Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke: their molecular targets and action mechanisms

Spongionella Secondary Metabolites Protect Mitochondrial Function in Cortical Neurons against Oxidative Stress

(2014) Marta Leirós et al.   Marine Drugs

Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development

(2014) David Newman et al.   Marine Drugs

Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success

(2014) Ana Martins et al.   Marine Drugs

PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s

(2014) Juan Carlos Corona et al.   NEUROCHEMICAL RESEARCH

Betaine suppressed Aβ generation by altering amyloid precursor protein processing

(2014) Xiu-Ping Liu et al.   NEUROLOGICAL SCIENCES

Proton-sensitive cation channels and ion exchangers in ischemic brain injury: New therapeutic targets for stroke?

(2014) Tiandong Leng et al.   PROGRESS IN NEUROBIOLOGY

Translocation of PKC by Yessotoxin in an in Vitro Model of Alzheimer’s Disease with Improvement of Tau and β-Amyloid Pathology

(2013) Eva Alonso et al.   ACS Chemical Neuroscience

Optimization of hydrolysis conditions, isolation, and identification of neuroprotective peptides derived from seahorse Hippocampus trimaculatus

(2013) Ratih Pangestuti et al.   AMINO ACIDS

Inhibition of formation of α-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease

(2013) Cristiana Faria et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

How to treat Parkinson's disease in 2013

(2013) P. F. Worth   CLINICAL MEDICINE

Thrombolytic Agents for Acute Ischaemic Stroke Treatment: The Past, Present and Future

(2013) Joyce S. Balami et al.   CNS & Neurological Disorders-Drug Targets

Benefit of 13-desmethyl Spirolide C Treatment in Triple Transgenic Mouse Model of Alzheimer Disease: Beta-Amyloid and Neuronal Markers Improvement

(2013) Eva Alonso et al.   Current Alzheimer Research

Potential Beneficial Effects of Marine Peptide on Human Neuron Health

(2013) BoMi Ryu et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Secalonic acid A protects dopaminergic neurons from 1-methyl-4-phenylpyridinium (MPP + )-induced cell death via the mitochondrial apoptotic pathway

(2013) Aifeng Zhai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inducers of Hypoxic Response: Marine Sesquiterpene Quinones Activate HIF-1

(2013) Lin Du et al.   JOURNAL OF NATURAL PRODUCTS

AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans

(2013) Biljana Georgievska et al.   JOURNAL OF NEUROCHEMISTRY

Xyloketal B Exhibits Its Antioxidant Activity through Induction of HO-1 in Vascular Endothelial Cells and Zebrafish

(2013) Zhen-Xing Li et al.   Marine Drugs

Secondary Metabolites of a Mangrove Endophytic Fungus Aspergillus terreus (No. GX7-3B) from the South China Sea

(2013) Chun-Mei Deng et al.   Marine Drugs

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease

(2013) Frank M. Longo et al.   NATURE REVIEWS DRUG DISCOVERY

Total antioxidant capacity of the diet and major neurologic outcomes in older adults

(2013) E. E. Devore et al.   NEUROLOGY

Bioactivities of six sterols isolated from marine invertebrates

(2013) Xuefeng Zhou et al.   PHARMACEUTICAL BIOLOGY

Amiloride but Not Memantine Reduces Neurodegeneration, Seizures and Myoclonic Jerks in Rats with Cardiac Arrest-Induced Global Cerebral Hypoxia and Reperfusion

(2013) Kwok Keung Tai et al.   PLoS One

Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: A challenge for neuroprotection

(2013) Julien Puyal et al.   PROGRESS IN NEUROBIOLOGY

Bryostatin Improves Survival and Reduces Ischemic Brain Injury in Aged Rats After Acute Ischemic Stroke

(2013) Zhenjun Tan et al.   STROKE

Didemnaketals D and E, bioactive terpenoids from a Red Sea ascidian Didemnum species

(2013) Gamal A. Mohamed et al.   TETRAHEDRON

Analysis of the action of gymnodimine-A and 13-desmethyl spirolide C on the mouse neuromuscular system in vivo

(2013) Riadh Marrouchi et al.   TOXICON

β-Secretase: its biology as a therapeutic target in diseases

(2013) Haibo Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Hypoxia Inducible Factor-1: Its Potential Role In Cerebral Ischemia

(2012) Neetu Singh et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

(2012) William H. Gerwick et al.   CHEMISTRY & BIOLOGY

Kinase Inhibitor Scaffolds against Neurodegenerative Diseases from a Southern Australian Ascidian,Didemnumsp.

(2012) Fabien Plisson et al.   ChemMedChem

Redox Signaling Pathways Involved in Neuronal Ischemic Preconditioning

(2012) John W. Thompson et al.   Current Neuropharmacology

Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin

(2012) Axel Bidon-Chanal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotection for Ischaemic Stroke: Translation from the Bench to the Bedside

(2012) Brad A. Sutherland et al.   International Journal of Stroke

PGC1  and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders

(2012) S. Austin et al.   JOURNAL OF CELL SCIENCE

Cyanobacterial Peptides as a Prototype for the Design of Potent β-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases

(2012) Yanxia Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

(2012) Tania Tahtouh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine

(2012) Gao-Shang Chai et al.   JOURNAL OF NEUROCHEMISTRY

Design and Synthesis of Skeletal Analogues of Gambierol: Attenuation of Amyloid-β and Tau Pathology with Voltage-Gated Potassium Channel and N-Methyl-d-aspartate Receptor Implications

(2012) Eva Alonso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Meridianins: Marine-Derived Potent Kinase Inhibitors

(2012) S. B. Bharate et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

First therapy targeting Parkinson's proteins enters clinical trials

(2012) Elie Dolgin   NATURE MEDICINE

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity

(2012) Pradeep Dewapriya et al.   NEUROTOXICOLOGY

Spiralisones A–D: acylphloroglucinol hemiketals from an Australian marine brown alga, Zonaria spiralis

(2012) Hua Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A search for BACE inhibitors reveals new biosynthetically related pyrrolidones, furanones and pyrroles from a southern Australian marine sponge, Ianthella sp.

(2012) Hua Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A search for kinase inhibitors and antibacterial agents: bromopyrrolo-2-aminoimidazoles from a deep-water Great Australian Bight sponge, Axinella sp.

(2012) Hua Zhang et al.   TETRAHEDRON LETTERS

Total synthesis and anti-cholinesterase activity of marine-derived bis-indole alkaloid fascaplysin

(2012) Sandip B. Bharate et al.   MedChemComm

New dictyodendrins as BACE inhibitors from a southern Australian marine sponge, Ianthella sp.

(2012) Hua Zhang et al.   RSC Advances

Tramiprosate in mild-to-moderate Alzheimer’s disease – a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)

(2011) Paul S. Aisen et al.   Archives of Medical Science

Mitochondrial defect and PGC-1α dysfunction in parkin-associated familial Parkinson's disease

(2011) Consiglia Pacelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neoechinulin A Impedes the Progression of Rotenone-Induced Cytotoxicity in PC12 Cells

(2011) Soichiro Akashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The Cholinergic Antagonist Gymnodimine Improves Aβ and Tau Neuropathology in an in Vitro Model of Alzheimer Disease

(2011) Eva Alonso et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Monoamine Oxidase B Inhibitors for the Treatment of Parkinsonʼs Disease

(2011) Anthony H.V. Schapira   CNS DRUGS

Lights and Shadows on Monoamine Oxidase Inhibition in Neuroprotective Pharmacological Therapies

(2011) Claudia Binda et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

New Structural Insights into Saraines A, B, and C, Macrocyclic Alkaloids from the Mediterranean Sponge Reniera (Haliclona) sarai

