Article
Biochemistry & Molecular Biology
Ana Gabrielle Bispo, Caio S. Silva, Camille Sena-dos-Santos, Dafne Dalledone Moura, Brenda Hanae Bentes Koshimoto, Bruno Lopes Santos-Lobato, Andrea Ribeiro-dos-Santos, Giovanna C. Cavalcante
Summary: Mitophagy dysfunction caused by gene mutations is associated with the development of Parkinson's Disease (PD). However, the association between the variants of mitophagy-related genes and the treatment with levodopa (LD) in PD patients has not been well explored. This study investigated the association of 14 variants of the PRKN gene with LD treatment in PD patients. The results suggest that while age at onset of symptoms, duration of PD, and LD treatment and dosage can influence the occurrence of dyskinesia, the investigated PRKN variants did not show a significant association.
Review
Pharmacology & Pharmacy
Alexander V. Blagov, Andrey G. Goncharov, Olga O. Babich, Viktoriya V. Larina, Alexander N. Orekhov, Alexandra A. Melnichenko
Summary: This review discusses the use of mitophagy activators as a class of drug compounds for the treatment of Parkinson's disease, and explores the impact of mutations in Pink1 and Parkin enzymes on mitophagy.
Article
Biochemistry & Molecular Biology
Agnese Gugliandolo, Santino Blando, Stefano Salamone, Federica Pollastro, Emanuela Mazzon, Simone D'Angiolini
Summary: In this study, the potential protective effects of cannabinol (CBN) pre-treatment against mitochondria impairment in a Parkinson's disease model were evaluated. The results showed that CBN was able to counteract the changes in gene expression related to mitochondria function caused by neurodegeneration, particularly in the process of mitophagy mediated by PINK1/Parkin signaling pathway.
Article
Chemistry, Multidisciplinary
Xiaoyu Xia, Han Li, Xianbing Xu, Guanghua Zhao, Ming Du
Summary: The pathogenesis of Parkinson's disease is related to impaired mitochondrial function and abnormal mitophagy. Lycopene nanodots synthesized using recombinant human H-ferritin nanocages can protect neuronal mitochondrial function and promote the survival of dopaminergic neurons.
Review
Clinical Neurology
Kaitlyn M. L. Cramb, Dayne Beccano-Kelly, Stephanie J. Cragg, Richard Wade-Martins
Summary: Cramb et al. provide a review of evidence suggesting dopamine release deficits occur prior to neurodegeneration in Parkinson's disease. They also highlight the need for further investigation in understanding the mechanisms behind these deficits.
Article
Biochemistry & Molecular Biology
Ines Maestro, Laura R. de la Ballina, Anne Simonsen, Patricia Boya, Ana Martinez
Summary: In this study, two compounds were identified as inducers of Parkin-dependent mitophagy through a screening approach, and their ability to trigger mitophagy via Pink1/Parkin was proposed based on structure-activity relationship studies. These compounds showed promising therapeutic applicability in a cellular model of Parkinson's disease.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Plant Sciences
Ziying Wang, Jinshuai Cui, Dongni Li, Shuzhen Ran, Junqing Huang, Gang Chen
Summary: In this study, a natural compound called morin was found to promote mitophagy and have therapeutic effects on a Parkinson's disease mouse model. Morin acts by activating the AMPK-ULK1 pathway and promoting nuclear translocation of the mitophagy regulator TFEB. This research lays the foundation for the potential use of morin as a clinical drug for Parkinson's disease treatment.
Article
Clinical Neurology
Marc P. M. Soutar, Daniela Melandri, Benjamin O'Callaghan, Emily Annuario, Amy E. Monaghan, Natalie J. Welsh, Karishma D'Sa, Sebastian Guelfi, David Zhang, Alan Pittman, Daniah Trabzuni, Anouk H. A. Verboven, Kylie S. Pan, Demis A. Kia, Magda Bictash, Sonia Gandhi, Henry Houlden, Mark R. Cookson, Nael Nadif Kasri, Nicholas W. Wood, Andrew B. Singleton, John Hardy, Paul J. Whiting, Cornelis Blauwendraat, Alexander J. Whitworth, Claudia Manzoni, Mina Ryten, Patrick A. Lewis, Helene Plun-Favreau
Summary: Parkinson's disease is a common and incurable neurodegenerative disease. Genetic variants identified through genome-wide association studies have advanced our understanding of the disease's genetic risk. This study found that KANSL1 and KAT8 are regulators of PINK1-dependent mitophagy and may contribute to idiopathic Parkinson's disease.
Article
Neurosciences
David Nguyen, Vinita Bharat, Devon M. Conradson, Pawan Nandakishore, Xinnan Wang
Summary: The study identified the mitochondrial protein Miro1 as potentially a molecular marker for Parkinson's disease and at-risk individuals. The response of Miro1 to mitochondrial depolarization was significantly associated with PD risk, suggesting its potential use for detecting both PD and at-risk populations. Tracking the Miro1 marker could assist in diagnosis and Miro1-based drug discoveries.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Britney N. Lizama, Charleen T. Chu
Summary: Autophagy is crucial for cells to remove damaged components and is increasingly studied for its role in various diseases. Research on autophagy and mitochondrial quality control is expanding, particularly in relation to conditions like cancer, immune diseases, and neurodegenerative diseases.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Peter Kempster, Andrew Ma
Summary: A large proportion of drugs for neurological disorders are derived from naturally occurring compounds, especially plant alkaloids. The treatment of Parkinson's disease has strong botanical origins, with plant-derived substances playing a significant role. The interaction between plant compounds and animal dopaminergic systems has deep evolutionary roots.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
William Zhu, Xiaoping Huang, Esther Yoon, Sara Bandres-Ciga, Cornelis Blauwendraat, Kimberly J. Billingsley, Joshua H. Cade, Beverly P. Wu, Victoria H. Williams, Alice B. Schindler, Janet Brooks, J. Raphael Gibbs, Dena G. Hernandez, Debra Ehrlich, Andrew B. Singleton, Derek P. Narendra
Summary: Based on a comprehensive analysis of PRKN mutations, this study finds that heterozygous pathogenic PRKN mutations are common in the population but do not increase the risk of Parkinson's disease. This has implications for gene and cell replacement therapies for Parkinson's disease.
Article
Neurosciences
Shuangjie Qian, Haijun He, Xi Xiong, Ruixue Ai, Wenwen Wang, Huimin Zhu, Qianqian Ye, Shuoting Zhou, Hilde Nilsen, Chenglong Xie
Summary: This study reveals that plasma MAPs (PINK1, Parkin, and PGAM5) may serve as potentially useful diagnostic biomarkers for Parkinson's disease. However, further research on larger cohorts is needed to validate the association between elevated plasma MAP levels and PD risk or prognosis.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Cell Biology
Maria Vizziello, Linda Borellini, Giulia Franco, Gianluca Ardolino
Summary: Mitochondrial dysfunction is considered a major pathway in Parkinson's disease, and studies on genetic forms have revealed the roles of PINK1 and Parkin in mitochondrial homeostasis. The PINK1/Parkin pathway mediates the process of mitophagy, which is crucial for maintaining mitochondrial health.
Article
Pharmacology & Pharmacy
Yueqi Wang, Changjian Li, Xiaojie Zhang, Xiaoxuan Kang, Yaru Li, Wenyu Zhang, Yan Chen, Yang Liu, Weigang Wang, Maofa Ge, Libo Du
Summary: The study investigated the impact and mechanisms of PM2.5 exposure on PD symptoms using in vitro and in vivo models, revealing that PM2.5 aggravates behavioral abnormalities in PD by increasing oxidative stress, reducing autophagy and mitophagy levels, and inducing mitochondria-mediated neuronal apoptosis.
Article
Biochemistry & Molecular Biology
Guglielmo Vesco, Marta Lualdi, Mauro Fasano, Luca Nardo, Tiziana Alberio
Summary: The study provides direct evidence of binding interaction between FcRn and fibrinogen at acidic pH, suggesting a protective mechanism for fibrinogen from degradation and regulation of its plasma levels. This interaction may also impact the levels of other FcRn binding partners, including clinically relevant plasma proteins.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Simona Feno, Rosario Rizzuto, Anna Raffaello, Denis Vecellio Reane
Summary: The discovery of the Mitochondrial Calcium Uniporter (MCU) gene in 2011 led to an explosion of studies on the composition, regulation, and pathophysiological roles of the MCU complex. Recent research has provided new insights into the molecular structure and composition of the MCU complex, as well as the mechanisms that regulate MCU channel activity.
Article
Cell Biology
Agnese De Mario, Gaia Gherardi, Rosario Rizzuto, Cristina Mammucari
Summary: This review discusses the crucial role of mitochondria in skeletal muscle, including providing energy for endurance workload and maintaining cellular homeostasis through mitochondrial dynamics, turnover, and metabolism. Dysfunctional mitochondria can trigger myopathy, highlighting the importance of mitochondrial health in muscle function.
Article
Genetics & Heredity
Alessandra Zito, Marta Lualdi, Paola Granata, Dario Cocciadiferro, Antonio Novelli, Tiziana Alberio, Rosario Casalone, Mauro Fasano
Summary: Gene set enrichment analysis (GSEA) is a powerful tool to associate disease phenotypes with a group of genes/proteins. Utilizing betweenness centrality of a protein-protein interaction (PPI) network for GSEA can overcome the limitation of missing expression data, leading to new insights in neurodevelopmental disorders and neurodegenerative diseases research.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Gaia Butera, Denis Vecellio Reane, Marta Canato, Laura Pietrangelo, Simona Boncompagni, Feliciano Protasi, Rosario Rizzuto, Carlo Reggiani, Anna Raffaello
Summary: PV is a cytosolic Ca2+-binding protein highly expressed in fast skeletal muscle, contributing to relaxation rate and downregulated in muscle atrophy conditions. Mice lacking PV showed partial counteraction of muscle loss after denervation. PV ablation has a minor impact on sarcoplasmic reticulum but is associated with increased mitochondrial Ca2+ uptake, mitochondrial size and number, and contacts with Ca2+ release sites. These results suggest that mitochondrial Ca2+ uptake is required for hypertrophy and enhancement of pro-hypertrophy gene expression.
Article
Cell Biology
Agnese De Mario, Anna Tosatto, Julia Marie Hill, Janos Kriston-Vizi, Robin Ketteler, Denis Vecellio Reane, Gino Cortopassi, Gyorgy Szabadkai, Rosario Rizzuto, Cristina Mammucari
Summary: In this study, amorolfine and benzethonium were identified as positive and negative modulators of the mitochondrial calcium uniporter (MCU), demonstrating their potential roles in muscle development and cancer progression.
Review
Biochemistry & Molecular Biology
Giorgia Pallafacchina, Sofia Zanin, Rosario Rizzuto
Summary: Advances in scientific research have led to increasing interest in the regulation and physiological role of mitochondrial Ca2+ signaling, with the discovery and characterization of genes and pathways involved in recent years. The identification of the mitochondrial channel components and their function over the past decade has provided a clearer understanding of the role of mitochondrial Ca2+ signals in cellular processes. Recent studies have highlighted the importance of the MCU complex in controlling muscle nutrition and metabolism.
Review
Pharmacology & Pharmacy
Vanessa Checchetto, Luigi Leanza, Diego De Stefani, Rosario Rizzuto, Erich Gulbins, Ildiko Szabo
Summary: The field of mitochondrial ion channels has rapidly developed in the past decade due to molecular identification and specific pharmacological targeting. Despite challenges in genetic manipulation of mitochondrial K+ channels, they are recognized to play important roles in various pathologies and are druggable targets for potential therapeutic interventions. The in-depth investigation of mitochondrial potassium channels may lead to the development of innovative small molecules with significant therapeutic potential.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Daniela Basso, Ada Aita, Filippo Navaglia, Paola Mason, Stefania Moz, Alessio Pinato, Barbara Melloni, Luca Iannelli, Andrea Padoan, Chiara Cosma, Angelo Moretto, Alberto Scuttari, Daniela Mapelli, Rosario Rizzuto, Mario Plebani
Summary: Salivary-based surveillance with contact tracing effectively allowed to limit SARS-CoV-2 contagion, also in a population with a high incidence.
