Article
Medicine, General & Internal
Nili Schamroth Pravda, Mark Kheifets, Maya Wiessman, Dorit Leshem-Lev, Hana Vaknin Assa, Ran Kornowski, Yeela Talmor-Barkan, Leor Perl
Summary: This study found that higher levels of reticulated platelets at baseline are significantly correlated with a more potent endothelial progenitor cell response in patients with ST-elevation myocardial infarction. However, the correlation between reticulated platelet quantity and endothelial progenitor cell markers weakened at 24 hours after primary percutaneous intervention.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Peng-Xin Ge, Ting Tai, Li -Ping Jiang, Jin-Zi Ji, Qiong-Yu Mi, Ting Zhu, Yi-Fei Li, Hong-Guang Xie
Summary: Choline and TMAO impair the metabolic activation of and platelet response to clopidogrel through the activation of the NOX-dependent ROS/Nrf2/CES1 pathway, suggesting novel strategies for overcoming clopidogrel resistance from bench to bedside.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Chemistry, Analytical
Xiaoying Wang, Tao Gao, Jin Zhu, Shipeng Long, Songyan Zhao, Li Yuan, Zhaoxia Wang
Summary: Hematogenous metastasis is the main cause of cancer-related deaths, and platelets play a crucial role in promoting this process. A new channeled and conductive 3D electrode was constructed to capture and detect platelet interacted circulating tumor cells (CTCs). The modified antibody allowed for the capture of platelet-interacted CTC hybrids, while the conductive layer facilitated electron transfer for sensitive electrochemical detection. This work provides an efficient method for simultaneous capture and detection of invasive CTCs, with the potential to monitor hematogenous metastasis accurately.
ANALYTICAL CHEMISTRY
(2023)
Review
Cell Biology
Katharina Neubauer, Barbara Zieger
Summary: Endothelial cells play a crucial role in maintaining blood fluidity and controlled vascular hemostasis, balancing procoagulant and anticoagulant mechanisms. They prevent platelet activation and promote fibrinolytic and antithrombotic properties, while also supporting clot formation at sites of vascular damage.
CELL AND TISSUE RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Bernadeta Chyrchel, Olga Kruszelnicka, Andrzej Surdacki
Summary: This study compared the effects of ticagrelor and clopidogrel on endothelial biomarkers and platelet reactivity in patients with acute coronary syndrome (ACS). The results showed that ticagrelor users had decreased platelet aggregation and soluble P-selectin levels compared to clopidogrel users. In addition, T2DM patients on ticagrelor had lower levels of soluble vascular cell adhesion molecule-1 compared to those on clopidogrel.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marivee Borges-Rodriguez, Corbin A. Shields, Olivia K. Travis, Robert W. Tramel, Cedar H. Baik, Chelsea A. Giachelli, Jan MichaelWilliams, Geilda A. Tardo, Jan Michael Williams, Denise C. Cornelius
Summary: The study suggests that activated platelets may contribute to sepsis-induced renal injury through NLRP3 activation in platelets, indicating platelets could be a therapeutic target for reducing renal injury in septic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Dawn S. Kuszynski, D. Adam Lauver
Summary: Clopidogrel is a commonly used anti-thrombotic drug that acts by inhibiting the receptor on platelets. In addition to its effects on platelets, it may also have non-hemostatic effects on other tissues, possibly mediated by its metabolites.