(2011) Andrea Defant et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

JBIR-124: a novel antioxidative agent from a marine sponge-derived fungus Penicillium citrinum SpI080624G1f01

(2011) Teppei Kawahara et al.   JOURNAL OF ANTIBIOTICS

Waixenicin A Inhibits Cell Proliferation through Magnesium-dependent Block of Transient Receptor Potential Melastatin 7 (TRPM7) Channels

(2011) Susanna Zierler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-activated Receptor α (PPARα) Induces PPARγ Coactivator 1α (PGC-1α) Gene Expression and Contributes to Thermogenic Activation of Brown Fat

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Robust Central Reduction of Amyloid-  in Humans with an Orally Available, Non-Peptidic  -Secretase Inhibitor

(2011) P. C. May et al.   JOURNAL OF NEUROSCIENCE

Neuroprotection by marine-derived compound, 11-dehydrosinulariolide, in an in vitro Parkinson’s model: a promising candidate for the treatment of Parkinson’s disease

(2011) Wu-Fu Chen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro

(2011) Eva Alonso et al.   NEUROCHEMISTRY INTERNATIONAL

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

(2011) Yuhai Zhao et al.   PLoS One

Immunoregulatory potential of marine algal toxins yessotoxin and okadaic acid in mouse T lymphocyte cell line EL-4

(2011) Alicia Martín López et al.   TOXICOLOGY LETTERS

The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease

(2011) Robert Vassar et al.   Alzheimers Research & Therapy

Synthesis and Structure Reassessment of Psammopemmin A

(2010) Matthew D. Lebar et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Evaluation of the antifouling properties of 3-alyklpyridine compounds

(2010) Daniela Blihoghe et al.   BIOFOULING

Protective effects of xyloketal B against MPP+-induced neurotoxicity in Caenorhabditis elegans and PC12 cells

(2010) Xi-lin Lu et al.   BRAIN RESEARCH

Alaternin attenuates delayed neuronal cell death induced by transient cerebral hypoperfusion in mice

(2010) Bum Young Shin et al.   FOOD AND CHEMICAL TOXICOLOGY

Platisidines A-C, N-Methylpyridinium Alkaloids from an Okinawan Marine Sponge of Plakortis Species

(2010) Jun'ichi Kobayashi et al.   HETEROCYCLES

Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease

(2010) Joseph F. Quinn et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

JBIR-59, a new sorbicillinoid, from a marine-derived fungus Penicillium citrinum SpI080624G1f01

(2010) Jun-ya Ueda et al.   JOURNAL OF ANTIBIOTICS

Xestosaprols from the Indonesian Marine SpongeXestospongiasp.

(2010) Jingqiu Dai et al.   JOURNAL OF NATURAL PRODUCTS

Topsentinols, 24-Isopropyl Steroids from the Marine SpongeTopsentiasp.

(2010) Jingqiu Dai et al.   JOURNAL OF NATURAL PRODUCTS

Clues to how alpha-synuclein damages neurons in Parkinson's disease

(2010) David Sulzer   MOVEMENT DISORDERS

Secalonic acid A reduced colchicine cytotoxicity through suppression of JNK, p38 MAPKs and calcium influx

(2010) Aifeng Zhai et al.   NEUROCHEMISTRY INTERNATIONAL

Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism

(2010) Y. Bourne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGC-1 , A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

(2010) B. Zheng et al.   Science Translational Medicine

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

(2010) Kevin W. Gillman et al.   ACS Medicinal Chemistry Letters

The lysosome and neurodegenerative diseases

(2009) L. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro

(2009) Wen-Liang Chen et al.   BIOCHEMICAL PHARMACOLOGY

The marine natural-derived inhibitors of glycogen synthase kinase-3β phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling

(2009) Mohammad A. Khanfar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Marine compound Xyloketal B protects PC12 cells against OGD-induced cell damage

(2009) Jia Zhao et al.   BRAIN RESEARCH

GSK3: A possible link between beta amyloid peptide and tau protein

(2009) Félix Hernández et al.   EXPERIMENTAL NEUROLOGY

Neoechinulin A Protects PC12 Cells against MPP+-induced Cytotoxicity

(2009) Yoshihito Kajimura et al.   JOURNAL OF ANTIBIOTICS

Recent Advances in the Identification of γ-Secretase Inhibitors To Clinically Test the Aβ Oligomer Hypothesis of Alzheimer’s Disease

(2009) Anthony F. Kreft et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioactive Diterpene Derivatives from the Marine SpongeSpongionellasp.

(2009) Mostafa E. Rateb et al.   JOURNAL OF NATURAL PRODUCTS

The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

(2009) Han-Kyu Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of a small molecule class to enhance cell-cell adhesion and attenuate prostate tumor growth and metastasis

(2009) G. V. Shah et al.   MOLECULAR CANCER THERAPEUTICS

Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association

(2009) Majid Fotuhi et al.   Nature Reviews Neurology

Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection

(2009) S. D. Buckingham et al.   PHARMACOLOGICAL REVIEWS

Xestosaprol D and E from the Indonesian marine sponge Xestospongia sp.

(2009) Natalie Millán-Aguiñaga et al.   TETRAHEDRON LETTERS

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosia n. sp

(2008) Veena S. Nukoolkarn et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products

(2008) Mudit Mudit et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cathepsin B inhibitory activities of three new phthalate derivatives isolated from seahorse, Hippocampus Kuda Bleeler

(2008) Yong Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design of new enzyme stabilizers inspired by glycosides of hyperthermophilic microorganisms

(2008) Tiago Q. Faria et al.   CARBOHYDRATE RESEARCH

Targeting Neurotrophin Receptors in the Central Nervous System

(2008) Italo Mocchetti et al.   CNS & Neurological Disorders-Drug Targets

Dietary Antioxidants as Potential Pharmacological Agents for Ischemic Stroke

(2008) A. Cherubini et al.   CURRENT MEDICINAL CHEMISTRY

Ziconotide: an update and review

(2008) Jason A Williams et al.   EXPERT OPINION ON PHARMACOTHERAPY

PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson’s disease

(2008) Naomi P. Visanji et al.   FASEB JOURNAL

NP7 protects from cell death induced by oxidative stress in neuronal and glial midbrain cultures from parkin null mice

(2008) M.A. Mena et al.   FEBS LETTERS

Acetyl- and butyrylcholinesterase inhibitory activities of sterols and phlorotannins from Ecklonia stolonifera

(2008) Na Y YOON et al.   FISHERIES SCIENCE

Paeciloxanthone, a new cytotoxic xanthone from the marine mangrove fungusPaecilomycessp. (Tree1-7)

(2008) Lu Wen et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

(2008) Scott C. Mayer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of (−)- and (+)-Debromoflustramine B and Its Analogues as Selective Butyrylcholinesterase Inhibitors

(2008) Ernesto Rivera-Becerril et al.   JOURNAL OF MEDICINAL CHEMISTRY

Meriolins (3-(Pyrimidin-4-yl)-7-azaindoles): Synthesis, Kinase Inhibitory Activity, Cellular Effects, and Structure of a CDK2/Cyclin A/Meriolin Complex†

(2008) Aude Echalier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comparison of neuroprotective and neurorestorative capabilities of rasagiline and selegiline against lactacystin-induced nigrostriatal dopaminergic degeneration

(2008) Wen Zhu et al.   JOURNAL OF NEUROCHEMISTRY

Acetylcholinesterase-Inhibiting Activity of Pyrrole Derivatives from a Novel Marine Gliding Bacterium, Rapidithrix thailandica

(2008) Yutthapong Sangnoi et al.   Marine Drugs

Aging: An important factor for the pathogenesis of neurodegenerative diseases

(2008) Tahira Farooqui et al.   MECHANISMS OF AGEING AND DEVELOPMENT