Article
Multidisciplinary Sciences
Eva M. Garcia-Cuesta, Jose Miguel Rodriguez-Frade, Sofia R. Gardeta, Gianluca D'Agostino, Pablo Martinez, Blanca Soler Palacios, Graciela Cascio, Tobias Wolf, Nicolas Mateos, Rosa Ayala-Bueno, Cesar A. Santiago, Pilar Lucas, Lucia Llorente, Luis M. Allende, Luis Ignacio Gonzalez-Granado, Noa Martin-Cofreces, Pedro Roda-Navarro, Federica Sallusto, Francisco Sanchez-Madrid, Maria F. Garcia-Parajo, Laura Martinez-Munoz, Mario Mellado
Summary: This study reveals that the truncated mutant chemokine receptor CXCR4(R334X) associated with WHIM syndrome fails to nanoclusterize after CXCL12 stimulation, affecting cell spatial organization and mobility, and causing multiple phalloidin-positive protrusions in cells. The inappropriate activation of beta-arrestin1 by CXCR4(R334X) leads to inadequate actin cytoskeleton remodeling, disrupting the balance between activated and deactivated cofilin.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Sara Montagnese, Lisa Zarantonello, Chiara Formentin, Gianluca Giusti, Chiara Mangini, Cheryl M. Isherwood, Paolo Ferrari, Antonio Paoli, Daniela Mapelli, Rosario Rizzuto, Stefano Toppo, Debra J. Skene, Roberto Vettor, Rodolfo Costa
Summary: The study aimed to assess sleep quality and timing in a group of university students and evaluate the effects of a circadian hygiene education initiative. It was found that most students had poor sleep quality, but those who joined during the lockdown period had better sleep quality. The circadian hygiene advice influenced students' wake-up times significantly but did not affect sleep duration. The events in 2020 had a significant impact on sleep quality and timing.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Enrico Zampese, David L. Wokosin, Patricia Gonzalez-Rodriguez, Jaime N. Guzman, Tatiana Tkatch, Jyothisri Kondapalli, William C. Surmeier, Karis B. D'Alessandro, Diego De Stefani, Rosario Rizzuto, Masamitsu Iino, Jeffery D. Molkentin, Navdeep S. Chandel, Paul T. Schumacker, D. James Surmeier
Summary: This study investigates the mechanism of how dopaminergic neurons sustain spike activity by stimulating mitochondrial oxidative phosphorylation through two complementary calcium-dependent mechanisms. However, this control mechanism also leads to increased oxidative stress in the neurons and may contribute to their decline with aging and disease.
Review
Biochemistry & Molecular Biology
Tiziana Alberio, Martina Brughera, Marta Lualdi
Summary: The growing number of patients affected by neurodegenerative disorders presents a significant challenge for healthcare systems, society, and the economy. Italian proteomics researchers have made valuable contributions to the understanding of these diseases and the discovery of biomarkers through the study of disease pathobiology and the development of novel platforms for biomarker discovery.
Review
Biochemistry & Molecular Biology
Adeena Shafique, Martina Brughera, Marta Lualdi, Tiziana Alberio
Summary: Mitochondrial dysfunction and vesicular trafficking alterations are involved in the pathogenesis of various neurodegenerative diseases. Impaired mitophagy and vesicle formation contribute to the dysregulation of neuronal homeostasis and neuronal cell death. Rab proteins play a central role in mitochondrial quality control and disposal through both canonical PINK1/Parkin-mediated mitophagy and novel alternative pathways. Understanding the sequential order of events and molecular factors involved in these processes is crucial for unraveling the molecular basis of neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
L. Azzi, V. Maurino, A. Baj, M. Dani, A. d'Aiuto, M. Fasano, M. Lualdi, F. Sessa, T. Alberio
Summary: The diagnosis of SARS-CoV-2 infection often relies on detecting viral RNA through real-time reverse transcription polymerase chain reaction (rRT-PCR) with respiratory specimens such as nasopharyngeal swabs. However, studies have suggested the use of saliva as an alternative due to its ease of collection, lack of specialized personnel needed, and reduced risk for operators. New saliva-based tests, including rapid antigen tests like the Rapid Salivary Test, offer quick and convenient options for detecting the virus outside of traditional laboratory settings.
JOURNAL OF DENTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
