Review
Medicine, General & Internal
Xiaoying Zheng, Zejuan Fu, Xiaomei Chen, Mingxia Wang, Rixia Zhu
Summary: This study conducted a meta-analysis on the effects of ABCB1 gene polymorphism on antidepressant response, and the results will be published in a peer-reviewed journal.
Review
Nutrition & Dietetics
Hugo G. Winter, Daniel L. Rolnik, Ben W. J. Mol, Sophia Torkel, Simon Alesi, Aya Mousa, Nahal Habibi, Thais R. Silva, Tin Oi Cheung, Chau Thien Tay, Alejandra Quinteros, Jessica A. Grieger, Lisa J. Moran
Summary: This study examined the effect of different dietary patterns on fertility outcomes in both naturally conceiving populations and those requiring assisted reproductive technology (ART). The results showed conflicting findings, but suggested that adherence to the Mediterranean diet and various healthy diets could improve pregnancy and live birth rates.
Article
Biology
Giorgia Caspani, Gustavo Turecki, Raymond W. Lam, Roumen V. Milev, Benicio N. Frey, Glenda M. MacQueen, Daniel J. Muller, Susan Rotzinger, Sidney H. Kennedy, Jane A. Foster, Jonathan R. Swann
Summary: Caspani et al. demonstrate sex-specific plasma lipoproteins that can predict response to common antidepressants. They find that lipoproteins of the same class but different in size and density have unique associations with depression and treatment response, emphasizing the importance of evaluating lipoprotein subclasses in depression research.
COMMUNICATIONS BIOLOGY
(2021)
Review
Clinical Neurology
Helena K. Kim, Daniel M. Blumberger, Paul B. Fitzgerald, Benoit H. Mulsant, Zafiris J. Daskalakis
Summary: A systematic review and meta-analysis compared antidepressant outcomes in MDD patients with or without comorbidities, showing that those with physical or psychiatric comorbidities had worse outcomes. The high heterogeneity of the studies was a limitation. Overall, the evidence updated in this review indicates that MDD patients with comorbidities face challenges in achieving effective treatment outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Farhana Islam, Victoria S. Marshe, Leen Magarbeh, Benicio N. Frey, Roumen Milev, Claudio N. Soares, Sagar Parikh, Franca Placenza, Stephen C. Strother, Stefanie Hassel, Valerie H. Taylor, Francesco Leri, Pierre Blier, Rudolf Uher, Faranak Farzan, Raymond W. Lam, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Daniel J. Mueller
Summary: Cytochrome P450 drug-metabolizing enzymes, specifically CYP2C19 and CYP2D6 gene variants, have an impact on antidepressant outcomes. Poor metabolizers of CYP2C19 and CYP2D6 show less symptom improvement during treatment with escitalopram alone and are more likely to experience central nervous system side effects when taking escitalopram alone or in combination with aripiprazole.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neuroimaging
Pedro L. Ballester, Jee Su Suh, Nikita Nogovitsyn, Stefanie Hassel, Stephen C. Strother, Stephen R. Arnott, Luciano Minuzzi, Roberto B. Sassi, Raymond W. Lam, Roumen Milev, Daniel J. Muller, Valerie H. Taylor, Sidney H. Kennedy, Benicio N. Frey
Summary: The study found an elevated brain age gap in older individuals with major depressive disorder (MDD). Additionally, body mass index (BMI) was significantly associated with brain age gap in the MDD group. However, the brain age gap was not significantly associated with treatment response.
NEUROIMAGE-CLINICAL
(2021)
Review
Clinical Neurology
S. E. Cohen, J. B. Zantvoord, B. N. Wezenberg, J. G. Daams, C. L. H. Bockting, D. Denys, G. A. van Wingen
Summary: This study assessed the accuracy of electroencephalography (EEG) in predicting treatment response in major depressive disorder. The results showed that EEG can accurately predict the response to antidepressant treatment, but further validation studies are needed to develop a clinical tool for guiding interventions in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Amelia J. Scott, Louise Sharpe, Ben Colagiuri
Summary: The study found that there is little reporting on blinding in RCTs of antidepressants, with a high rate of blinding failure. Pharmaceutical company sponsorship predicted the assessment of blinding in trials, with unsponsored trials more likely to evaluate blinding.
