Iron, oxygen, and the pulmonary circulation

Iron Homeostasis and Pulmonary Hypertension: Iron Deficiency Leads to Pulmonary Vascular Remodeling in the Rat

(2015) E. Cotroneo et al.   CIRCULATION RESEARCH

Changes in Echocardiographic Parameters in Iron Deficiency Patients with Heart Failure and Chronic Kidney Disease Treated with Intravenous Iron

(2015) Jorge E. Toblli et al.   Heart Lung and Circulation

Inhaled nitric oxide alters the distribution of blood flow in the healthy human lung, suggesting active hypoxic pulmonary vasoconstriction in normoxia

(2015) Amran K. Asadi et al.   JOURNAL OF APPLIED PHYSIOLOGY

Increased hepcidin levels in high-altitude pulmonary edema

(2015) Sandro Altamura et al.   JOURNAL OF APPLIED PHYSIOLOGY

Adaptation of iron requirement to hypoxic conditions at high altitude

(2015) Max Gassmann et al.   JOURNAL OF APPLIED PHYSIOLOGY

Determinants of ventilation and pulmonary artery pressure during early acclimatization to hypoxia in humans

(2015) Marzieh Fatemian et al.   JOURNAL OF PHYSIOLOGY-LONDON

Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency

(2014) P. Ponikowski et al.   EUROPEAN HEART JOURNAL

Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure

(2014) E. A. Jankowska et al.   EUROPEAN HEART JOURNAL

Ferric carboxymaltose improves exercise capacity and quality of life in patients with pulmonary arterial hypertension and iron deficiency: A pilot study

(2014) Thomas Viethen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Identification of erythroferrone as an erythroid regulator of iron metabolism

(2014) Léon Kautz et al.   NATURE GENETICS

A genetic mechanism for Tibetan high-altitude adaptation

(2014) Felipe R Lorenzo et al.   NATURE GENETICS

Anemia and iron deficiency in COPD patients: prevalence and the effects of correction of the anemia with erythropoiesis stimulating agents and intravenous iron

(2014) Donald S Silverberg et al.   BMC Pulmonary Medicine

Clinical Demonstration of Efficiency and Reversibility of Hypoxic Pulmonary Vasoconstriction in a Patient Presenting with Unilateral Incomplete Bronchial Occlusion

(2014) Syeda Jafri et al.   Pulmonary Circulation

Supplementation of Iron in Pulmonary Hypertension: Rationale and Design of a Phase II Clinical Trial in Idiopathic Pulmonary Arterial Hypertension

(2014) Luke S.G.E. Howard et al.   Pulmonary Circulation

Iron deficiency in chronic heart failure: An international pooled analysis

(2013) IJsbrand T. Klip et al.   AMERICAN HEART JOURNAL

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2  mRNA translation

(2013) N. Wilkinson et al.   BLOOD

Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing

(2013) Xu Zhang et al.   BLOOD CELLS MOLECULES AND DISEASES

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

(2013) Manik C. Ghosh et al.   Cell Metabolism

The transforming growth factor-β-bone morphogenetic protein type signalling pathway in pulmonary vascular homeostasis and disease

(2013) Paul D. Upton et al.   EXPERIMENTAL PHYSIOLOGY

Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers

(2013) Oliver Goetze et al.   HEPATOLOGY

The clinical significance of anaemia and disturbed iron homeostasis in chronic respiratory failure

(2013) R. Schneckenpointner et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia

(2013) Nayia Petousi et al.   JOURNAL OF APPLIED PHYSIOLOGY

Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era

(2013) Nayia Petousi et al.   JOURNAL OF APPLIED PHYSIOLOGY

HIF and pulmonary vascular responses to hypoxia

(2013) Larissa A. Shimoda et al.   JOURNAL OF APPLIED PHYSIOLOGY

Erythrocytosis and Pulmonary Hypertension in a Mouse Model of HumanHIF2AGain of Function Mutation

(2013) Qiulin Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2

(2013) Tammie Bishop et al.   JOURNAL OF PHYSIOLOGY-LONDON

Genetic Evidence of Paleolithic Colonization and Neolithic Expansion of Modern Humans on the Tibetan Plateau

(2013) Xuebin Qi et al.   MOLECULAR BIOLOGY AND EVOLUTION

Variations in Alveolar Partial Pressure for Carbon Dioxide and Oxygen Have Additive Not Synergistic Acute Effects on Human Pulmonary Vasoconstriction

(2013) Quentin P. P. Croft et al.   PLoS One

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Point: Counterpoint: Hypobaric hypoxia induces/does not induce different responses from normobaric hypoxia

(2012) Grégoire P. Millet et al.   JOURNAL OF APPLIED PHYSIOLOGY

Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis

(2012) Qingdu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxic Pulmonary Vasoconstriction

(2012) J. T. Sylvester et al.   PHYSIOLOGICAL REVIEWS

The HIF Pathway and Erythrocytosis

(2011) Frank S. Lee et al.   Annual Review of Pathology-Mechanisms of Disease

The long history of iron in the Universe and in health and disease

(2011) Alex D. Sheftel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Regulation of hepcidin expression at high altitude

(2011) N. P. Talbot et al.   BLOOD

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation

(2011) Federico Formenti et al.   FASEB JOURNAL

Intravenous Iron Supplementation May Protect Against Acute Mountain Sickness: A Randomized, Double-Blinded, Placebo-Controlled Trial

(2011) Nick P. Talbot et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Peopling the Tibetan Plateau: Insights from Archaeology

(2011) Mark Aldenderfer   HIGH ALTITUDE MEDICINE & BIOLOGY

Iron Deficiency and Raised Hepcidin in Idiopathic Pulmonary Arterial Hypertension

(2011) Christopher J. Rhodes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension

(2011) E. Soon et al.   THORAX

The human side of hypoxia-inducible factor

(2010) Thomas G. Smith et al.   BRITISH JOURNAL OF HAEMATOLOGY

Iron deficiency is common in idiopathic pulmonary arterial hypertension

(2010) G. Ruiter et al.   EUROPEAN RESPIRATORY JOURNAL

Extent to which pulmonary vascular responses to Pco2 and Po2 play a functional role within the healthy human lung

(2010) Keith L. Dorrington et al.   JOURNAL OF APPLIED PHYSIOLOGY

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

(2010) W. M. Bernhardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Natural selection on EPAS1 (HIF2 ) associated with low hemoglobin concentration in Tibetan highlanders

(2010) C. M. Beall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Evidence for High-Altitude Adaptation in Tibet

(2010) T. S. Simonson et al.   SCIENCE

Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

(2010) X. Yi et al.   SCIENCE

Therapeutic Manipulation of the HIF Hydroxylases

(2009) Simon Nagel et al.   ANTIOXIDANTS & REDOX SIGNALING

Iron Homeostasis and Its Interaction with Prolyl Hydroxylases

(2009) David R. Mole   ANTIOXIDANTS & REDOX SIGNALING

Age-Associated Increases in Pulmonary Artery Systolic Pressure in the General Population

(2009) Carolyn S.P. Lam et al.   CIRCULATION

Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension

(2009) Thomas G. Smith et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency

(2009) Stefan D. Anker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Iron Sequestration and Anemia of Inflammation

(2009) Tomas Ganz et al.   SEMINARS IN HEMATOLOGY

Hypoxic pulmonary vasoconstriction does not contribute to pulmonary blood flow heterogeneity in normoxia in normal supine humans

(2008) T. J. Arai et al.   JOURNAL OF APPLIED PHYSIOLOGY

The increase in pulmonary arterial pressure caused by hypoxia depends on iron status

(2008) Thomas G. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Expanding chemical biology of 2-oxoglutarate oxygenases

(2008) Christoph Loenarz et al.   Nature Chemical Biology