Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Molecular Basis for Fe(III)-Independent Curcumin Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Activity

(2015) Guangyu Wang   BIOCHEMISTRY

Functional Architecture of the Cytoplasmic Entrance to the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore

(2015) Yassine El Hiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels

(2015) Luiz A. Poletto Chaves et al.   JOURNAL OF GENERAL PHYSIOLOGY

Localizing a gate in CFTR

(2015) Xiaolong Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational changes opening and closing the CFTR chloride channel: Insights from cysteine scanning mutagenesis

(2014) Yassine El Hiani et al.   Biochemistry and Cell Biology

Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics

(2014) Jean-Paul Mornon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An Electrostatic Interaction at the Tetrahelix Bundle Promotes Phosphorylation-dependent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channel Opening

(2014) Wei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal Bridges Illuminate Transmembrane Domain Movements during Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

(2014) Yassine El Hiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalyst-like modulation of transition states for CFTR channel opening and closing: New stimulation strategy exploits nonequilibrium gating

(2014) László Csanády et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

(2014) H. G. Choudhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis

(2014) Jessica LaRusch et al.   PLoS Genetics

Cysteine Scanning of CFTR’s First Transmembrane Segment Reveals Its Plausible Roles in Gating and Permeation

(2013) Xiaolong Gao et al.   BIOPHYSICAL JOURNAL

Origin and evolution of the cystic fibrosis transmembrane regulator protein R domain

(2013) Aswathy Sebastian et al.   GENE

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR

(2013) László Csanády et al.   JOURNAL OF GENERAL PHYSIOLOGY

Description of local and global shape properties of protein helices

(2013) Zhanyong Guo et al.   JOURNAL OF MOLECULAR MODELING

Functional architecture of the CFTR chloride channel

(2013) Paul Linsdell   MOLECULAR MEMBRANE BIOLOGY

Relative contribution of different transmembrane segments to the CFTR chloride channel pore

(2013) Wuyang Wang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Modeling the Conformational Changes Underlying Channel Opening in CFTR

(2013) Kazi S. Rahman et al.   PLoS One

Multiple Transport-Active Binding Sites Are Available for a Single Substrate on Human P-Glycoprotein (ABCB1)

(2013) Eduardo E. Chufan et al.   PLoS One

Chloride transport-driven alveolar fluid secretion is a major contributor to cardiogenic lung edema

(2013) E. A. Solymosi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

(2013) C. A. Shintre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

Cystic Fibrosis Transmembrane Conductance Regulator: A Molecular Model Defines the Architecture of the Anion Conduction Path and Locates a “Bottleneck” in the Pore

(2012) Yohei Norimatsu et al.   BIOCHEMISTRY

Conformational change opening the CFTR chloride channel pore coupled to ATP-dependent gating

(2012) Wuyang Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences

(2012) Juan L. Mendoza et al.   CELL

The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo

(2012) B B Hyde et al.   CELL DEATH AND DIFFERENTIATION

CFTR Inhibitors for Treating Diarrheal Disease

(2012) J R Thiagarajah et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Human Transporter Associated with Antigen Processing

(2012) Valentina Corradi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternating Access to the Transmembrane Domain of the ATP-binding Cassette Protein Cystic Fibrosis Transmembrane Conductance Regulator (ABCC7)

(2012) Wuyang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Model of Cystic Fibrosis Transmembrane Conductance Regulator Proposes Active Channel-like Conformation

(2012) James Dalton et al.   Journal of Chemical Information and Modeling

Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation

(2012) Michael Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Pharmacologic Approach to Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Smoking Related Lung Disease

(2012) Peter A. Sloane et al.   PLoS One

Definition and testing of the GROMOS force-field versions 54A7 and 54B7

(2011) Nathan Schmid et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore

(2011) Wuyang Wang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mutant cycles at CFTR’s non-canonical ATP-binding site support little interface separation during gating

(2011) Andras Szollosi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7)

(2011) Yonghong Bai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Functional arrangement of the 12th transmembrane region in the CFTR chloride channel pore based on functional investigation of a cysteine-less CFTR variant

(2011) Feng Qian et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Structural consequences of ATP hydrolysis on the ABC transporter NBD dimer: Molecular dynamics studies of HlyB

(2011) João M. Damas et al.   PROTEIN SCIENCE

Mild cystic fibrosis mutations in Southern Sweden with special reference to S549I and T338I

(2010) C. Schaedel et al.   CLINICAL GENETICS

Changes in Accessibility of Cytoplasmic Substances to the Pore Associated with Activation of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

(2010) Yassine El Hiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

(2010) Ming-Feng Tsai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation

(2010) Yonghong Bai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Dynamics and Structural Changes Induced by ATP Binding in SAV1866, a Bacterial ABC Exporter

(2010) Jean-Paul Becker et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Pore opening and closing of a pentameric ligand-gated ion channel

(2010) F. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant

(2010) Shane Atwell et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Asymmetric Switching in a Homodimeric ABC Transporter: A Simulation Study

(2010) Jussi Aittoniemi et al.   PLoS Computational Biology

Clustering of disease-causing mutations on the domain–domain interfaces of ABCC6

(2009) Krisztina Fülöp et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cystic Fibrosis Transmembrane Conductance Regulator: Using Differential Reactivity toward Channel-Permeant and Channel-Impermeant Thiol-Reactive Probes To Test a Molecular Model for the Pore

(2009) Christopher Alexander et al.   BIOCHEMISTRY

Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A

(2009) Tamás Hegedűs et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Molecular models of the open and closed states of the whole human CFTR protein

(2009) Jean-Paul Mornon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter

(2009) Erik Procko et al.   FASEB JOURNAL

The Conformational Transition Pathway of ATP Binding Cassette Transporter MsbA Revealed by Atomistic Simulations

(2009) Jing-Wei Weng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Dynamics of NBD1 from CFTR Characterized Using Crystallography and Hydrogen/Deuterium Exchange Mass Spectrometry

(2009) H.A. Lewis et al.   JOURNAL OF MOLECULAR BIOLOGY

Gating of the CFTR Cl−channel by ATP-driven nucleotide-binding domain dimerisation

(2009) Tzyh-Chang Hwang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cystic fibrosis

(2009) Brian P O'Sullivan et al.   LANCET

Ion channels versus ion pumps: the principal difference, in principle

(2009) David C. Gadsby   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations

(2009) L. Csanady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural arrangement of the transmission interface in the antigen ABC transport complex TAP

(2009) G. Oancea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Multidrug Transport by the ABC Transporter Sav1866 fromStaphylococcus aureus†

(2008) Saroj Velamakanni et al.   BIOCHEMISTRY

Atomic model of human cystic fibrosis transmembrane conductance regulator: Membrane-spanning domains and coupling interfaces

(2008) J.-P. Mornon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multiple Membrane-Cytoplasmic Domain Contacts in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mediate Regulation of Channel Gating

(2008) Lihua He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Mutations at the Signature Sequence of CFTR Create a Cd2+-gated Chloride Channel

(2008) Xiaohui Wang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mutations at Arginine 352 Alter the Pore Architecture of CFTR

(2008) Guiying Cui et al.   JOURNAL OF MEMBRANE BIOLOGY

Multiple Roles of Charged Amino Acids in Cytoplasmic Loop 7 for Expression and Function of the Multidrug and Organic Anion Transporter MRP1 (ABCC1)

(2008) G. Conseil et al.   MOLECULAR PHARMACOLOGY

Identification of positive charges situated at the outer mouth of the CFTR chloride channel pore

(2008) Jing-Jun Zhou et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

(2008) A. W. R. Serohijos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS