Skeletal muscle mitochondria in health and disease

Visualizing and Modulating Mitophagy for Therapeutic Studies of Neurodegeneration

(2020) Hiroyuki Katayama et al.   CELL

Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation

(2020) Maude Dulac et al.   JOURNAL OF PHYSIOLOGY-LONDON

Fibroblast growth factor 21 controls mitophagy and muscle mass

(2019) Lynette J. Oost et al.   Journal of Cachexia Sarcopenia and Muscle

Crosstalk between Calcium and ROS in Pathophysiological Conditions

(2019) Simona Feno et al.   Oxidative Medicine and Cellular Longevity

DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass

(2019) Giulia Favaro et al.   Nature Communications

The Link of the Prion Protein with Ca2+ Metabolism and ROS Production, and the Possible Implication in Aβ Toxicity

(2019) Agnese De Mario et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1

(2019) Valentina Debattisti et al.   Cell Reports

Skeletal muscle mTORC1 regulates neuromuscular junction stability

(2019) Martina Baraldo et al.   Journal of Cachexia Sarcopenia and Muscle

In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy

(2018) Bojana Kravic et al.   Autophagy

Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency

(2018) Aida Rodríguez‐Nuevo et al.   EMBO JOURNAL

Proteomic profiling of skeletal and cardiac muscle in cancer cachexia: alterations in sarcomeric and mitochondrial protein expression

(2018) Angie M. Y. Shum et al.   Oncotarget

Role of Parkin and endurance training on mitochondrial turnover in skeletal muscle

(2018) Chris Chin Wah Chen et al.   Skeletal Muscle

Maintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging

(2018) David A. Hood et al.   Annual Review of Physiology

Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference

(2018) Gaia Gherardi et al.   CELL DEATH AND DIFFERENTIATION

Impaired proteostasis during skeletal muscle aging

(2018) Raquel Fernando et al.   FREE RADICAL BIOLOGY AND MEDICINE

Preservation of muscle mass as a strategy to reduce the toxic effects of cancer chemotherapy on body composition

(2018) Fabrizio Pin et al.   Current Opinion in Supportive and Palliative Care

Altered mitochondrial quality control signaling in muscle of old gastric cancer patients with cachexia

(2017) Emanuele Marzetti et al.   EXPERIMENTAL GERONTOLOGY

The prion protein regulates glutamate-mediated Ca2+entry and mitochondrial Ca2+accumulation in neurons

(2017) Agnese De Mario et al.   JOURNAL OF CELL SCIENCE

Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control

(2017) Yaoshan Dun et al.   Oxidative Medicine and Cellular Longevity

Autophagy-Dependent Beneficial Effects of Exercise

(2017) Jens Frey Halling et al.   Cold Spring Harbor Perspectives in Medicine

Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice

(2017) Jacob L. Brown et al.   Journal of Cachexia Sarcopenia and Muscle

Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal

(2017) Michael D. Tarpey et al.   Molecular Metabolism

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

The VDAC channel: Molecular basis for selectivity

(2016) Marco Colombini   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

(2016) David Sebastián et al.   EMBO JOURNAL

Role of reactive oxygen species in age-related neuromuscular deficits

(2016) Malcolm J. Jackson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

High-throughput discovery of novel developmental phenotypes

(2016) Mary E. Dickinson et al.   NATURE

Altered skeletal muscle (mitochondrial) properties in patients with mitochondrial DNA single deletion myopathy

(2016) Saskia Maria Gehrig et al.   Orphanet Journal of Rare Diseases

The emerging role of skeletal muscle oxidative metabolism as a biological target and cellular regulator of cancer-induced muscle wasting

(2016) James A. Carson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Spectrum of Mitochondrial Ultrastructural Defects in Mitochondrial Myopathy

