The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease
Published 2011 View Full Article
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Title
The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease
Authors
Keywords
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Journal
Alzheimers Research & Therapy
Volume 3, Issue 3, Pages 20
Publisher
Springer Nature
Online
2011-06-01
DOI
10.1186/alzrt82
References
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Note: Only part of the references are listed.- Inhibition of β-Secretasein Vivovia Antibody Binding to Unique Loops (D and F) of BACE1
- (2011) Lujia Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin
- (2011) Gina M. Finan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model
- (2010) Anh P. Truong et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability
- (2010) Michael S. Malamas et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing
- (2010) Hirokazu Okada et al. FASEB JOURNAL
- A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates A Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease
- (2010) H. Fukumoto et al. JOURNAL OF NEUROSCIENCE
- BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration
- (2010) X. Hu et al. JOURNAL OF NEUROSCIENCE
- BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization
- (2010) Brian D. Hitt et al. Molecular Neurodegeneration
- PSGL-1 function in immunity and steady state homeostasis
- (2009) Douglas A. Carlow et al. IMMUNOLOGICAL REVIEWS
- Reduced Amyloid Deposition in Mice Overexpressing RTN3 Is Adversely Affected by Preformed Dystrophic Neurites
- (2009) Q. Shi et al. JOURNAL OF NEUROSCIENCE
- Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics
- (2009) Matthew L. Hemming et al. PLoS One
- Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves
- (2008) Xiangyou Hu et al. FASEB JOURNAL
- First Demonstration of Cerebrospinal Fluid and Plasma A Lowering with Oral Administration of a -Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates
- (2008) S. Sankaranarayanan et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Boom in the development of non-peptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease
- (2008) Romano Silvestri MEDICINAL RESEARCH REVIEWS
- Efficient Inhibition of the Alzheimer's Disease -Secretase by Membrane Targeting
- (2008) L. Rajendran et al. SCIENCE
- BACE1 gene deletion: Impact on behavioral function in a model of Alzheimer's disease
- (2007) Dione Kobayashi et al. NEUROBIOLOGY OF AGING
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