Mutant cycles at CFTR’s non-canonical ATP-binding site support little interface separation during gating

Extent of Nucleotide-Binding Domain (NBD) Separation When a CFTR Channel Closes

(2011) Luiz Artur et al.   BIOPHYSICAL JOURNAL

Characterization of an Asymmetric Occluded State of P-glycoprotein with Two Bound Nucleotides

(2010) Alena Siarheyeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2

(2010) Andras Szollosi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

(2010) Ming-Feng Tsai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant

(2010) Shane Atwell et al.   PROTEIN ENGINEERING DESIGN & SELECTION

State-dependent modulation of CFTR gating by pyrophosphate

(2009) Ming-Feng Tsai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations

(2009) L. Csanady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimer Opening of the Nucleotide Binding Domains of ABC Transporters after ATP Hydrolysis

(2008) Po-Chao Wen et al.   BIOPHYSICAL JOURNAL

Atomic model of human cystic fibrosis transmembrane conductance regulator: Membrane-spanning domains and coupling interfaces

(2008) J.-P. Mornon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator

(2008) D. Muallem et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Structure and mechanism of ATP-binding cassette transporters

(2008) K. P Locher   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

(2008) A. W. R. Serohijos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opening of the ADP-bound active site in the ABC transporter ATPase dimer: Evidence for a constant contact, alternating sites model for the catalytic cycle

(2008) Peter M. Jones et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS