Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter

A High-Throughput Screening Identifies MICU1 Targeting Compounds

(2020) Giulia Di Marco et al.   Cell Reports

The role of mitochondrial reactive oxygen species, NO and H 2 S in ischaemia/reperfusion injury and cardioprotection

(2020) Ioanna Andreadou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ca2+ Fluxes and Cancer

(2020) Saverio Marchi et al.   MOLECULAR CELL

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

(2019) Joshua J. Woods et al.   ACS Central Science

Mitochondrial calcium uniporter complex modulation in cancerogenesis

(2019) Saverio Marchi et al.   CELL CYCLE

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

(2019) Alyssa A. Lombardi et al.   Nature Communications

Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1

(2019) Valentina Debattisti et al.   Cell Reports

RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+Uptake and Promotes Colorectal Oncogenesis

(2018) Fanxin Zeng et al.   CANCER RESEARCH

Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference

(2018) Gaia Gherardi et al.   CELL DEATH AND DIFFERENTIATION

In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride

(2017) Sandipan Datta et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening

(2017) Daniela M. Arduino et al.   MOLECULAR CELL

MCU-dependent mitochondrial Ca2+ inhibits NAD+/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells

(2017) T Ren et al.   ONCOGENE

Mitochondrial redox signaling enables repair of injured skeletal muscle cells

(2017) Adam Horn et al.   Science Signaling

Mitochondrial calcium uniporter as a target of microRNA-340 and promoter of metastasis via enhancing the Warburg effect

(2017) Changhui Yu et al.   Oncotarget

Mitochondrial redox signaling enables repair of injured skeletal muscle cells

(2017) Adam Horn et al.   Science Signaling

The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α

(2016) Anna Tosatto et al.   EMBO Molecular Medicine

Mitochondrial Ca2+ uniporter is critical for store-operated Ca2+ entry-dependent breast cancer cell migration

(2015) Shihao Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Mitochondrial Calcium Uniporter Controls Skeletal Muscle Trophism In Vivo

(2015) Cristina Mammucari et al.   Cell Reports

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Reports

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Red fluorescent genetically encoded indicator for intracellular hydrogen peroxide

(2014) Yulia G. Ermakova et al.   Nature Communications

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

(2013) Clare V Logan et al.   NATURE GENETICS

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25

(2012) Saverio Marchi et al.   CURRENT BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Real-time imaging of the intracellular glutathione redox potential

(2008) Marcus Gutscher et al.   NATURE METHODS