TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt
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Title
TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt
Authors
Keywords
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Journal
BIOCHEMICAL JOURNAL
Volume 455, Issue 2, Pages 207-216
Publisher
Portland Press Ltd.
Online
2013-08-07
DOI
10.1042/bj20130760
References
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Related references
Note: Only part of the references are listed.- Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders
- (2013) Ruisheng Song et al. NATURE
- Ubiquitin and Membrane Protein Turnover: From Cradle to Grave
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- The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis
- (2012) Chia-Hsin Chan et al. CELL
- Hepatic TRAF2 Regulates Glucose Metabolism Through Enhancing Glucagon Responses
- (2012) Z. Chen et al. DIABETES
- Phosphorylation of Adaptor Protein Containing Pleckstrin Homology Domain, Phosphotyrosine Binding Domain, and Leucine Zipper Motif 1 (APPL1) at Ser430Mediates Endoplasmic Reticulum (ER) Stress-induced Insulin Resistance in Hepatocytes
- (2012) Meilian Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- APPL1 potentiates insulin secretion in pancreatic cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice
- (2012) K. K. Y. Cheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice
- (2011) Yi Wang et al. DIABETES
- Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment
- (2011) Iwona Pilecka et al. EXPERIMENTAL CELL RESEARCH
- The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway
- (2011) M E Cleasby et al. JOURNAL OF ENDOCRINOLOGY
- An Activating Mutation of AKT2 and Human Hypoglycemia
- (2011) K. Hussain et al. SCIENCE
- The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy
- (2011) N. R. Sundaresan et al. Science Signaling
- An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart
- (2010) Xiangping Fang et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes
- (2009) Roberto Zoncu et al. CELL
- APPL1 Potentiates Insulin-Mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice
- (2009) Kenneth K.Y. Cheng et al. Cell Metabolism
- The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation
- (2009) W.-L. Yang et al. SCIENCE
- The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development
- (2008) Annette Schenck et al. CELL
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