PURINERGIC SIGNALLING
(2022)
Article
Critical Care Medicine
George A. Alba, Andriy O. Samokhin, Rui-Sheng Wang, Ying-Yi Zhang, Bradley M. Wertheim, Elena Arons, Edward A. Greenfield, Martina H. Lundberg Slingsby, Julia R. Ceglowski, Kathleen J. Haley, Frederick P. Bowman, Yen-Rei Yu, John C. Haney, George Eng, Richard N. Mitchell, Anthony Sheets, Sara O. Vargas, Sachiko Seo, Richard N. Channick, Peter J. Leary, Sudarshan Rajagopal, Joseph Loscalzo, Elisabeth M. Battinelli, Bradley A. Maron
Summary: The study identified the modifiable protein-protein interaction between NEDD9 and P-selectin as a potential target to inhibit platelet-pulmonary endothelial adhesion and thromboembolic vascular remodeling under hypoxia conditions. Custom anti-NEDD9 antibody effectively inhibited platelet adhesion to pulmonary artery endothelial cells and reduced chronic pulmonary thromboembolic remodeling in vivo.Therefore, the NEDD9-P-selectin interaction may have therapeutic implications for patients with disorders characterized by increased hypoxia signaling pathways, such as CTEPH.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Emanuela Marcantoni, Michael S. Garshick, Tamar Schwartz, Nicole Ratnapala, Matthew Cambria, Rebecca Dann, Meagan O'Brien, Adriana Heguy, Jeffrey S. Berger
Summary: Clopidogrel, compared with aspirin and no-treatment, reduces platelet activation and the risk of cardiovascular disease in HIV-positive patients.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Hematology
Lydie Crescence, Roxane Darbousset, Eva Caroff, Francis Hubler, Markus A. Riederer, Laurence Panicot-Dubois, Christophe Dubois
Summary: Through real-time intravital microscopy in mice, it was found that compared to clopidogrel and ticagrelor, Selatogrel has fewer platelet thrombus formations, better stability of hemostatic seals, and does not interfere with endothelial activation, neutrophil function, and fibrin-mediated stabilization of hemostatic seals.
THROMBOSIS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Matheus Henrique Jantsch, Pedro Henrique Doleski, Altevir Rossato Viana, Jean Lucas Gutknecht da Silva, Daniela Ferreira Passos, Fernanda Licker Cabral, Alessandra Guedes Manzoni, Renan da Silva Ebone, Ana Barbara Uchoa Soares, Cinthia Melazzo de Andrade, Maria Rosa Chitolina Schetinger, Daniela Bitencourt Rosa Leal
Summary: Metastatic melanoma, an aggressive skin cancer, can be influenced by platelet activation, which is controlled by P2Y12 receptor and purinergic enzymes. Inhibition of P2Y12 with clopidogrel bisulfate (CB) has shown significant effects in reducing cell viability and proliferation in B16-F10 culture, as well as decreasing tumor nodule counts and lactate dehydrogenase levels, and increasing platelet purine metabolism in a melanoma mouse model. These findings indicate the potential of CB in modulating melanoma progression.
BIOCHEMISTRY AND CELL BIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Alberto Zanetto, Patrick Northup, Lara Roberts, Marco Senzolo
Summary: Hospitalised patients with decompensated cirrhosis experience a rebalanced haemostasis, but this balance can easily be disrupted, leading to bleeding. Acute kidney injury, bacterial infections/sepsis, and progression to acute-on-chronic liver failure further increase the risk of bleeding. Unfortunately, there is no single laboratory method to accurately assess bleeding risk and guide preventive measures. Understanding the haemostatic alterations during acute illness could improve the management of these patients.
JOURNAL OF HEPATOLOGY
(2023)
Review
Cell Biology
Katharina Neubauer, Barbara Zieger
Summary: Septins are conserved cytoskeletal GTP-binding proteins found in almost all eukaryotes except higher plants. In mammals, septins have diverse functions and expression patterns, particularly in endothelial cells and platelets, playing crucial roles in hemostasis and various cellular processes. However, the precise function of septins in the biology of endothelial cells and platelets remains poorly understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Roberto Carnevale, Cristina Nocella, Sonia Schiavon, Vittoria Cammisotto, Maria Cotugno, Maurizio Forte, Valentina Valenti, Simona Marchitti, Daniele Vecchio, Giuseppe Biondi Zoccai, Speranza Rubattu, Ombretta Martinelli, Pasquale Pignatelli, Francesco Violi, Massimo Volpe, Francesco Versaci, Luigi Frati, Giacomo Frati, Sebastiano Sciarretta
Summary: A combination of natural activators of autophagy was found to reduce platelet activity and oxidative stress, and improve endothelial cell survival and function in individuals at high cardiovascular risk.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Natalia Marcinczyk, Anna Gromotowicz-Poplawska, Michal Tomczyk, Ewa Chabielska
Summary: This paper describes the hemostasis-modifying ability of tannins, compounds of plant origin and plant extracts, and their influence on the thrombotic process. It highlights the effects of tannins on platelets, coagulation system, fibrinolysis system, and endothelium, as well as their pathophysiology-dependent action. The low bioavailability of tannins suggests the need for further in vivo studies to understand their actual activity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Integrative & Complementary Medicine
Hongyan Zhu, Xintong Wang, Xiaoming Wang, Guixiang Pan, Yan Zhu, Yuxin Feng
Summary: This study identified the major risk factors leading to adverse reactions to traditional Chinese medicine (TCM), including risks from the herbs and their administration, as well as risks related to human physiology, pathology, and genetics. The study also analyzed the effects of toxic Chinese herbs and discussed common chemical substances, toxic mechanisms, and detoxification methods. Additionally, methodological studies on TCM toxicity were discussed, and a systematic evaluation strategy for toxic Chinese medicines was proposed.
JOURNAL OF HERBAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Xiaolin Wang, Yanfang Yang, Dan Zhao, Shuang Zhang, Yi Chen, Yuanli Chen, Ke Feng, Xiaoju Li, Jihong Han, Yasuko Iwakiri, Yajun Duan, Xiaoxiao Yang
Summary: This study investigated the effect of Nogo protein on obesity and related metabolic disorders. It was found that reduced levels of Nogo protected mice against high-fat diet-induced obesity and metabolic disorders. Furthermore, Nogo deficiency increased thermogenesis and energy metabolism, while inhibiting NF-κB-mediated inflammation, suggesting that inhibiting Nogo may be a potential strategy for obesity treatment.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Plant Sciences
Yuying Wang, Xiaoqing Sang, Rui Shao, Honglin Qin, Xuanhao Chen, Zhifeng Xue, Lin Li, Yu Wang, Yan Zhu, Yanxu Chang, Xiumei Gao, Boli Zhang, Han Zhang, Jian Yang
Summary: Xuanfei Baidu Decoction has protective effects against acute inflammation and pulmonary fibrosis by inhibiting the IL-6/STAT3 signaling pathway to protect against macrophage-induced inflammation and pulmonary fibrosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
BuChun Zhang, Rong Huang, DaiGang Yang, GuiLan Chen, YuanLi Chen, Jihong Han, Shuang Zhang, LiKun Ma, XiaoXiao Yang
Summary: Colchicine exerts antithrombotic function by attenuating platelet activation, reducing oxidative stress, and inhibiting inflammation, suggesting a potential new strategy for clinical treatment.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Chemistry, Medicinal
Zhouling Xie, Shuzeng Hou, Xiaoxiao Yang, Yajun Duan, Jihong Han, Qin Wang, Chenzhong Liao
Summary: Inhibition of CDK has proven to be an effective strategy for treating various diseases, particularly cancer. However, the development of CDK inhibitors has faced difficulties and misunderstandings, such as inadequate understanding of CDK's biological functions and the overlooking of the importance of multi-CDK inhibitors. This article summarizes and discusses these issues, aiming to facilitate the discovery of more useful CDK inhibitors.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Ningning Yao, Zhiping Jia, Yongbin Tian, Shuzeng Hou, Xiaoxiao Yang, Jihong Han, Yajun Duan, Chenzhong Liao, Yi Kong, Zhouling Xie
Summary: In this study, novel selective FXIa inhibitors were identified through structure-based drug design strategies, which have extra interactions with the S2 subsite of FXIa. Compound 35 displayed good inhibitory activity against FXIa and high selectivity over PKal and other serine proteases. In vivo experiments showed that 35 exhibited significant antithrombotic activity without increasing bleeding risk and toxicity in mice, suggesting it as a promising candidate for further research.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xiaolin Wang, Yanfang Yang, Yuanli Chen, Yajun Duan, Jihong Han, Xiaoxiao Yang
Summary: This study reveals that inhibition of ERK1/2 can significantly increase ADH1 expression, which may have potential applications in the treatment of alcohol-related diseases.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Pharmacology & Pharmacy
Yongyao Gao, Xiaomeng Jiang, Daigang Yang, Wentong Guo, Dandan Wang, Ke Gong, Ying Peng, Hong Jiang, Cunyuan Shi, Yajun Duan, Yuanli Chen, Jihong Han, Xiaoxiao Yang
Summary: This study investigates the protective effects of roxadustat in alcoholic liver disease (ALD). The results show that roxadustat can reduce liver lipid accumulation, inflammation, and oxidative stress in ALD through the regulation of HIF-1α. These findings suggest that roxadustat may be a potential drug for the treatment of ALD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Dai-gang Yang, Yong-yao Gao, Ze-qun Yin, Xue-rui Wang, Xian-she Meng, Ting-feng Zou, Ya-jun Duan, Yuan-li Chen, Chen-zhong Liao, Zhou-ling Xie, Xiao-dong Fan, Lu Sun, Ji-hong Han, Xiao-xiao Yang
