Jekyll and Hyde: the role of the microenvironment on the progression of cancer

Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma

(2010) P. G. Richardson et al.   BLOOD

The addition of cyclophosphamide to lenalidomide and dexamethasone in multiply relapsed/refractory myeloma patients; a phase I/II study

(2010) Stephen A. Schey et al.   BRITISH JOURNAL OF HAEMATOLOGY

A phase 2 pilot trial of low-dose, continuous infusion, or “metronomic” paclitaxel and oral celecoxib in patients with metastatic melanoma

(2010) Rupal S. Bhatt et al.   CANCER

Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival

(2010) Hui-Ping Hsu et al.   CANCER BIOLOGY & THERAPY

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Phase II Trial of Gemcitabine, Irinotecan, and Celecoxib in Patients With Advanced Pancreatic Cancer

(2010) Allan Lipton et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial

(2010) Francis KL Chan et al.   LANCET

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1α, GLUT1, and CAIX

(2010) Chi-Long Chen et al.   VIRCHOWS ARCHIV

A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX®) and interferon-alpha-2a in metastatic renal cell carcinoma patients

(2010) M. Siebels et al.   WORLD JOURNAL OF UROLOGY

Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients

(2009) S. Sauer et al.   BLOOD

APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profiling

(2009) Russell D Petty et al.   BMC CANCER

Five-Year Efficacy and Safety Analysis of the Adenoma Prevention with Celecoxib Trial

(2009) M. M. Bertagnolli et al.   Cancer Prevention Research

Direct Evidence that Bevacizumab, an Anti-VEGF Antibody, Up-regulates SDF1 , CXCR4, CXCL6, and Neuropilin 1 in Tumors from Patients with Rectal Cancer

(2009) L. Xu et al.   CANCER RESEARCH

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Role of hypoxia in the hallmarks of human cancer

(2009) Kai Ruan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mechanism of action of lenalidomide in hematological malignancies

(2009) Venumadhav Kotla et al.   Journal of Hematology & Oncology

Gene Expression Analysis of Macrophages That Facilitate Tumor Invasion Supports a Role for Wnt-Signaling in Mediating Their Activity in Primary Mammary Tumors

(2009) L. S. Ojalvo et al.   JOURNAL OF IMMUNOLOGY

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

(2009) G. Solinas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors

(2009) Andrew R Reynolds et al.   NATURE MEDICINE

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer

(2009) Pierre Farmer et al.   NATURE MEDICINE

A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth

(2009) Binzhi Qian et al.   PLoS One

Early response to COX-2 inhibitors as a predictor of overall response in osteoarthritis: pooled results from two identical trials comparing etoricoxib, celecoxib and placebo

(2009) C. O. Bingham et al.   RHEUMATOLOGY

The angiogenic switch in carcinogenesis

(2009) Vanessa Baeriswyl et al.   SEMINARS IN CANCER BIOLOGY

Targeting Vascular Endothelial Growth Factor in Renal Cell Carcinoma

(2009) Nilay S. Patel et al.   TUMOR BIOLOGY

A clinical study assessing the tolerability and biological effects of infliximab, a TNF-α inhibitor, in patients with advanced cancer

(2008) E. R. Brown et al.   ANNALS OF ONCOLOGY

Matrix Metalloproteinase-8 Functions as a Metastasis Suppressor through Modulation of Tumor Cell Adhesion and Invasion

(2008) A. Gutierrez-Fernandez et al.   CANCER RESEARCH

Bryostatin-5 Blocks Stromal Cell–Derived Factor-1 Induced Chemotaxis via Desensitization and Down-regulation of Cell Surface CXCR4 Receptors

(2008) Xing He et al.   CANCER RESEARCH

Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis

(2008) Sebastián Giulianelli et al.   INTERNATIONAL JOURNAL OF CANCER

Radiosensitization of Human Vascular Endothelial Cells Through Hsp90 Inhibition With 17-N-Allilamino-17-Demethoxygeldanamycin

(2008) Alexander E. Kabakov et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New insights into form and function of fibronectin splice variants

(2008) ES White et al.   JOURNAL OF PATHOLOGY

KINK-1, a Novel Small-Molecule Inhibitor of IKKβ, and the Susceptibility of Melanoma Cells to Antitumoral Treatment

(2008) Margarete Schön et al.   JNCI-Journal of the National Cancer Institute

Tumour immunity: effector response to tumour and role of the microenvironment

(2008) Alberto Mantovani et al.   LANCET

Macro-environment of breast carcinoma: frequent genetic alterations in the normal appearing skins of patients with breast cancer

(2008) Farid Moinfar et al.   MODERN PATHOLOGY

Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition

(2008) Hendrik Fischer et al.   MOLECULAR CANCER THERAPEUTICS

No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas

(2008) Wen Qiu et al.   NATURE GENETICS

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

Breast-Cancer Stromal Cells withTP53Mutations

(2008)   NEW ENGLAND JOURNAL OF MEDICINE