Steps towards the synthetic biology of polyketide biosynthesis

Combinatorial Domain Swaps Provide Insights into the Rules of Fungal Polyketide Synthase Programming and the Rational Synthesis of Non-Native Aromatic Products

(2013) Anna L. Vagstad et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering polyketide synthases and nonribosomal peptide synthetases

(2013) Gavin J Williams   CURRENT OPINION IN STRUCTURAL BIOLOGY

Regulation of daunorubicin biosynthesis inStreptomyces peucetius -feed forward and feedback transcriptional control

(2013) Ajithkumar Vasanthakumar et al.   JOURNAL OF BASIC MICROBIOLOGY

Thioesterase Domains of Fungal Nonreducing Polyketide Synthases Act as Decision Gates during Combinatorial Biosynthesis

(2013) Yuquan Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Engineering Fungal Nonreducing Polyketide Synthase by Heterologous Expression and Domain Swapping

(2013) Hsu-Hua Yeh et al.   ORGANIC LETTERS

A PKS/NRPS/FAS Hybrid Gene Cluster from Serratia plymuthica RVH1 Encoding the Biosynthesis of Three Broad Spectrum, Zeamine-Related Antibiotics

(2013) Joleen Masschelein et al.   PLoS One

Library of synthetic transcriptional AND gates built with split T7 RNA polymerase mutants

(2013) D. L. Shis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzyme-Directed Mutasynthesis: A Combined Experimental and Theoretical Approach to Substrate Recognition of a Polyketide Synthase

(2012) Uschi Sundermann et al.   ACS Chemical Biology

Role of a Conserved Arginine Residue in Linkers between the Ketosynthase and Acyltransferase Domains of Multimodular Polyketide Synthases

(2012) Satoshi Yuzawa et al.   BIOCHEMISTRY

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

(2012) Dušan Goranovič et al.   BMC MICROBIOLOGY

Type III polyketide synthases in natural product biosynthesis

(2012) Dayu Yu et al.   IUBMB LIFE

Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation

(2012) S. Kapur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refactoring the nitrogen fixation gene cluster from Klebsiella oxytoca

(2012) K. Temme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling holo-ACP:DH and holo-ACP:KR complexes of modular polyketide synthases: a docking and molecular dynamics study

(2012) Swadha Anand et al.   BMC STRUCTURAL BIOLOGY

Development of a Streptomyces venezuelae-Based Combinatorial Biosynthetic System for the Production of Glycosylated Derivatives of Doxorubicin and Its Biosynthetic Intermediates

(2011) Ah Reum Han et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Production of doramectin by rational engineering of the avermectin biosynthetic pathway

(2011) Jian-Bo Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Acyl-CoA Subunit Selectivity in the Pikromycin Polyketide Synthase PikAIV: Steady-State Kinetics and Active-Site Occupancy Analysis by FTICR-MS

(2011) Shilah A. Bonnett et al.   CHEMISTRY & BIOLOGY

Structure and Biosynthesis of the Marine Streptomycete Ansamycin Ansalactam A and Its Distinctive Branched Chain Polyketide Extender Unit

(2011) Micheal C. Wilson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

cis-Antisense RNA, Another Level of Gene Regulation in Bacteria

(2011) J. Georg et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Bacterial transcriptomics: what is beyond the RNA horiz-ome?

(2011) Marc Güell et al.   NATURE REVIEWS MICROBIOLOGY

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes

(2010) Chantel D. Campbell et al.   BIOPOLYMERS

Biosynthesis of rapamycin and its regulation: past achievements and recent progress

(2010) Sung Ryeol Park et al.   JOURNAL OF ANTIBIOTICS

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

(2010) SangJoon Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

(2010) Carlos Olano et al.   NATURAL PRODUCT REPORTS

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The chemical biology of modular biosynthetic enzymes

(2009) Jordan L. Meier et al.   CHEMICAL SOCIETY REVIEWS

Biosynthesis of Salinosporamides from α,β-Unsaturated Fatty Acids: Implications for Extending Polyketide Synthase Diversity

(2009) Yuan Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Traceless protein splicing utilizing evolved split inteins

(2009) S. W. Lockless et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

(2009) A. S. Eustaquio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster

(2008) A. Ramos et al.   MICROBIOLOGY-SGM

Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products

(2007) Jonathan Kennedy   NATURAL PRODUCT REPORTS