Nanomedicines for developing cancer nanotherapeutics: from benchtop to bedside and beyond

An overview on the current status of cancer nanomedicines

(2018) Nasimudeen R. Jabir et al.   CURRENT MEDICAL RESEARCH AND OPINION

Potential phytocompounds for developing breast cancer therapeutics: Nature’s healing touch

(2018) Javed Iqbal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dietary isoflavones, the modulator of breast carcinogenesis: Current landscape and future perspectives

(2018) Javed Iqbal et al.   Asian Pacific Journal of Tropical Medicine

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

(2018) Susan Hua et al.   Frontiers in Pharmacology

Recent advances in anti-angiogenic nanomedicines for cancer therapy

(2018) Pravin Bhattarai et al.   Nanoscale

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

(2017) Hossein Jahangirian et al.   International Journal of Nanomedicine

Molecular imaging in nanomedicine – A developmental tool and a clinical necessity

(2017) Jason L.J. Dearling et al.   JOURNAL OF CONTROLLED RELEASE

Therapeutic T cell engineering

(2017) Michel Sadelain et al.   NATURE

Lessons from immuno-oncology: a new era for cancer nanomedicine?

(2017) Wen Jiang et al.   NATURE REVIEWS DRUG DISCOVERY

Tumor-targeted nanomedicines for cancer theranostics

(2017) Alexandra G. Arranja et al.   PHARMACOLOGICAL RESEARCH

Physical properties, biological applications and biocompatibility studies on biosynthesized single phase cobalt oxide (Co 3 O 4 ) nanoparticles via Sageretia thea (Osbeck.)

(2017) Ali Talha Khalil et al.   Arabian Journal of Chemistry

Biosynthesis of iron oxide (Fe2O3) nanoparticles via aqueous extracts of Sageretia thea (Osbeck.) and their pharmacognostic properties

(2017) Ali Talha Khalil et al.   Green Chemistry Letters and Reviews

Rethinking cancer nanotheranostics

(2017) Hongmin Chen et al.   Nature Reviews Materials

Recent progress on nanoparticle-based drug delivery systems for cancer therapy

(2017) Yanru Xin et al.   Cancer Biology & Medicine

Targeting Strategies for the Combination Treatment of Cancer Using Drug Delivery Systems

(2017) Janel Kydd et al.   Pharmaceutics

Designing nanomedicine for immuno-oncology

(2017) Wen Jiang et al.   Nature Biomedical Engineering

Nephrogenic systemic fibrosis: a serious adverse reaction to gadolinium – 1997–2006–2016. Part 2

(2016) Henrik S Thomsen   ACTA RADIOLOGICA

In vivo degeneration and the fate of inorganic nanoparticles

(2016) Neus Feliu et al.   CHEMICAL SOCIETY REVIEWS

Biodistribution and Radiation Dosimetry of the Anti-HER2 Affibody Molecule 68Ga-ABY-025 in Breast Cancer Patients

(2016) M. Sandstrom et al.   JOURNAL OF NUCLEAR MEDICINE

Green synthesis of silver nanoparticles via plant extracts: beginning a new era in cancer theranostics

(2016) Muhammad Ovais et al.   Nanomedicine

Nanomedicine applied to translational oncology: A future perspective on cancer treatment

(2016) Lisa Bregoli et al.   Nanomedicine-Nanotechnology Biology and Medicine

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

(2016) Danny N. Khalil et al.   Nature Reviews Clinical Oncology

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy

(2016) Hong-Jun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

(2016) Andrew J. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo

(2016) Susan Ashton et al.   Science Translational Medicine

Crossing the barrier: treatment of brain tumors using nanochain particles

(2016) Efstathios Karathanasis et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Theranostic barcoded nanoparticles for personalized cancer medicine

(2016) Zvi Yaari et al.   Nature Communications

Clearance Pathways and Tumor Targeting of Imaging Nanoparticles

(2015) Mengxiao Yu et al.   ACS Nano

Positron Emission Tomography Based Elucidation of the Enhanced Permeability and Retention Effect in Dogs with Cancer Using Copper-64 Liposomes

(2015) Anders E. Hansen et al.   ACS Nano

Use of a Pro-Fibrogenic Mechanism-Based Predictive Toxicological Approach for Tiered Testing and Decision Analysis of Carbonaceous Nanomaterials

(2015) Xiang Wang et al.   ACS Nano

The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment

(2015) Jinqiang Wang et al.   ACS Nano

Nanomedicine: Past, present and future – A global perspective

(2015) Esther H. Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release

(2015) Shaobo Ruan et al.   BIOMATERIALS

Dynamic imaging of PEGylated indocyanine green (ICG) liposomes within the tumor microenvironment using multi-spectral optoacoustic tomography (MSOT)

(2015) Nicolas Beziere et al.   BIOMATERIALS

Challenges in the translation and commercialization of cell therapies

(2015) Brittany P. Dodson et al.   BMC BIOTECHNOLOGY

Noninvasive Imaging of Nanomedicines and Nanotheranostics: Principles, Progress, and Prospects

(2015) Sijumon Kunjachan et al.   CHEMICAL REVIEWS

Fate and Transport of Molybdenum Disulfide Nanomaterials in Sand Columns

(2015) Jacob D. Lanphere et al.   ENVIRONMENTAL ENGINEERING SCIENCE

Nanoparticle therapeutics: Technologies and methods for overcoming cancer

(2015) Brenda Brenner S. Cerqueira et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Image-guided drug delivery: preclinical applications and clinical translation

(2015) Tarun Ojha et al.   Expert Opinion on Drug Delivery

Advanced targeted nanomedicine

(2015) Mohan C.M. Arachchige et al.   JOURNAL OF BIOTECHNOLOGY

Molecular Imaging As a Tool for Drug Development and Trial Design

(2015) Elisabeth G.E. de Vries et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer

(2015) Marika Ciprotti et al.   JOURNAL OF CLINICAL ONCOLOGY

Improving drug delivery to solid tumors: Priming the tumor microenvironment

(2015) Iftikhar Ali Khawar et al.   JOURNAL OF CONTROLLED RELEASE

The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation

(2015) Shawn Stapleton et al.   JOURNAL OF CONTROLLED RELEASE

Spatial and temporal mapping of heterogeneity in liposome uptake and microvascular distribution in an orthotopic tumor xenograft model

(2015) Sandra N. Ekdawi et al.   JOURNAL OF CONTROLLED RELEASE

Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma

(2015) M. Keyaerts et al.   JOURNAL OF NUCLEAR MEDICINE

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

(2015) Miles A. Miller et al.   Science Translational Medicine

Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung

(2015) Xiang Wang et al.   Small

Impact and effectiveness of risk mitigation strategies on the insurability of nanomaterial production: evidences from industrial case studies

(2015) Enrico Bergamaschi et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Multistage drug delivery system based on microenvironment-responsive dendrimer–gelatin nanoparticles for deep tumor penetration

(2015) Guanlian Hu et al.   RSC Advances

Nanotechnologies in Drug Delivery - An Industrial Perspective

(2015) D.V. Bazile   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Emerging Device Applications for Semiconducting Two-Dimensional Transition Metal Dichalcogenides

(2014) Deep Jariwala et al.   ACS Nano

Graphene Oxide Enhances Cellular Delivery of Hydrophilic Small Molecules by Co-incubation

(2014) Andy H. Hung et al.   ACS Nano

Inhibition of Cancer Cell Migration by Gold Nanorods: Molecular Mechanisms and Implications for Cancer Therapy

(2014) Teng Zhou et al.   ADVANCED FUNCTIONAL MATERIALS

Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs

(2014) Qihang Sun et al.   ADVANCED MATERIALS

Nanomedicines: addressing the scientific and regulatory gap

(2014) Sally Tinkle et al.   Annals of the New York Academy of Sciences

Nanomaterials for Theranostics: Recent Advances and Future Challenges

(2014) Eun-Kyung Lim et al.   CHEMICAL REVIEWS

Interactions of Graphene Oxide Nanomaterials with Natural Organic Matter and Metal Oxide Surfaces

(2014) Indranil Chowdhury et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Features of complement activation-related pseudoallergy to liposomes with different surface charge and PEGylation: Comparison of the porcine and rat responses

(2014) László Dézsi et al.   JOURNAL OF CONTROLLED RELEASE

Near Infrared Laser-Induced Targeted Cancer Therapy Using Thermoresponsive Polymer Encapsulated Gold Nanorods

(2014) Zhenjiang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe

(2014) E. Phillips et al.   Science Translational Medicine

Regulating nanomedicine: new nano tools offer great promise for the future-if regulators can solve the difficulties that hold development back

(2014) Shannon Fischer   IEEE Pulse

Barriers to advancing nanotechnology to better improve and translate nanomedicines

(2014) Yuwei Wang et al.   Frontiers of Chemical Science and Engineering

Air–Blood Barrier Translocation of Tracheally Instilled Gold Nanoparticles Inversely Depends on Particle Size

(2013) Wolfgang G. Kreyling et al.   ACS Nano

Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?

(2013) Jörg Kreuter   ADVANCED DRUG DELIVERY REVIEWS

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

(2013) U. Prabhakar et al.   CANCER RESEARCH

Advanced nuclear analytical and related techniques for the growing challenges in nanotoxicology

(2013) Chunying Chen et al.   CHEMICAL SOCIETY REVIEWS

First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies

(2013) Glen J. Weiss et al.   INVESTIGATIONAL NEW DRUGS

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

Intelligent nanomaterials for medicine: Carrier platforms and targeting strategies in the context of clinical application

(2013) Roman Lehner et al.   Nanomedicine-Nanotechnology Biology and Medicine

Antibody Therapeutics in Cancer

(2013) M. X. Sliwkowski et al.   SCIENCE

Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate

(2012) Motao Zhu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Metabolism of Nanomaterials in Vivo: Blood Circulation and Organ Clearance

(2012) Bing Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine

(2012) Xue-Qing Zhang et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer nanomedicines: So many papers and so few drugs!

(2012) Vincent J. Venditto et al.   ADVANCED DRUG DELIVERY REVIEWS

Carbon nanomaterials for electronics, optoelectronics, photovoltaics, and sensing

(2012) Deep Jariwala et al.   CHEMICAL SOCIETY REVIEWS

Best Practices in Cancer Nanotechnology: Perspective from NCI Nanotechnology Alliance

(2012) W. C. Zamboni et al.   CLINICAL CANCER RESEARCH

Personalized Nanomedicine

(2012) T. Lammers et al.   CLINICAL CANCER RESEARCH

Impact of Synthesis Methods on the Transport of Single Walled Carbon Nanotubes in the Aquatic Environment

(2012) Indranil Chowdhury et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Challenges in design of translational nanocarriers

(2012) Qihang Sun et al.   JOURNAL OF CONTROLLED RELEASE

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

(2012) Rong Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury

(2012) Xiang Wang et al.   NANO LETTERS

High Interstitial Fluid Pressure Is Associated with Tumor-Line Specific Vascular Abnormalities in Human Melanoma Xenografts

(2012) Trude G. Simonsen et al.   PLoS One

Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

(2012) Z. Cheng et al.   SCIENCE

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

(2012) J. Hrkach et al.   Science Translational Medicine

In Vivo Targeted Delivery of Nanoparticles for Theranosis

(2011) Heebeom Koo et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Role of Nanomaterials in Translational Medicine

(2011) Erin Lavik et al.   ACS Nano

Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective

(2011) S.M. Moghimi et al.   Annual Review of Pharmacology and Toxicology

Degradable Dual pH- and Temperature-Responsive Photoluminescent Dendrimers

(2011) Youqing Shen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Drug targeting to tumors: Principles, pitfalls and (pre-) clinical progress

(2011) Twan Lammers et al.   JOURNAL OF CONTROLLED RELEASE

Minimizing Oxidation and Stable Nanoscale Dispersion Improves the Biocompatibility of Graphene in the Lung

(2011) Matthew C. Duch et al.   NANO LETTERS

Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration

(2011) Carsten Schleh et al.   Nanotoxicology

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Binding of blood proteins to carbon nanotubes reduces cytotoxicity

(2011) C. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

More Effective Nanomedicines through Particle Design

(2011) Jin Wang et al.   Small

Correlating Physico-Chemical with Toxicological Properties of Nanoparticles: The Present and the Future

(2010) Pilar Rivera Gil et al.   ACS Nano

Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods

(2010) Yang Qiu et al.   BIOMATERIALS

Encapsulation Using Hyperbranched Polymers: From Research and Technologies to Emerging Applications

(2010) Muhammad Irfan et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Translational considerations for cancer nanomedicine

(2010) Stephan T. Stern et al.   JOURNAL OF CONTROLLED RELEASE

Prodrugs Forming High Drug Loading Multifunctional Nanocapsules for Intracellular Cancer Drug Delivery

(2010) Youqing Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Doxorubicin as a Molecular Nanotheranostic Agent: Effect of Doxorubicin Encapsulation in Micelles or Nanoemulsions on the Ultrasound-Mediated Intracellular Delivery and Nuclear Trafficking

(2010) Praveena Mohan et al.   MOLECULAR PHARMACEUTICS

Biocompatible Nanoscale Dispersion of Single-Walled Carbon Nanotubes Minimizes in vivo Pulmonary Toxicity

(2010) Gökhan M. Mutlu et al.   NANO LETTERS

Amphiphilic curcumin conjugate-forming nanoparticles as anticancer prodrug and drug carriers:in vitroandin vivoeffects

(2010) Huadong Tang et al.   Nanomedicine

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Fabrication of micellar nanoparticles for drug delivery through the self-assembly of block copolymers

(2010) Zachary L. Tyrrell et al.   PROGRESS IN POLYMER SCIENCE

Barrier Capacity of Human Placenta for Nanosized Materials

(2009) Peter Wick et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Facile Synthesis of Polyester Dendrimers from Sequential Click Coupling of Asymmetrical Monomers

(2009) Xinpeng Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toxicology for the twenty-first century

(2009) Thomas Hartung   NATURE

In Vivo Study of Biodistribution and Urinary Excretion of Surface-Modified Silica Nanoparticles

(2008) Xiaoxiao He et al.   ANALYTICAL CHEMISTRY

Pluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers

(2008) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

(2008) Michelle Longmire et al.   Nanomedicine

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA