligopeptide transporter (OPT) family exhibited the most remarkable gene expansion in the rust fungi, with a potential role in nitrogen and sulfur acquisition during biotrophic growth.
Article
Ecology
Yujia Jing, Chunlong Mu, Huisong Wang, Junhua Shen, Erwin G. Zoetendal, Weiyun Zhu
Summary: The distribution of microbes in the mammalian intestine is heterogeneous and specific taxa, such as Lactobacillus, dominate across different mammals. This study investigates the relationship between nutrient utilization and the dominance of Lactobacillus amylovorus in the small intestine of pigs. The results suggest that the increased ability to utilize peptide-bound amino acids contributes to the dominance of L. amylovorus. These findings provide insights into the interaction between microbes and gut nutrition, and have implications for dietary interventions to improve gut health, particularly in the small intestine.
Article
Biochemistry & Molecular Biology
Min Shi, Ru Song, Luo Gu
Summary: The oxidative state of the intestinal tracts of healthy animals was studied after short-term intake of half-fin anchovy hydrolysates (HAHp) and their thermal or Maillard reaction products (MRPs). The results showed that the MRPs of HAHp-H, HAHp-3%G MRPs, and HAHp-3%F MRPs administration decreased serum tumor necrosis factor-alpha concentration compared to the control group (CK). No histological damage was observed in the jejunum, ileum, and colonic tissues of all groups. The thermal products of HAHp might have a broad application prospect in improving antioxidant defense in vivo in healthy animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Konstantinos Voskarides, Charalambos Stefanou, Myrtani Pieri, Panayiota Demosthenous, Kyriakos Felekkis, Maria Arsali, Yiannis Athanasiou, Dimitris Xydakis, Kostas Stylianou, Eugenios Daphnis, Giorgos Goulielmos, Petros Loizou, Judith Savige, Martin Hoehne, Linus A. Voelker, Thomas Benzing, Patrick H. Maxwell, Daniel P. Gale, Mathias Gorski, Carsten Boeger, Barbara Kollerits, Florian Kronenberg, Bernhard Paulweber, Michalis Zavros, Alkis Pierides, Constantinos Deltas
Article
Chemistry, Medicinal
David W. Foley, Ravindra B. Pathak, Theresa R. Phillips, Gayle L. Wilson, Patrick D. Bailey, Myrtani Pieri, Anish Senan, David Meredith
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Mathematical & Computational Biology
Kamil Erguler, Myrtani Pieri, Constantinos Deltas
BMC SYSTEMS BIOLOGY
(2013)
Article
Urology & Nephrology
Myrtani Pieri, Charalambos Stefanou, Apostolos Zaravinos, Kamil Erguler, Kostas Stylianou, George Lapathitis, Christos Karaiskos, Isavella Savva, Revekka Paraskeva, Harsh Dweep, Carsten Sticht, Natassa Anastasiadou, Ioanna Zouvani, Demetris Goumenos, Kyriakos Felekkis, Moin Saleem, Konstantinos Voskarides, Norbert Gretz, Constantinos Deltas
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2014)
Article
Multidisciplinary Sciences
Louiza Papazachariou, Panayiota Demosthenous, Myrtani Pieri, Gregory Papagregoriou, Isavella Savva, Christoforos Stavrou, Michael Zavros, Yiannis Athanasiou, Kyriakos Ioannou, Charalambos Patsias, Alexia Panagides, Costas Potamitis, Kyproula Demetriou, Marios Prikis, Michael Hadjigavriel, Maria Kkolou, Panayiota Loukaidou, Androulla Pastelli, Aristos Michael, Akis Lazarou, Maria Arsali, Loukas Damianou, Ioanna Goutziamani, Andreas Soloukides, Lakis Yioukas, Avraam Elia, Ioanna Zouvani, Polycarpos Polycarpou, Alkis Pierides, Konstantinos Voskarides, Constantinos Deltas
Letter
Urology & Nephrology
Myrtani Pieri
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Biochemistry & Molecular Biology
Kyriacos Felekkis, Myrtani Pieri, Christos Papaneophytou
Summary: Exosomes are small membrane vesicles containing specific RNA transcripts that facilitate cell-to-cell communication. Exosomal miRNAs in blood circulation are considered potential biomarkers for various diseases, but difficulties in clinical use exist due to high variability among individuals.
Article
Medicine, General & Internal
Marios Argyrou, Myrtani Pieri, Lefkios Paikoussis, Skevi Kyriakou, Philippos C. Patsalis, Kyriacos Felekkis, Marios Hadjicharalambous
Summary: The NOS3-786 TT genotype is positively correlated with better performance in speed and jumps in boys, consistent with previous literature linking this genotype to power elite athletes. The molecular mechanism underlying this advantage in power exercises is still being investigated.
GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
(2021)
Article
Biochemistry & Molecular Biology
Myrtani Pieri, Elena Theori, Harsh Dweep, Myrofora Flourentzou, Foteini Kalampalika, Maria-Arsenia Maniori, Gregory Papagregoriou, Christos Papaneophytou, Kyriacos Felekkis
Summary: Colorectal cancer is the third most frequent human cancer globally. High consumption of red meat, including beef, is considered a risk factor for its initiation and progression. This study discovered that exogenous bovine miRNAs ingested into the body may have an effect on human cells. The research found that bovine miRNA can still be detected after cooking and digestion, but it does not affect the viability of human cell lines. Further experiments will explore whether bovine miRNA can contribute to the progression of colorectal cancer through its consumption.
Article
Nutrition & Dietetics
Myrtani Pieri, Maria-Arsenia Maniori, Lucy Shahabian, Elie Kanaan, Irene Paphiti-Demetriou, Spyros Pipis, Kyriakos Felekkis, Vicky Nicolaidou, Christos Papaneophytou
Summary: Research shows that antibodies in breastmilk after vaccination can resist infant digestion to some extent, especially IgA antibodies. These results provide important information for understanding the role of breastfeeding during the COVID-19 pandemic.
Review
Biochemistry & Molecular Biology
Vicky Nicolaidou, Rafaela Georgiou, Maria Christofidou, Kyriacos Felekkis, Myrtani Pieri, Christos Papaneophytou
Summary: SARS-CoV-2 is the virus causing COVID-19, and several vaccines have been approved for emergency use. Data on the effects of the vaccines on breast milk are lacking, but studies have shown the presence of antibodies in breast milk after vaccination or natural infection. This study aims to summarize the current understanding of immunoglobulins in breast milk elicited by COVID-19 vaccines and evaluate their virus-neutralizing ability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Myrtani Pieri, Panayiotis Vayianos, Vicky Nicolaidou, Kyriacos Felekkis, Christos Papaneophytou
Summary: This critical review explores the relationship between COVID-19 and CVD, focusing on cardio-specific miRNAs and their association with various CVDs. Limited research suggests that changes in expression levels of COVID-19-related miRNAs may be linked to CVDs. Further research on the relationship between SARS-CoV-2, CVDs, and miRNAs will enhance our understanding and may lead to the use of these miRNAs as biomarkers or therapeutic targets for both pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Nutrition & Dietetics
Myrtani Pieri, Vicky Nicolaidou, Christos Papaneophytou
Article
Psychology, Multidisciplinary
Nikos Konstantinou, Stella A. Nicolaou, Christos Petrou, Myrtani Pieri
Summary: The study adapted a vaccine acceptance scale to the Greek language and examined the relationship between vaccine acceptance and beliefs, personal and family vaccination history, and demographic variables. The findings suggest that younger and less-educated individuals are more vaccine-hesitant, and that trust in authorities influences vaccine acceptance. These results have implications for understanding vaccine hesitancy and shaping public health policies related to vaccinations.
EUROPEAN JOURNAL OF PSYCHOLOGY OPEN
(2021)
Article
Urology & Nephrology
Charalambos Stefanou, Myrtani Pieri, Lsavella Savva, Georgia Georgiou, Alkis Pierides, Konstantinos Voskarides, Constantinos Deltas
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
