Conformational changes opening and closing the CFTR chloride channel: Insights from cysteine scanning mutagenesis

Cysteine Scanning of CFTR’s First Transmembrane Segment Reveals Its Plausible Roles in Gating and Permeation

(2013) Xiaolong Gao et al.   BIOPHYSICAL JOURNAL

CFTR: Effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel

(2013) Arnaud Billet et al.   Journal of Cystic Fibrosis

Functional architecture of the CFTR chloride channel

(2013) Paul Linsdell   MOLECULAR MEMBRANE BIOLOGY

Relative contribution of different transmembrane segments to the CFTR chloride channel pore

(2013) Wuyang Wang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Measuring Airway Surface Liquid Depth in Ex Vivo Mouse Airways by X-Ray Imaging for the Assessment of Cystic Fibrosis Airway Therapies

(2013) Kaye S. Morgan et al.   PLoS One

Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions

(2013) Z. Bozoky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Juxtamembrane Region of Cytoplasmic Loop 3 in the Gating and Conductance of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

(2012) Yassine El Hiani et al.   BIOCHEMISTRY

Conformational change opening the CFTR chloride channel pore coupled to ATP-dependent gating

(2012) Wuyang Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Tuning of CFTR Chloride Channel Function by Location of Positive Charges within the Pore

(2012) Yassine El Hiani et al.   BIOPHYSICAL JOURNAL

Alternating Access to the Transmembrane Domain of the ATP-binding Cassette Protein Cystic Fibrosis Transmembrane Conductance Regulator (ABCC7)

(2012) Wuyang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relative Movements of Transmembrane Regions at the Outer Mouth of the Cystic Fibrosis Transmembrane Conductance Regulator Channel Pore during Channel Gating

(2012) Wuyang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Model of Cystic Fibrosis Transmembrane Conductance Regulator Proposes Active Channel-like Conformation

(2012) James Dalton et al.   Journal of Chemical Information and Modeling

Nonequilibrium Gating of CFTR on an Equilibrium Theme

(2012) Kang-Yang Jih et al.   PHYSIOLOGY

Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore

(2011) Wuyang Wang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7)

(2011) Yonghong Bai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Functional arrangement of the 12th transmembrane region in the CFTR chloride channel pore based on functional investigation of a cysteine-less CFTR variant

(2011) Feng Qian et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

COMMD1-Mediated Ubiquitination Regulates CFTR Trafficking

(2011) Loïc Drévillon et al.   PLoS One

Changes in Accessibility of Cytoplasmic Substances to the Pore Associated with Activation of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

(2010) Yassine El Hiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation

(2010) Yonghong Bai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Regulation of conductance by the number of fixed positive charges in the intracellular vestibule of the CFTR chloride channel pore

(2010) Jing-Jun Zhou et al.   JOURNAL OF GENERAL PHYSIOLOGY

CFTR: Break a pump, make a channel

(2010) C. Miller   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP-independent CFTR channel gating and allosteric modulation by phosphorylation

(2010) Wei Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cystic Fibrosis Transmembrane Conductance Regulator: Using Differential Reactivity toward Channel-Permeant and Channel-Impermeant Thiol-Reactive Probes To Test a Molecular Model for the Pore

(2009) Christopher Alexander et al.   BIOCHEMISTRY

Molecular models of the open and closed states of the whole human CFTR protein

(2009) Jean-Paul Mornon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Novel Residues Lining the CFTR Chloride Channel Pore Identified by Functional Modification of Introduced Cysteines

(2009) Mohammad Fatehi et al.   JOURNAL OF MEMBRANE BIOLOGY

Gating of the CFTR Cl−channel by ATP-driven nucleotide-binding domain dimerisation

(2009) Tzyh-Chang Hwang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ion channels versus ion pumps: the principal difference, in principle

(2009) David C. Gadsby   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases

(2009) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations

(2009) L. Csanady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic model of human cystic fibrosis transmembrane conductance regulator: Membrane-spanning domains and coupling interfaces

(2008) J.-P. Mornon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanism of direct bicarbonate transport by the CFTR anion channel

(2008) Lin Tang et al.   Journal of Cystic Fibrosis

ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator

(2008) D. Muallem et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

(2008) A. W. R. Serohijos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA