Cathepsin S Cleaves BAX as a Novel and Therapeutically Important Regulatory Mechanism for Apoptosis

Paclitaxel induces apoptosis through the TAK1–JNK activation pathway

(2020) Di Yu‐Wei et al.   FEBS Open Bio

Making Connections: p53 and the Cathepsin Proteases as Co-Regulators of Cancer and Apoptosis

(2020) Surinder M. Soond et al.   Cancers

Graphene Oxide-Based Targeting of Extracellular Cathepsin D and Cathepsin L As A Novel Anti-Metastatic Enzyme Cancer Therapy

(2019) Tanveer Tabish et al.   Cancers

A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif

(2019) Johana C. Misas Villamil et al.   Nature Communications

‘Patchiness’ and basic cancer research: unravelling the proteases

(2019) Surinder M Soond et al.   CELL CYCLE

Cathepsin L-induced galectin-1 may act as a proangiogenic factor in the metastasis of high-grade serous carcinoma

(2019) Md Zahidul I. Pranjol et al.   Journal of Translational Medicine

Targeting BAX to drug death directly

(2019) Loren D. Walensky   Nature Chemical Biology

Lost or Forgotten: The nuclear cathepsin protein isoforms in cancer

(2019) Surinder M. Soond et al.   CANCER LETTERS

The Rich World of p53 DNA Binding Targets: The Role of DNA Structure

(2019) Václav Brázda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reversal of drug resistance by planetary ball milled (PBM) nanoparticle loaded with resveratrol and docetaxel in prostate cancer

(2018) Santosh Kumar Singh et al.   CANCER LETTERS

Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation

(2018) SeoYoung Kim et al.   CELL DEATH AND DIFFERENTIATION

Bax, Bak and beyond - mitochondrial performance in apoptosis

(2017) Aida Peña-Blanco et al.   FEBS Journal

Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage

(2015) Qing-qing Zhang et al.   ACTA PHARMACOLOGICA SINICA

The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update

(2015) Waseem Ahmad Siddiqui et al.   ARCHIVES OF TOXICOLOGY

Cathepsin S: therapeutic, diagnostic, and prognostic potential

(2015) Richard D.A. Wilkinson et al.   BIOLOGICAL CHEMISTRY

Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin

(2015) Zuzanna Baranski et al.   Oncotarget

The effect of catalase on migration and invasion of lung cancer cells by regulating the activities of cathepsin S, L, and K

(2014) Ju-Ying Tsai et al.   EXPERIMENTAL CELL RESEARCH

Conformational Rearrangements in the Pro-apoptotic Protein, Bax, as It Inserts into Mitochondria

(2014) Robert F. Gahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Relevance of Increased Endothelial and Mesothelial Expression of Proangiogenic Proteases and VEGFA in the Omentum of Patients with Metastatic Ovarian High-Grade Serous Carcinoma

(2014) Boleslaw K. Winiarski et al.   Translational Oncology

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Apoptosis induced by paclitaxel via Bcl-2, Bax and caspases 3 and 9 activation in NB4 human leukaemia cells is not modulated by ERK inhibition

(2013) Daniel Morales-Cano et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL

(2012) Hui Tian et al.   CANCER LETTERS

Cathepsin D Primes Caspase-8 Activation by Multiple Intra-chain Proteolysis

(2012) Sébastien Conus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PROSPER: An Integrated Feature-Based Tool for Predicting Protease Substrate Cleavage Sites

(2012) Jiangning Song et al.   PLoS One

The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

(2012) B. N. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT

(2011) S M Soond et al.   ONCOGENE

Wild type p53-dependent transcriptional upregulation of cathepsin L expression is mediated by C/EBPα in human glioblastoma cells

(2010) Rahul Katara et al.   BIOLOGICAL CHEMISTRY

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

Cysteine 62 of Bax Is Critical for Its Conformational Activation and Its Proapoptotic Activity in Response to H2O2-induced Apoptosis

(2008) Chunlai Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

(2008) Gabriela Droga-Mazovec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation

(2008) Avigail D. Amsel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA