HIF and pulmonary vascular responses to hypoxia

Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1

(2013) Sarah Pisarcik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The role of hypoxia in pulmonary vascular diseases: a perspective

(2013) Norbert F. Voelkel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia-Induced Inflammation in the Lung

(2013) Stephen Fröhlich et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hypoxia-Inducible Factor-1α in Pulmonary Artery Smooth Muscle Cells Lowers Vascular Tone by Decreasing Myosin Light Chain Phosphorylation

(2013) Yu-Mee Kim et al.   CIRCULATION RESEARCH

mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects

(2013) Elena A. Goncharova   FASEB JOURNAL

Erythrocytosis and Pulmonary Hypertension in a Mouse Model of HumanHIF2AGain of Function Mutation

(2013) Qiulin Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular remodeling in pulmonary hypertension

(2013) Larissa A. Shimoda et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1

(2012) Kyle Leggett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Reversal of pulmonary vascular remodeling in pulmonary hypertensive rats

(2012) Ilona Sluiter et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally

(2012) Edwina Cahill et al.   EXPERIMENTAL PHYSIOLOGY

Endothelin-1 induces hypoxia inducible factor 1α expression in pulmonary artery smooth muscle cells

(2012) Manxiang Li et al.   FEBS LETTERS

55th Bowditch Lecture: Effects of chronic hypoxia on the pulmonary circulation: Role of HIF-1

(2012) Larissa A. Shimoda   JOURNAL OF APPLIED PHYSIOLOGY

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

(2012) Carmen Chak-Lui Wong et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxic Pulmonary Vasoconstriction

(2012) J. T. Sylvester et al.   PHYSIOLOGICAL REVIEWS

Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2

(2012) Nanduri R. Prabhakar et al.   PHYSIOLOGICAL REVIEWS

Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning

(2012) K. Sarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Digoxin inhibits development of hypoxic pulmonary hypertension in mice

(2012) E. M. Abud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silencing of Sodium–Hydrogen Exchanger 1 Attenuates the Proliferation, Hypertrophy, and Migration of Pulmonary Artery Smooth Muscle Cells via E2F1

(2011) Lunyin Yu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation

(2011) Federico Formenti et al.   FASEB JOURNAL

Hypoxia: Adapting to High Altitude by Mutating EPAS-1, the Gene Encoding HIF-2α

(2011) Martha C. Tissot van Patot et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells

(2010) Iwona Fijalkowska et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

(2010) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Digoxin inhibits retinal ischemia-induced HIF-1α expression and ocular neovascularization

(2010) Tsunehiko Yoshida et al.   FASEB JOURNAL

The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice

(2010) Michele M. Hickey et al.   JOURNAL OF CLINICAL INVESTIGATION

Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment

(2009) Danielle L. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Intermittent Hypoxia-Mediated Plasticity of Acute O2 Sensing Requires Altered Red-Ox Regulation by HIF-1 and HIF-2

(2009) Nanduri R. Prabhakar et al.   Annals of the New York Academy of Sciences

Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis

(2009) G. L. Semenza   BLOOD

Endothelial deletion of hypoxia-inducible factor-2  (HIF-2 ) alters vascular function and tumor angiogenesis

(2009) N. Skuli et al.   BLOOD

Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension

(2009) Thomas G. Smith et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

(2009) William Y. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Updated Clinical Classification of Pulmonary Hypertension

(2009) Gérald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

(2009) Gregg L. Semenza   PHYSIOLOGY

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficiency of the NHE1 Gene Prevents Hypoxia-induced Pulmonary Hypertension and Vascular Remodeling

(2008) Lunyin Yu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2  mutation

(2008) D. P. Gale et al.   BLOOD

Nuclear Oxygen Sensing: Induction of Endogenous Prolyl-hydroxylase 2 Activity by Hypoxia and Nitric Oxide

(2008) Utta Berchner-Pfannschmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-dependent impairment of HIF-1α expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells

(2008) Lixin Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The increase in pulmonary arterial pressure caused by hypoxia depends on iron status

(2008) Thomas G. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1α-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer

(2007) Stephen L. Archer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes

(2007) E. Miles Whitman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY