Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT

Antibody structure determination using a combination of homology modeling, energy-based refinement, and loop prediction

(2014) Kai Zhu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

A Nanobody-Based System Using Fluorescent Proteins as Scaffolds for Cell-Specific Gene Manipulation

(2013) Jonathan C.Y. Tang et al.   CELL

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Long-Term Follow-Up of Colonoscopic Fecal Microbiota Transplant for Recurrent Clostridium difficile Infection

(2012) Lawrence J Brandt et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection

(2012) Irina L. Tutykhina et al.   ANTIVIRAL RESEARCH

Endocytosis of soluble immune complexes leads to their clearance by Fc RIIIB but induces neutrophil extracellular traps via Fc RIIA in vivo

(2012) K. Chen et al.   BLOOD

Case fatality associated with a hypervirulent strain in patients with culture-positive Clostridium difficile infection: a retrospective population-based study

(2012) Reetta Huttunen et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Predicting Recurrence of C. difficile Colitis Using Bacterial Virulence Factors: Binary Toxin Is the Key

(2012) David B. Stewart et al.   JOURNAL OF GASTROINTESTINAL SURGERY

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

(2012) Florian Klein et al.   NATURE

Clostridium difficile binary toxin (CDT) and diarrhea

(2011) Robert J. Carman et al.   ANAEROBE

Super toxins from a super bug: structure and function ofClostridium difficiletoxins

(2011) Abigail H. Davies et al.   BIOCHEMICAL JOURNAL

In situ gastrointestinal protection against anthrax edema toxin by single-chain antibody fragment producing lactobacilli

(2011) Kasper Andersen et al.   BMC BIOTECHNOLOGY

Cholesterol- and Sphingolipid-rich Microdomains Are Essential for Microtubule-based Membrane Protrusions Induced byClostridium difficileTransferase (CDT)

(2011) Carsten Schwan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutralization ofClostridium difficileToxin A with Single-domain Antibodies Targeting the Cell Receptor Binding Domain

(2011) Greg Hussack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered Single-Domain Antibodies with High Protease Resistance and Thermal Stability

(2011) Greg Hussack et al.   PLoS One

Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)

(2011) P. Papatheodorou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Best Strategies in Recurrent or Persistent Clostridium difficile Infection

(2011) Christine S. Cocanour   Surgical Infections

Clostridial Binary Toxins: Iota and C2 Family Portraits

(2011) Bradley G. Stiles et al.   Frontiers in Cellular and Infection Microbiology

Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium

(2010) Vanina Alzogaray et al.   FASEB JOURNAL

Nanoparticle-based therapeutic delivery of prohibitin to the colonic epithelial cells ameliorates acute murine colitis

(2010) Arianne L. Theiss et al.   INFLAMMATORY BOWEL DISEASES

The emergence of ‘hypervirulence’ in Clostridium difficile

(2010) Stephen T. Cartman et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Relatedness of Human and Animal Clostridium difficile PCR Ribotype 078 Isolates Determined on the Basis of Multilocus Variable-Number Tandem-Repeat Analysis and Tetracycline Resistance

(2010) D. Bakker et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Therapeutic transplantation of the distal gut microbiota

(2010) A Khoruts et al.   Mucosal Immunology

The role of toxin A and toxin B in Clostridium difficile infection

(2010) Sarah A. Kuehne et al.   NATURE

Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers

(2010) Geoffrey K Feld et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Clostridium difficile— Beyond Antibiotics

(2010) Lorraine Kyne   NEW ENGLAND JOURNAL OF MEDICINE

Treatment with Monoclonal Antibodies againstClostridium difficileToxins

(2010) Israel Lowy et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Versatile MHC Class I-related FcRn Protects IgG and Albumin from Degradation: Implications for Development of New Diagnostics and Therapeutics

(2009) Jan Terje Andersen et al.   Drug Metabolism and Pharmacokinetics

Drug-Loaded Nanoparticles Targeted to the Colon With Polysaccharide Hydrogel Reduce Colitis in a Mouse Model

(2009) Hamed Laroui et al.   GASTROENTEROLOGY

Structural Basis for Substrate Recognition in the Enzymatic Component of ADP-ribosyltransferase Toxin CDTa fromClostridium difficile

(2009) Amit Sundriyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

(2009) Janusz Wesolowski et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis

(2009) K Vandenbroucke et al.   Mucosal Immunology

Toxin B is essential for virulence of Clostridium difficile

(2009) Dena Lyras et al.   NATURE

Clostridium difficile infection: new developments in epidemiology and pathogenesis

(2009) Maja Rupnik et al.   NATURE REVIEWS MICROBIOLOGY

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Clostridium difficile Toxin CDT Induces Formation of Microtubule-Based Protrusions and Increases Adherence of Bacteria

(2009) Carsten Schwan et al.   PLoS Pathogens

Binary Actin-ADP-Ribosylating Toxins and their Use as Molecular Trojan Horses for Drug Delivery into Eukaryotic Cells

(2008) Holger Barth et al.   CURRENT MEDICINAL CHEMISTRY

Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology

(2008) B. M. Tijink et al.   MOLECULAR CANCER THERAPEUTICS

Clostridium difficile— More Difficult Than Ever

(2008) Ciarán P. Kelly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens  -toxin

(2008) H. Tsuge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA