Roles of type II thioesterases and their application for secondary metabolite yield improvement

Fungal Polyketide Synthase Product Chain-Length Control by Partnering Thiohydrolase

(2014) Angelica O. Zabala et al.   ACS Chemical Biology

Narrowing the gap between the promise and reality of polyketide synthases as a synthetic biology platform

(2014) Sean Poust et al.   CURRENT OPINION IN BIOTECHNOLOGY

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

(2014) Kazuya Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LovG: The Thioesterase Required for Dihydromonacolin L Release and Lovastatin Nonaketide Synthase Turnover in Lovastatin Biosynthesis

(2013) Wei Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Steps towards the synthetic biology of polyketide biosynthesis

(2013) Matthew Cummings et al.   FEMS MICROBIOLOGY LETTERS

Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides

(2013) Christopher N. Boddy   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Novel compounds produced by Streptomyces lydicus NRRL 2433 engineered mutants altered in the biosynthesis of streptolydigin

(2012) Cristina Gómez et al.   JOURNAL OF ANTIBIOTICS

Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145

(2012) Juan Pablo Gomez-Escribano et al.   Chemical Science

Analysis ofStreptomyces coelicolorPhosphopantetheinyl Transferase, AcpS, Reveals the Basis for Relaxed Substrate Specificity

(2011) Patrick Dall’Aglio et al.   BIOCHEMISTRY

Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL

(2011) John A. Kalaitzis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway inStreptomyces coelicolor

(2011) Jonathan R. Whicher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered polyketide biosynthesis and biocatalysis in Escherichia coli

(2010) Xue Gao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Thioesterase Bhp is Involved in the Formation of β-Hydroxytyrosine during Balhimycin Biosynthesis in Amycolatopsis balhimycina

(2010) Sri Mulyani et al.   CHEMBIOCHEM

Biochemical and Genetic Insights into Asukamycin Biosynthesis

(2010) Zhe Rui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induced-fit upon Ligand Binding Revealed by Crystal Structures of the Hot-dog Fold Thioesterase in Dynemicin Biosynthesis

(2010) Chong Wai Liew et al.   JOURNAL OF MOLECULAR BIOLOGY

Reduced synthesis of the Ybt siderophore or production of aberrant Ybt-like molecules activates transcription of yersiniabactin genes in Yersinia pestis

(2010) M. C. Miller et al.   MICROBIOLOGY-SGM

Thioesterases: A new perspective based on their primary and tertiary structures

(2010) David C. Cantu et al.   PROTEIN SCIENCE

Deciphering Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin and Generation of Glycosylated Derivatives

(2009) Carlos Olano et al.   CHEMISTRY & BIOLOGY

Structure and Catalytic Mechanism of the Thioesterase CalE7 in Enediyne Biosynthesis

(2009) Masayo Kotaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis

(2009) Carlos Olano et al.   NATURAL PRODUCT REPORTS

Structural insights into nonribosomal peptide enzymatic assembly lines

(2009) Alexander Koglin et al.   NATURAL PRODUCT REPORTS

Type II Thioesterase ScoT, Associated with Streptomyces coelicolor A3(2) Modular Polyketide Synthase Cpk, Hydrolyzes Acyl Residues and Has a Preference for Propionate

(2008) M. Kotowska et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Selective Removal of Aberrant Extender Units by a Type II Thioesterase for Efficient FR-008/Candicidin Biosynthesis in Streptomyces sp. Strain FR-008

(2008) Y. Zhou et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Proposed Arrangement of Proteins Forming a Bacterial Type II Polyketide Synthase

(2008) Gaetano Castaldo et al.   CHEMISTRY & BIOLOGY

Mechanism of Thioesterase-Catalyzed Chain Release in the Biosynthesis of the Polyether Antibiotic Nanchangmycin

(2008) Tiangang Liu et al.   CHEMISTRY & BIOLOGY

Structure and Functional Analysis of RifR, the Type II Thioesterase from the Rifamycin Biosynthetic Pathway

(2008) Heather B. Claxton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for the selectivity of the external thioesterase of the surfactin synthetase

(2008) Alexander Koglin et al.   NATURE