PSYCHIATRY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Gustavo C. Medeiros, Todd D. Gould, William L. Prueitt, Julie Nanavati, Michael F. Grunebaum, Nuri B. Farber, Balwinder Singh, Sudhakar Selvaraj, Rodrigo Machado-Vieira, Eric D. Achtyes, Sagar V. Parikh, Mark A. Frye, Carlos A. Zarate, Fernando S. Goes
Summary: (R,S)-ketamine and (S)-ketamine have rapid and substantial antidepressant effects, but there is no well-accepted method to differentiate responders from non-responders. The association between blood-based biomarkers and response to ketamine was examined in a systematic review/meta-analysis, revealing limited evidence of a consistent relationship.
MOLECULAR PSYCHIATRY
(2022)
Review
Multidisciplinary Sciences
T. G. Bortoletto, T. Silva, A. Borovac-Pinheiro, C. M. Pereira, A. D. Silva, M. S. Franca, A. R. Hatanaka, J. P. Argenton, R. Passini, B. W. Mol, J. G. Cecatti, R. C. Pacagnella
Summary: This study aimed to assess the distribution of cervical length in women with singleton pregnancies and its association with population characteristics, highlighting the need for specific cervical length curves and cutoff values for different populations. Results showed varying cervical lengths in women from different regions, income levels, and body weights, emphasizing the importance of considering maternal population characteristics when evaluating cervical length as a risk factor for preterm birth.
Review
Orthopedics
Austin M. Looney, Julia A. McCann, Patrick T. Connelly, Spencer M. Comfort, Andrew J. Curley, William F. Postma
Summary: A systematic review and meta-analysis on the effects of routine capsular closure in hip arthroscopic surgery showed significantly higher postoperative scores and superior improvement with repair, while controlling for the effects of preoperative score and surgical indication. Large prospective randomized studies are needed to clarify the true magnitude of the benefit of capsular repair.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Review
Medicine, General & Internal
Gioia Brachini, Matteo Matteucci, Paolo Sapienza, Roberto Cirocchi, Alessandro Favilli, Stefano Avenia, Isaac Cheruiyot, Giovanni Tebala, Piergiorgio Fedeli, Justin Davies, Justus Randolph, Bruno Cirillo
Summary: Knowledge of vascular anatomy and its possible variations is crucial for performing pelvic surgeries. The obturator artery, a branch of the internal iliac artery, shows a high frequency of variation. A systematic review and meta-analysis of thirteen articles revealed that the majority of cases showed the origin of the obturator artery from the anterior division trunk of the internal iliac artery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Behavioral Sciences
Danilo Arnone, Omar Omar, Teresa Arora, Linda Ostlundh, Reshma Ramaraj, Syed Javaid, Romona Devi Govender, Bassam R. Ali, George P. Patrinos, Allan H. Young, Emmanuel Stip
Summary: Pharmacogenomic tests based on CYP2D6 and CYP2C19 genomic variants can guide the choice and dosing of antidepressants, improving treatment outcomes for major depressive disorders. A meta-analysis study demonstrated the effectiveness of these tests in improving, responding to, and achieving remission in patients with major depression.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Health Care Sciences & Services
Kiera Stein, Abdullah Al Maruf, Daniel J. Mueller, Jeffrey R. Bishop, Chad A. Bousman
Summary: Carriers of the 5-HTTLPR LL or LS genotypes were more likely to respond to antidepressant therapy, and relative to SS carriers, long (L) allele carriers taking SSRIs reported fewer ADRs.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Medicine, General & Internal
Rachel Wurth, Michelle Hajdenberg, Francisco J. Barrera, Skand Shekhar, Caroline E. Copacino, Pablo J. Moreno-Pena, Omar A. M. Gharib, Forbes Porter, Swapnil Hiremath, Janet E. Hall, Ernesto L. Schiffrin, Graeme Eisenhofer, Stefan R. Bornstein, Juan P. Brito, Jose Gerardo Gonzalez-Gonzalez, Constantine A. Stratakis, Rene Rodriguez-Gutierrez, Fady Hannah-Shmouni
Summary: The study revealed that the methodological and reporting quality of current COVID-19 systematic reviews is far from optimal, with most studies failing to address threats to their internal validity, such as repeated patient populations and heterogeneity in the definition of severe COVID-19. Adherence to proper study design and peer-review practices is necessary to mitigate these limitations.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Neurosciences
Prabhjot Dhami, Lena C. Quilty, Benjamin Schwartzmann, Rudolf Uher, Timothy A. Allen, Stefan Kloiber, Raymond W. Lam, Glenda MacQueen, Benicio N. Frey, Roumen Milev, Daniel J. Mueller, Stephen C. Strother, Pierre Blier, Claudio N. Soares, Sagar V. Parikh, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Faranak Farzan
Summary: The neurobiological correlates of response inhibition can predict the response of patients with major depressive disorder (MDD) to pharmacological and cognitive behavioral therapy treatment. The integrity of response inhibition may be crucial for the success of treatment for MDD. Electrophysiological correlates of response inhibition may serve as a general prognostic marker for treatment response in MDD.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Review
Clinical Neurology
Oloruntoba J. Oluboka, Martin A. Katzman, Jeffrey Habert, Atul Khullar, Margaret A. Oakander, Diane McIntosh, Roger S. McIntyre, Claudio N. Soares, Raymond W. Lam, Larry J. Klassen, Robert Tanguay
Summary: Major depressive disorder (MDD) is the leading cause of disability worldwide, and comorbid chronic pain exacerbates disability and healthcare burden. Managing patients with both MDD and chronic pain can be challenging due to shared underlying mechanisms. Current treatment guidelines address comorbid conditions such as anxiety and cardiovascular disease, but not chronic pain. Rapidly and aggressively treating depression according to guideline recommendations, using antidepressants with analgesic properties, while also addressing pain, is recommended based on clinical experience.
Article
Endocrinology & Metabolism
Osnat C. Melamed, Sumeet Kalia, Rahim Moineddin, Michelle Greiver, Stefan Kloiber, Benoit H. Mulsant, Peter Selby, Braden G. O'Neill
Summary: This study aims to identify demographic, socioeconomic and medical factors associated with the initiation of antidepressant medication in adult patients with diabetes. The study found that younger age, female gender, insulin treatment, and polypharmacy were associated with higher odds of antidepressant initiation. Patients also had increased visits to primary care after antidepressant initiation.
CANADIAN JOURNAL OF DIABETES
(2023)
Article
Pharmacology & Pharmacy
Roseann S. Gammal, Munir Pirmohamed, Andrew A. Somogyi, Sarah A. Morris, Christine M. Formea, Amanda L. Elchynski, Kazeem A. Oshikoya, Howard L. McLeod, Cyrine E. Haidar, Michelle Whirl-Carrillo, Teri E. Klein, Kelly E. Caudle, Mary Relling
Summary: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with the development of acute hemolytic anemia in the presence of oxidative stress. This guideline provides information on using G6PD genotype for diagnosing G6PD deficiency and categorizes medications based on their risk level in individuals with G6PD deficiency. High-risk medications should be avoided, medium-risk medications should be used with caution, and low-risk medications can be used without considering the G6PD phenotype.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Psychology, Clinical
Mehri Sajjadian, Rudolf Uher, Keith Ho, Stefanie Hassel, Roumen Milev, Benicio N. Frey, Faranak Farzan, Pierre Blier, Jane A. Foster, Sagar Parikh, Daniel J. Mueller, Susan Rotzinger, Claudio N. Soares, Gustavo Turecki, Valerie H. Taylor, Raymond W. Lam, Stephen C. Strother, Sidney H. Kennedy
Summary: Predicting treatment outcomes for major depressive disorder can be improved by combining clinical, neuroimaging, and molecular data. Early measurement during treatment can increase precision, but adding more features does not necessarily enhance prediction accuracy.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Cynthia H. Y. Fu, Guray Erus, Yong Fan, Mathilde Antoniades, Danilo Arnone, Stephen R. Arnott, Taolin Chen, Ki Sueng Choi, Cherise Chin Fatt, Benicio N. Frey, Vibe G. Frokjaer, Melanie Ganz, Jose Garcia, Beata R. Godlewska, Stefanie Hassel, Keith Ho, Andrew M. McIntosh, Kun Qin, Susan Rotzinger, Matthew D. Sacchet, Jonathan Savitz, Haochang Shou, Ashish Singh, Aleks Stolicyn, Irina Strigo, Stephen C. Strother, Duygu Tosun, Teresa A. Victor, Dongtao Wei, Toby Wise, Rachel D. Woodham, Roland Zahn, Ian M. Anderson, J. F. William Deakin, Boadie W. Dunlop, Rebecca Elliott, Qiyong Gong, Ian H. Gotlib, Catherine J. Harmer, Sidney H. Kennedy, Gitte M. Knudsen, Helen S. Mayberg, Martin P. Paulus, Jiang Qiu, Madhukar H. Trivedi, Heather C. Whalley, Chao-Gan Yan, Allan H. Young, Christos Davatzikos
Summary: In this study, a consortium called "COORDINATE-MDD" was established to define patterns of brain alteration in major depressive disorder (MDD) using neuroanatomical and neurofunctional heterogeneity as dimensions. By harmonizing imaging data and using machine learning methods, the project aims to predict treatment response at the individual level. International datasets from various MDD populations are being shared, and novel predictors of treatment response are being identified and validated externally.
Article
Psychiatry
Farhana Islam, Leen Magarbeh, Samar S. M. Elsheikh, Stefan Kloiber, Caroline W. Espinola, Venkat Bhat, Benicio N. Frey, Roumen Milev, Claudio N. Soares, Sagar V. Parikh, Franca Placenza, Stefanie Hassel, Valerie H. Taylor, Francesco Leri, Pierre Blier, Rudolf Uher, Faranak Farzan, Raymond W. Lam, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Daniel J. Mueller
Summary: Treatment-emergent sexual dysfunction is a common issue in individuals with major depressive disorder on antidepressants. This study found that polymorphisms in genes encoding drug-metabolizing enzymes and the transmembrane efflux pump were associated with changes in sexual function and satisfaction. Specifically, CYP2C19 metabolizer phenotypes were linked to changes in sexual arousal, and higher concentrations of the escitalopram metabolite, S-desmethylcitalopram, were associated with a decline in sexual function and satisfaction in females.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Meeting Abstract
Neurosciences
Nikita Nogovitsyn, Laura Fiori, Sakina J. Rizvi, Amanda K. Ceniti, Pedro Ballester, Jane A. Foster, Katharine Dunlop, Keith Ho, Stefanie Hassel, Roumen V. Milev, Claudio N. Soares, Stephen C. Strother, Stephen R. Arnott, Raymond W. Lam, Rudolf Uher, Sagar V. Parikh, Faranak Farzan, Valerie H. Taylor, Glenda MacQueen, Daniel J. Mueller, Gustavo Turecki, Susan Rotzinger, Benicio N. Frey, Sidney H. Kennedy
BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Pedro L. L. Ballester, Jee Su Suh, Natalie C. W. Ho, Liangbing Liang, Stefanie C. Hassel, Stephen C. C. Strother, Stephen R. R. Arnott, Luciano Minuzzi, Roberto B. B. Sassi, Raymond W. W. Lam, Roumen Milev, Daniel J. J. Mueller, Valerie H. H. Taylor, Sidney H. H. Kennedy, James P. P. Reilly, Lena Palaniyappan, Katharine Dunlop, Benicio N. N. Frey
Summary: Neuroimaging-based brain age is a biomarker generated through machine learning predictions, showing a higher brain age in individuals with schizophrenia. The specific factors driving these predictions and their biological interpretations are still not well understood.
Article
Psychiatry
Helena K. Kim, Vanessa F. Gonsalves, Muhammad I. Husain, Daniel J. Mueller, Benoit H. Mulsant, Gwyneth Zai, Stefan Kloiber
Summary: The study investigates the association between the endocannabinoid system (ECS) and multiple mental disorders using a cross-disorder genome-wide association study (GWAS) meta-analysis. The findings suggest that the ECS may be a shared pathway in mental disorders. Nine single nucleotide polymorphisms (SNPs) were identified as significantly associated with a change in risk of having a mental disorder, with the DAGLA gene showing the strongest association.
PSYCHIATRY RESEARCH
(2023)
