Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1

(2015) Julie S. Barber-Rotenberg et al.   Oncotarget

ETS transcription factors in hematopoietic stem cell development

(2013) Aldo Ciau-Uitz et al.   BLOOD CELLS MOLECULES AND DISEASES

Review of Ets1 structure, function, and roles in immunity

(2013) Lee Ann Garrett-Sinha   CELLULAR AND MOLECULAR LIFE SCIENCES

Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer

(2013) Sven Bilke et al.   GENOME RESEARCH

ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss

(2013) Yu Chen et al.   NATURE MEDICINE

Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited

(2013) M. C. Regan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoinhibition of ETV6 (TEL) DNA Binding: Appended Helices Sterically Block the ETS Domain

(2012) H. Jerome Coyne et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines

(2012) Raja Nhili et al.   NUCLEIC ACIDS RESEARCH

Structural Basis of Ets1 Cooperative Binding to Widely Separated Sites on Promoter DNA

(2012) Nigar D. Babayeva et al.   PLoS One

The PNT domain fromDrosophilapointed-P2 contains a dynamic N-terminal helix preceded by a disordered phosphoacceptor sequence

(2012) Desmond K. W. Lau et al.   PROTEIN SCIENCE

Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors

(2011) Peter C. Hollenhorst et al.   Annual Review of Biochemistry

Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer

(2011) J. Chad Brenner et al.   CANCER CELL

Dimer formation and conformational flexibility ensure cytoplasmic stability and nuclear accumulation of Elk-1

(2011) Emma L. Evans et al.   NUCLEIC ACIDS RESEARCH

YK-4-279 Inhibits ERG and ETV1 Mediated Prostate Cancer Cell Invasion

(2011) Said Rahim et al.   PLoS One

Molecular dynamics simulations and in silico peptide ligand screening of the Elk-1 ETS domain

(2011) Abrar Hussain et al.   Journal of Cheminformatics

An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression

(2010) Jindan Yu et al.   CANCER CELL

An Oncogenic Role for ETV1 in Melanoma

(2010) J. Jane-Valbuena et al.   CANCER RESEARCH

An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

(2010) Timothy Ravasi et al.   CELL

Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA

(2010) Nigar D. Babayeva et al.   CELL CYCLE

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo

(2010) Gong-Hong Wei et al.   EMBO JOURNAL

Small-molecule protein-protein interaction inhibitors: Therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations

(2010) Peter Buchwald   IUBMB LIFE

Induction of Prostatic Intraepithelial Neoplasia and Modulation of Androgen Receptor by ETS Variant 1/ETS-Related Protein 81

(2009) S. Shin et al.   CANCER RESEARCH

FGF-Regulated Etv Genes Are Essential for Repressing Shh Expression in Mouse Limb Buds

(2009) Zhen Zhang et al.   DEVELOPMENTAL CELL

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

(2009) Hayriye V Erkizan et al.   NATURE MEDICINE

DNA Specificity Determinants Associate with Distinct Transcription Factor Functions

(2009) Peter C. Hollenhorst et al.   PLoS Genetics

Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization

(2008) Ekaterina P Lamber et al.   EMBO JOURNAL

Interaction between the homeodomain protein HOXC13 and ETS family transcription factor PU.1 and its implication in the differentiation of murine erythroleukemia cells

(2007) Toshiyuki Yamada et al.   EXPERIMENTAL CELL RESEARCH