Journal
BIOCHEMICAL JOURNAL
Volume 434, Issue -, Pages 211-217Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20101772
Keywords
calcium oscillation; egg activation; fertilization; infertility; phospholipase C (PLC); phospholipase C zeta (PLC zeta)
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Funding
- Wellcome Trust [080701]
- Medical Research Council
- Libyan Government
- NCSR Demokritos
- Medical Research Council [G0801676] Funding Source: researchfish
- MRC [G0801676] Funding Source: UKRI
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A male infertility-linked human PLC zeta (phospholipase C zeta) mutation introduced into mouse PLC zeta completely abolishes both in vitro PIP2 (phosphatidylinositol 4,5-bisphosphate) hydrolysis activity and the ability to trigger in vivo Ca2+ oscillations in mouse eggs. Wild-type PLC zeta initiated a normal pattern of Ca2+ oscillations in eggs in the presence of 10-fold higher mutant PLC zeta, suggesting that infertility is not mediated by a dominant-negative mechanism.
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