Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling

Targeting Ferroptosis against Ischemia/Reperfusion Cardiac Injury

(2021) José Lillo-Moya et al.   Antioxidants

The Antitumor Effects of Britanin on Hepatocellular Carcinoma Cells and its Real-time Evaluation by In Vivo Bioluminescence Imaging

(2020) Hanrui Li et al.   Anti-Cancer Agents in Medicinal Chemistry

In vivo antitumour activity of Britanin against gastric cancer through nuclear factor‐κB‐mediated immune response

(2020) Keru Shi et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

A novel natural product, britanin, inhibits tumor growth of pancreatic cancer by suppressing nuclear factor-κB activation

(2020) Ke Li et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1

(2020) Hui Dong et al.   Aging-US

Regulation of GSK3β/Nrf2 signaling pathway modulated erastin-induced ferroptosis in breast cancer

(2020) Xinghan Wu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways

(2020) Qi Zeng et al.   PLANTA MEDICA

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

(2019) Toshitaka Nakamura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

(2019) Tae-Jun Park et al.   Cell Death & Disease

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

(2018) Meng-Yu Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pathological Roles of Iron in Cardiovascular Disease

(2018) Motoi Kobayashi et al.   CURRENT DRUG TARGETS

AMP-activated protein kinase sparks the fire of cardioprotection against myocardial ischemia and cardiac ageing

(2018) Chunhu Gu et al.   AGEING RESEARCH REVIEWS

Nrf2, the Master Regulator of Anti-Oxidative Responses

(2017) Sandra Vomund et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway

(2017) Jialin Duan et al.   Scientific Reports

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

(2017) Hongming Lv et al.   Redox Biology

Dissecting the role of AMP-activated protein kinase in human diseases

(2017) Jin Li et al.   Acta Pharmaceutica Sinica B

Britanin attenuates ovalbumin-induced airway inflammation in a murine asthma model

(2016) Sun-Gun Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Haidong Wang et al.   LANCET

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Inulasesquiterpenoids: structural diversity, cytotoxicity and anti-tumor activity

(2014) Guo-Wei Wang et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS