Article
Chemistry, Medicinal
Liping Wang, Yiwen Hou, Rong Wang, Qi Pan, Debao Li, Han Yan, Zuyue Sun
Summary: This study found that astaxanthin (AST) may have an inhibitory effect on testosterone-induced benign prostatic hyperplasia in rats by regulating superoxide dismutase (SOD) activity and testosterone (T) and dihydrotestosterone (DHT) levels.
Article
Medicine, Research & Experimental
Haifa Almukadi, Basma G. Eid, Rasheed A. Shaik, Ashraf B. Abdel-Naim, Ahmed Esmat
Summary: Auraptene-NLC demonstrates protective effects against BPH in rats induced by testosterone, through its anti-inflammatory, antioxidant, and proapoptotic activities, as well as PPAR family activation. The drug alleviates prostatic hyperplasia and oxidative stress, improves prostate tissue structure, and regulates the expression of apoptosis and inflammatory factors.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Plant Sciences
Lenah S. Binmahfouz, Haifa Almukadi, Abdulmohsin J. Alamoudi, Ali M. El-Halawany, Hossam M. Abdallah, Mardi M. Algandaby, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Faraj A. Alghamdi, Majed Al-Shaeri, Ashraf B. Abdel-Naim
Summary: The study found that 6-PD could inhibit testosterone-induced BPH in rats and has anti-proliferative, antioxidant, and anti-inflammatory properties, as well as the ability to inhibit activation of the AKT/mTOR axis.
Article
Pharmacology & Pharmacy
Abdulmohsin J. Alamoudi, Sami A. Alessi, Waleed Y. Rizg, Abdulmajeed M. Jali, Awaji Y. Safhi, Fahad Y. Sabei, Sameer Alshehri, Khaled M. Hosny, Ashraf B. Abdel-Naim
Summary: This study found that cordycepin has the ability to prevent testosterone-induced benign prostatic hyperplasia (BPH) in rats. It exerts its effects through its antiproliferative, antioxidant, anti-inflammatory, pro-apoptotic actions, and modulation of AMPK and AKT activation.
Article
Plant Sciences
Thuy Doan Minh, Tuan Nguyen Thanh Ha, Thuan Nguyen Duy, Ngan Nguyen Hoang, Dung PhamTien, Hung Pham Thai, Hoa Nguyen Thi, Phuong Dang Thi Lan, Binh Pham Quoc, D. Y. Ivkin, M. N. Povydysh, Bang Nguyen Cong, M. V. Krasnova
Summary: LPKTT capsules inhibit prostate proliferation in rats induced by testosterone propionate, reducing micturition frequency, increasing voided volume, and showing similar effects to positive controls in terms of reducing prostate weight and the ratio of prostate weight to body weight.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nyera H. El-Shafei, Mai A. Zaafan, Esraa A. Kandil, Rabab H. Sayed
Summary: Benign prostatic hyperplasia (BPH) is a non-malignant enlargement of prostate cells that causes lower urinary tract symptoms. The pathogenesis of BPH involves various factors such as androgens receptors signaling pathways, oxidative stress, apoptosis, and potential changes in IGF-1/PI3K/AKT/FOXO pathway. This study investigates the potential beneficial effects of simvastatin on testosterone-induced BPH.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Liang Pan, Shiyu Su, Yuanyuan Li, Di Liu, Lingyu Shen, Haiying Wang, Jiayu Wen, Hui Hu, Ruwen Zheng
Summary: The effects of acupuncture and finasteride on the expression of oestrogen receptors (ERs) alpha and beta in testosterone-induced benign prostatic hyperplasia (BPH) in rats were investigated. The results showed that both acupuncture and finasteride significantly improved the distribution of ERs and could improve BPH. Additionally, ER beta mRNA expression in the finasteride group was significantly different compared to the control and acupuncture groups, suggesting a potential mechanism of action for the treatment of BPH.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Urology & Nephrology
Stephen J. Summers, Joseph M. Armstrong, Steven A. Kaplan, Alex E. Te, Alvin Le, Scott M. Heiner, Angela P. Presson, Guo Wei, James M. Hotaling
Summary: This study analyzed 19,824 voiding profiles using a home uroflow device, revealing significant variability in individual voiding parameters throughout the day and worsening with age. Multiple measurements at home provide a more realistic assessment of true voiding behavior, helping urologists make better decisions in patient care.