Summary: Sensitization of central pain and inflammatory pathways plays a critical role in migraine, and this study demonstrates that the HIF-1 alpha/NF-kappa B/inflammation pathway is involved in this process. Roxadustat, a HIF-1 alpha stabilizer, shows potential as a therapeutic option for migraine by ameliorating migraine-like behaviors and inhibiting central pain sensitization.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Plant Sciences
Yule Wang, Xinyan Liu, Wen Zhang, Shuang He, Yiqian Zhang, John Orgah, Yi Wang, Yan Zhu
Summary: This study explores the chemical basis and molecular mechanism of the anti-stroke therapy of QSYQ and its components YQ and HX. The results show that YQ and HX components synergistically protect the brain from cerebral ischemia/reperfusion injury by regulating inflammation and autophagy. These findings shed new light on the understanding of the traditional Chinese medicine principle of tonifying Qi and activating blood, particularly in ischemic stroke.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Dan Zhao, Chao Xue, Yanfang Yang, Jiaqi Li, Xiaolin Wang, Yi Chen, Shuang Zhang, Yuanli Chen, Yajun Duan, Xiaoxiao Yang, Jihong Han
Summary: This study demonstrates the important roles of PPARγ and Nogo-B in liver fibrosis. PPARγ deficiency increases susceptibility of mice to CCl4-induced liver injury and fibrosis, while Nogo-B deficiency effectively attenuates this exacerbation effect. Therefore, Nogo-B inhibition may be a potential therapeutic approach for liver fibrosis treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Medicinal
Jin Sun, Qing Yuan, Lichen Guo, Guangxu Xiao, Tong Zhang, Bing Liang, Rongmei Yao, Yan Zhu, Yue Li, Limin Hu
Summary: This study found that exosomes derived from brain endothelial cells (EC-Exo) can protect neurons by inhibiting apoptosis and promoting synaptic remodeling in the brain.
Article
Biochemistry & Molecular Biology
Zhigang Liu, Zhen Zhang, Tingfeng Zou, Mengyuan Fang, Tianxiang Wang, Huawen Meng, Yuanli Chen, Yajun Duan, Lingling Wei, Jihong Han, Qingshan Li, Xiaoxiao Yang
Summary: This study designed and synthesized a series of novel thiazole derivatives, and evaluated their anti-inflammatory and antioxidation activities. Compound F5 exhibited the most potent activity, reversed the expression of inflammation-related genes in cells, and showed protective effects in a heart failure model. The results suggest that compound F5 could be a promising agent for heart failure treatment through attenuating oxidative stress and inflammation.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ting-feng Zou, Zhi-gang Liu, Pei-chang Cao, Shi-hong Zheng, Wen-tong Guo, Tian-xiang Wang, Yuan-li Chen, Ya-jun Duan, Qing-shan Li, Chen-zhong Liao, Zhou-ling Xie, Ji-hong Han, Xiao-xiao Yang
Summary: The study investigated the therapeutic effects of fisetin, a natural flavonoid, on kidney injury caused by diabetic atherosclerosis. The results showed that fisetin effectively attenuated diabetes-exacerbated atherosclerosis and ameliorated atherosclerosis-enhanced diabetic kidney injury. Fisetin reduced oxidative stress, glycosylation end products, and inflammation while regulating the expression of proteins involved in extracellular matrix and renal fibrosis.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Chemistry, Medicinal
Zhouling Xie, Zhiwei Meng, Xiaoxiao Yang, Yajun Duan, Qin Wang, Chenzhong Liao
Summary: This article introduces FXIa as an effective and safe target for anticoagulant discovery, and discusses the recent progress in the design, discovery, structure-activity relationships, and development of small-molecule FXIa inhibitors. The strategies for identifying more selective and druggable inhibitors are also provided, which may lead to the development of more useful anticoagulant therapies.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)