Munc18a Does Not Alter Fusion Rates Mediated by Neuronal SNAREs, Synaptotagmin, and Complexin

Synaptotagmin-1 Is an Antagonist for Munc18-1 in SNARE Zippering

(2015) Xiaochu Lou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molecular Machinery of Neurotransmitter Release (Nobel Lecture)

(2014) Thomas C. Südhof   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Extended Helical Conformation in Domain 3a of Munc18-1 Provides a Template for SNARE (SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Complex Assembly

(2014) Daniel Parisotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter release

(2014) Özgür Genç et al.   eLife

Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion

(2014) Michael Zick et al.   eLife

A distinct tethering step is vital for vacuole membrane fusion

(2014) Michael Zick et al.   eLife

Common intermediates and kinetics, but different energetics, in the assembly of SNARE proteins

(2014) Sylvain Zorman et al.   eLife

Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms

(2014) Ying Lai et al.   eLife

Re-examining how complexin inhibits neurotransmitter release

(2014) Thorsten Trimbuch et al.   eLife

SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18

(2014) Braden T Lobingier et al.   eLife

Studying protein-reconstituted proteoliposome fusion with content indicators in vitro

(2013) Jiajie Diao et al.   BIOESSAYS

Complexin-1 Enhances the On-Rate of Vesicle Docking via Simultaneous SNARE and Membrane Interactions

(2013) Jiajie Diao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The tethering complex HOPS catalyzes assembly of the soluble SNARE Vam7 into fusogenic trans-SNARE complexes

(2013) Michael Zick et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment

(2013) Alf Honigmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation

(2013) K. N. Colbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ

(2013) A. Pertsinidis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

(2012) Josep Rizo et al.   Annual Review of Cell and Developmental Biology

Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission

(2012) Marieke Meijer et al.   EMBO JOURNAL

Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs

(2012) Jae-Yeol Kim et al.   EMBO JOURNAL

Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion

(2012) Peng Zhou et al.   EMBO JOURNAL

PKC-2 Phosphorylation of UNC-18 Ser322 in AFD Neurons Regulates Temperature Dependency of Locomotion

(2012) M. R. Edwards et al.   JOURNAL OF NEUROSCIENCE

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

A single vesicle-vesicle fusion assay for in vitro studies of SNAREs and accessory proteins

(2012) Jiajie Diao et al.   Nature Protocols

Studying calcium-triggered vesicle fusion in a single vesicle-vesicle content and lipid-mixing system

(2012) Minjoung Kyoung et al.   Nature Protocols

Cis- and trans-membrane interactions of synaptotagmin-1

(2012) W. Vennekate et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages

(2012) Y. Gao et al.   SCIENCE

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

(2012) Jiajie Diao et al.   eLife

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

(2011) Cong Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complexin cross-links prefusion SNAREs into a zigzag array

(2011) Daniel Kümmel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state

(2011) Feng Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release

(2011) M. Kyoung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A lipid-anchored SNARE supports membrane fusion

(2011) H. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Vesicle Fusion Assay Reveals Munc18-1 Binding to the SNARE Core Is Sufficient for Stimulating Membrane Fusion

(2010) Jiajie Diao et al.   ACS Chemical Neuroscience

Binding of Munc18-1 to Synaptobrevin and to the SNARE Four-Helix Bundle

(2010) Yi Xu et al.   BIOCHEMISTRY

At the junction of SNARE and SM protein function

(2010) Chavela M Carr et al.   CURRENT OPINION IN CELL BIOLOGY

Single-molecule FRET–derived model of the synaptotagmin 1–SNARE fusion complex

(2010) Ucheor B Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex

(2010) S. S. Rathore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

(2009) Heidi de Wit et al.   CELL

Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components

(2009) C. Stroupe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discrimination between docking and fusion of liposomes reconstituted with neuronal SNARE-proteins using FCS

(2009) A. Cypionka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide

(2008) Pawel Burkhardt et al.   EMBO JOURNAL

NMR analysis of the closed conformation of syntaxin-1

(2008) Xiaocheng Chen et al.   JOURNAL OF BIOMOLECULAR NMR

Munc18a Scaffolds SNARE Assembly to Promote Membrane Fusion

(2008) Travis L. Rodkey et al.   MOLECULAR BIOLOGY OF THE CELL

Construction and use of new cloning vectors for the rapid isolation of recombinant proteins from Escherichia coli

(2008) C.J. Rocco et al.   PLASMID

Accessory Proteins Stabilize the Acceptor Complex for Synaptobrevin, the 1:1 Syntaxin/SNAP-25 Complex

(2008) Keith Weninger et al.   STRUCTURE

Munc-18-1 Regulates the Initial Release Rate of Exocytosis

(2007) Jeff W. Barclay   BIOPHYSICAL JOURNAL