JOURNAL OF UROLOGY
(2021)
Article
Biology
Chao Yu Hsu, Yi Sheng Lin, Wei Chun Weng, Lauren Panny, Hsiang Lai Chen, Min Che Tung, Yen Chuan Ou, Chi Chien Lin, Che Hsueh Yang
Summary: The study demonstrates that phloretin at a dose of 100 mg/kg/day can effectively reduce prostate enlargement induced by testosterone in rats by reducing inflammation, oxidative stress, and promoting apoptosis.
Article
Medicine, General & Internal
Yu Fan, Tu-Run Song, Qiang Wei, Lu Yang, Tao Lin, Xiao-Bing Feng, Xian-Ding Wang, Zhong-Li Huang, Shi-Jian Feng
Summary: Estrogen plays a role in the development of benign prostatic hyperplasia (BPH) through promoting AQP5 expression and subsequent epithelial-mesenchymal transition (EMT) in prostate cells. This study found that BPH tissues had higher AQP5 expression and EMT levels compared to normal prostate tissues. Estrogen-stimulated cells had increased AQP5 expression, cell proliferation, and EMT, which could be partially reversed by AQP5 knockdown.
CHINESE MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Glaucia Mara MenezesdaSilva, Eduardo Carvalho de Arruda Veiga, Manuel Jesus Simoes, Ricardo Santos Simoes, Marcos Eiji Shiroma, Maria Candida Pinheiro Baracat, Givanna Santos Cavalcanti, Jose Maria Soares Junior, Edmund Chada Baracat
Summary: This study aimed to evaluate the effects of estrogen and raloxifene on the synaptic density profile in the CA1 region of the hippocampus in ovariectomized rats. The results showed a significant increase in the synaptic density profile in the estrogen and raloxifene treatment groups compared to the control groups, suggesting their important role in hippocampal learning and memory.
Article
Medicine, General & Internal
Lu-Yao Li, Jie Han, Lan Wu, Cheng Fang, Wei-Guang Li, Jia-Min Gu, Tong Deng, Chang-Jiang Qin, Jia-Yan Nie, Xian-Tao Zeng
Summary: The study investigates the regulation of benign prostatic hyperplasia (BPH) on gut microbiota composition and metabonomics. The results show an association between gut microbiota and BPH, but the causal relationship between the two is unclear. Further studies are needed to elucidate the potential mechanisms and causal relationships between BPH and gut microbiota.
MILITARY MEDICAL RESEARCH
(2022)
Article
Food Science & Technology
Yun-Soo Seo, Na-Rea Shin, Hyeon Hwa Nam, Jun-Ho Song, Byeong Cheol Moon, Goya Choi, In-Sik Shin, Joong-Sun Kim
Summary: The study found that P. brevitarsis significantly inhibits prostate hyperplasia in BPH animals, reduces dihydrotestosterone levels, and effectively reduces testosterone-induced prostatic epithelial cell hyperplasia.
FOOD SCIENCE & NUTRITION
(2021)
Article
Endocrinology & Metabolism
Edmund Charles Jenkins, Gabriella Casalena, Maria Gomez, Dazhi Zhao, Timothy C. Kenny, Nagma Shah, Giovanni Manfredi, Doris Germain
Summary: Dysfunctions in proteasome and protein aggregation are key features of several neurodegenerative disorders. The study found distinct effects of different selective estrogen receptor modulators (SERMs) on gene expression in the spinal cord, with raloxifene showing significant regulation of deubiquitinating enzymes, proteasome subunits and assembly factors. In a mouse model of amyotrophic lateral sclerosis, even a low dose of raloxifene reduced mutant SOD1 aggregates in females and delayed muscle strength decline. These results highlight the importance of considering sex-specific and SERM-selective effects in clinical trials for neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Kai-Yen Tsai, Deng-Chyang Wu, Wen-Jeng Wu, Jiunn-Wei Wang, Yung-Shun Juan, Ching-Chia Li, Chung-Jung Liu, Hsiang-Ying Lee
Summary: This study investigates the potential relationship between human microbiota and prostatic disease by analyzing stool and urine samples from patients. The results suggest that the microbiota composition in urine samples is different among different patient populations, indicating a potential link between microbiota and prostatic disease.
Article
Chemistry, Applied
Jie Du, Chun-Hua Wang, Jing Yang, Xin He, Xiao-Liang Han, Cong-Cong Li, Xin Chai, Yue-Fei Wang, Yan Zhu, Zheng Li
NATURAL PRODUCT RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Shijie Cao, Yiyuan Huang, Qiang Zhang, Fangjin Lu, Paul Owusu Donkor, Yan Zhu, Feng Qiu, Ning Kang
Article
Cardiac & Cardiovascular Systems
Jing Ma, Dan Zhao, Xiaolin Wang, Chuanrui Ma, Ke Feng, Shuang Zhang, Yuanli Chen, Yan Zhu, Xiumei Gao, Buchang Zhao, Yong Wang, Ke Qian, Xiaoju Li, Yajun Duan, Jihong Han, Xiaoxiao Yang
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2019)
Article
Plant Sciences
Jinqiang Zhu, Qiaofeng Ye, Shixin Xu, Yan-xu Chang, Xuan Liu, Yan Ma, Yan Zhu, Shengyu Hua
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Wei Xiang, Guo-Dong Zhang, Fang-Yi Li, Teng-long Wang, Tong-Chuan Suo, Chun-Hua Wang, Zheng Li, Yan Zhu
JOURNAL OF CHEMISTRY
(2019)
Review
Pharmacology & Pharmacy
Jihong Han, Hao Tan, Yajun Duan, Yuanli Chen, Yan Zhu, Buchang Zhao, Yong Wang, Xiaxiao Yang
PHARMACOLOGICAL RESEARCH
(2019)
Article
Pharmacology & Pharmacy
Taiyi Wang, Weiwei Xie, Jiahui Yu, Clive Ellory, Robert Wilkins, Yan Zhu, Yu-ling Ma
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Plant Sciences
Jiahui Yu, Yuhong Li, Xinyan Liu, Zhe Ma, Sarhene Michael, John O. Orgah, Guanwei Fan, Yan Zhu
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Qi Li, Yi Chen, Dan Zhao, Shu Yang, Shuang Zhang, Zhuo Wei, Yong Wang, Ke Qian, Buchang Zhao, Yan Zhu, Yuanli Chen, Yajun Duan, Jihong Han, Xiaoxiao Yang
PHARMACOLOGICAL RESEARCH
(2019)
Article
Integrative & Complementary Medicine
Jingrui Chen, Jing Wei, John Orgah, Yan Zhu, Jingyu Ni, Lingyan Li, Han Zhang, Xiumei Gao, Guanwei Fan
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Review
Integrative & Complementary Medicine
Hongyan Zhu, Xintong Wang, Xiaoming Wang, Guixiang Pan, Yan Zhu, Yuxin Feng
Summary: This study identified the major risk factors leading to adverse reactions to traditional Chinese medicine (TCM), including risks from the herbs and their administration, as well as risks related to human physiology, pathology, and genetics. The study also analyzed the effects of toxic Chinese herbs and discussed common chemical substances, toxic mechanisms, and detoxification methods. Additionally, methodological studies on TCM toxicity were discussed, and a systematic evaluation strategy for toxic Chinese medicines was proposed.
JOURNAL OF HERBAL MEDICINE
(2021)
Article
Plant Sciences
Yuying Wang, Xiaoqing Sang, Rui Shao, Honglin Qin, Xuanhao Chen, Zhifeng Xue, Lin Li, Yu Wang, Yan Zhu, Yanxu Chang, Xiumei Gao, Boli Zhang, Han Zhang, Jian Yang
Summary: Xuanfei Baidu Decoction has protective effects against acute inflammation and pulmonary fibrosis by inhibiting the IL-6/STAT3 signaling pathway to protect against macrophage-induced inflammation and pulmonary fibrosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Zhixiong Li, Guangxu Xiao, Huanyi Wang, Shuang He, Yan Zhu
Summary: The study showed that Shuxuening injection (SXNI) significantly reduced hippocampal neuronal apoptosis in post-stroke mice by inhibiting neuronal apoptosis. SXNI exerted its anti-apoptotic effect by regulating Bax/Bcl2 and blocking Caspase-3 activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Yule Wang, Xinyan Liu, Wen Zhang, Shuang He, Yiqian Zhang, John Orgah, Yi Wang, Yan Zhu
Summary: This study explores the chemical basis and molecular mechanism of the anti-stroke therapy of QSYQ and its components YQ and HX. The results show that YQ and HX components synergistically protect the brain from cerebral ischemia/reperfusion injury by regulating inflammation and autophagy. These findings shed new light on the understanding of the traditional Chinese medicine principle of tonifying Qi and activating blood, particularly in ischemic stroke.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Jin Sun, Qing Yuan, Lichen Guo, Guangxu Xiao, Tong Zhang, Bing Liang, Rongmei Yao, Yan Zhu, Yue Li, Limin Hu
Summary: This study found that exosomes derived from brain endothelial cells (EC-Exo) can protect neurons by inhibiting apoptosis and promoting synaptic remodeling in the brain.