(2016) Amy E. Vincent et al.   Scientific Reports

Mitochondrial dysfunctions during progression of dystrophic cardiomyopathy

(2015) Victoria Kyrychenko et al.   CELL CALCIUM

Genetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophy

(2015) A R Burr et al.   CELL DEATH AND DIFFERENTIATION

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

(2015) Tatiana Varanita et al.   Cell Metabolism

Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models

(2015) Gabriele Civiletto et al.   Cell Metabolism

The Ins and Outs of Mitochondrial Calcium

(2015) T. Finkel et al.   CIRCULATION RESEARCH

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation

(2015) T Touvier et al.   Cell Death & Disease

The Mitochondrial Calcium Uniporter Controls Skeletal Muscle Trophism In Vivo

(2015) Cristina Mammucari et al.   Cell Reports

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux

(2014) Elena De Marchi et al.   CELL CALCIUM

Mitochondrial myopathies in adults and children

(2014) Robert D.S. Pitceathly et al.   CURRENT OPINION IN NEUROLOGY

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

Defects in Mitochondrial ATP Synthesis in Dystrophin-Deficient Mdx Skeletal Muscles May Be Caused by Complex I Insufficiency

(2014) Emma Rybalka et al.   PLoS One

Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

(2014) Silvia Carnio et al.   Cell Reports

Inflammation Based Regulation of Cancer Cachexia

(2014) Jill K. Onesti et al.   Biomed Research International

Autophagic Degradation Contributes to Muscle Wasting in Cancer Cachexia

(2013) Fabio Penna et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance

(2013) Vitor A. Lira et al.   FASEB JOURNAL

Bladder cancer-induced skeletal muscle wasting: Disclosing the role of mitochondria plasticity

(2013) Ana Isabel Padrão et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle

(2013) Martin Picard et al.   JOURNAL OF APPLIED PHYSIOLOGY

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

(2013) Clare V Logan et al.   NATURE GENETICS

The clinical maze of mitochondrial neurology

(2013) Salvatore DiMauro et al.   Nature Reviews Neurology

AMPK Activation Stimulates Autophagy and Ameliorates Muscular Dystrophy in the mdx Mouse Diaphragm

(2012) Marion Pauly et al.   AMERICAN JOURNAL OF PATHOLOGY

A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy

(2012) Jorge L. Ruas et al.   CELL

Chronic Caloric Restriction Preserves Mitochondrial Function in Senescence without Increasing Mitochondrial Biogenesis

(2012) Ian R. Lanza et al.   Cell Metabolism

Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival MitophagyversusApoptosis

(2012) Yanyan Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome proliferator-activated receptor γ coactivator 1-α gene transfer restores mitochondrial biomass and improves mitochondrial calcium handling in post-necroticmdxmouse skeletal muscle

(2012) Richard Godin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults

(2012) Paul M. Coen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model

(2012) Vanessa E Jahnke et al.   Skeletal Muscle

Measuring mitochondrial respiration in intact single muscle fibers

(2011) Rosemary A. Schuh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover

(2011) S Rikka et al.   CELL DEATH AND DIFFERENTIATION

A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

(2011) Hiroyuki Katayama et al.   CHEMISTRY & BIOLOGY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Cyclosporine A in Ullrich Congenital Muscular Dystrophy: Long-Term Results

(2011) Luciano Merlini et al.   Oxidative Medicine and Cellular Longevity

Mutation of the Mitochondrial Tyrosyl-tRNA Synthetase Gene, YARS2, Causes Myopathy, Lactic Acidosis, and Sideroblastic Anemia—MLASA Syndrome

(2010) Lisa G. Riley et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Isolated Distal Myopathy of the Upper Limbs Associated With Mitochondrial DNA Depletion and Polymerase γ Mutations

(2010) Carla Giordano et al.   ARCHIVES OF NEUROLOGY

Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder—murine Pompe disease

(2010) Nina Raben et al.   Autophagy

Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations

(2010) Hsiuchen Chen et al.   CELL

Mitochondrial fission and remodelling contributes to muscle atrophy

(2010) Vanina Romanello et al.   EMBO JOURNAL

Interleukin 6 as a Key Regulator of Muscle Mass during Cachexia

(2010) James A. Carson et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Mutation in dystrophin-encoding gene affects energy metabolism in mouse myoblasts

(2009) Marta Onopiuk et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID Trial), a First-in-Human Phase 1/2 Clinical Trial

(2009) Brian E. Jaski et al.   JOURNAL OF CARDIAC FAILURE

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

(2009) Junko Wakabayashi et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions

(2009) G Chinnadurai et al.   ONCOGENE

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

(2008) Douglas P Millay et al.   NATURE MEDICINE

Autosomal recessive myosclerosis myopathy is a collagen VI disorder

(2008) L. Merlini et al.   NEUROLOGY