Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP2)

Novel signalling mechanism and clinical applications of sperm-specific PLCζ

(2015) Michail Nomikos   BIOCHEMICAL SOCIETY TRANSACTIONS

Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase Cζ

(2015) Randa Sanusi et al.   MOLECULAR HUMAN REPRODUCTION

Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca2+ release in mouse oocytes

(2014) M. Nomikos et al.   MOLECULAR HUMAN REPRODUCTION

Sperm PLCζ: From structure to Ca2+oscillations, egg activation and therapeutic potential

(2013) Michail Nomikos et al.   FEBS LETTERS

Ca2+-independent Binding of Anionic Phospholipids by Phospholipase C δ1 EF-hand Domain

(2013) Jingfei Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chimeras of sperm PLC  reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization

(2013) M. Theodoridou et al.   MOLECULAR HUMAN REPRODUCTION

Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility

(2012) Michail Nomikos et al.   FERTILITY AND STERILITY

Male infertility-linked point mutation disrupts the Ca2+oscillation-inducing and PIP2hydrolysis activity of sperm PLCζ

(2011) Michail Nomikos et al.   BIOCHEMICAL JOURNAL

Novel regulation of PLCζ activity via its XY-linker

(2011) Michail Nomikos et al.   BIOCHEMICAL JOURNAL

Starting a new life: Sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development

(2011) Michail Nomikos et al.   BIOESSAYS

A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC ) leads to male infertility

(2011) J. Kashir et al.   HUMAN REPRODUCTION

Phospholipase C  binding to PtdIns(4,5)P2 requires the XY-linker region

(2011) M. Nomikos et al.   JOURNAL OF CELL SCIENCE

PLCζ causes Ca2+ oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P2

(2011) Yuansong Yu et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes

(2010) Aurelie Gresset et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced amounts and abnormal forms of phospholipase C zeta (PLC ) in spermatozoa from infertile men

(2009) E. Heytens et al.   HUMAN REPRODUCTION

Human sperm devoid of PLC, zeta 1 fail to induce Ca2+ release and are unable to initiate the first step of embryo development

(2008) Sook-Young Yoon et al.   JOURNAL OF CLINICAL INVESTIGATION

General and Versatile Autoinhibition of PLC Isozymes

(2008) Stephanie N. Hicks et al.   MOLECULAR CELL