Chimeras of sperm PLC  reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization

PLC? and the initiation of Ca2+ oscillations in fertilizing mammalian eggs

(2012) Karl Swann et al.   CELL CALCIUM

Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility

(2012) Michail Nomikos et al.   FERTILITY AND STERILITY

Male infertility-linked point mutation disrupts the Ca2+oscillation-inducing and PIP2hydrolysis activity of sperm PLCζ

(2011) Michail Nomikos et al.   BIOCHEMICAL JOURNAL

Divergent effect of mammalian PLCζ in generating Ca2+oscillations in somatic cells compared with eggs

(2011) Sally V. Phillips et al.   BIOCHEMICAL JOURNAL

Novel regulation of PLCζ activity via its XY-linker

(2011) Michail Nomikos et al.   BIOCHEMICAL JOURNAL

Starting a new life: Sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development

(2011) Michail Nomikos et al.   BIOESSAYS

Loss of activity mutations in phospholipase C zeta (PLC ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes

(2011) J. Kashir et al.   HUMAN REPRODUCTION

A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC ) leads to male infertility

(2011) J. Kashir et al.   HUMAN REPRODUCTION

Phospholipase C  binding to PtdIns(4,5)P2 requires the XY-linker region

(2011) M. Nomikos et al.   JOURNAL OF CELL SCIENCE

PLCζ causes Ca2+ oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P2

(2011) Yuansong Yu et al.   MOLECULAR BIOLOGY OF THE CELL

PLCζ and its role as a trigger of development in vertebrates

(2011) Junya Ito et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Oscillatory Ca2+ dynamics and cell cycle resumption at fertilization in mammals: a modelling approach

(2010) Genevive Dupont et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes

(2010) Aurelie Gresset et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced amounts and abnormal forms of phospholipase C zeta (PLC ) in spermatozoa from infertile men

(2009) E. Heytens et al.   HUMAN REPRODUCTION

Human sperm devoid of PLC, zeta 1 fail to induce Ca2+ release and are unable to initiate the first step of embryo development

(2008) Sook-Young Yoon et al.   JOURNAL OF CLINICAL INVESTIGATION

Modeling local and global intracellular calcium responses mediated by diffusely distributed inositol 1,4,5-trisphosphate receptors

(2008) George S.B. Williams et al.   JOURNAL OF THEORETICAL BIOLOGY

General and Versatile Autoinhibition of PLC Isozymes

(2008) Stephanie N. Hicks et al.   MOLECULAR CELL