Toward metabolic engineering in the context of system biology and synthetic biology: advances and prospects

In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction inEscherichia coli

(2014) Fayin Zhu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Constraint-based modeling of heterologous pathways: Application and experimental demonstration for overproduction of fatty acids inEscherichia coli

(2014) Kuhn Ip et al.   BIOTECHNOLOGY AND BIOENGINEERING

Multivariate modular metabolic engineering for pathway and strain optimization

(2014) Bradley Walters Biggs et al.   CURRENT OPINION IN BIOTECHNOLOGY

Advancing metabolic models with kinetic information

(2014) Hannes Link et al.   CURRENT OPINION IN BIOTECHNOLOGY

Stepwise metabolic engineering of Gluconobacter oxydans WSH-003 for the direct production of 2-keto-l-gulonic acid from d-sorbitol

(2014) Lili Gao et al.   METABOLIC ENGINEERING

Spatial modulation of key pathway enzymes by DNA-guided scaffold system and respiration chain engineering for improved N-acetylglucosamine production by Bacillus subtilis

(2014) Yanfeng Liu et al.   METABOLIC ENGINEERING

Generation of an atlas for commodity chemical production in Escherichia coli and a novel pathway prediction algorithm, GEM-Path

(2014) Miguel A. Campodonico et al.   METABOLIC ENGINEERING

Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production

(2014) Justyna Nocon et al.   METABOLIC ENGINEERING

In vitro metabolic engineering of hydrogen production at theoretical yield from sucrose

(2014) Suwan Myung et al.   METABOLIC ENGINEERING

Ensemble Modeling for Robustness Analysis in engineering non-native metabolic pathways

(2014) Yun Lee et al.   METABOLIC ENGINEERING

Modular pathway engineering of Bacillus subtilis for improved N-acetylglucosamine production

(2014) Yanfeng Liu et al.   METABOLIC ENGINEERING

Metabolic flux redirection from a central metabolic pathway toward a synthetic pathway using a metabolic toggle switch

(2014) Yuki Soma et al.   METABOLIC ENGINEERING

One step DNA assembly for combinatorial metabolic engineering

(2014) Pieter Coussement et al.   METABOLIC ENGINEERING

Kinetic models in industrial biotechnology – Improving cell factory performance

(2014) Joachim Almquist et al.   METABOLIC ENGINEERING

Enhancement of acetoin production in Candida glabrata by in silico-aided metabolic engineering

(2014) Shubo Li et al.   Microbial Cell Factories

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

A brief history of synthetic biology

(2014) D. Ewen Cameron et al.   NATURE REVIEWS MICROBIOLOGY

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

(2014) Chris J. Paddon et al.   NATURE REVIEWS MICROBIOLOGY

Improving fatty acids production by engineering dynamic pathway regulation and metabolic control

(2014) P. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein design in systems metabolic engineering for industrial strain development

(2013) Zhen Chen et al.   Biotechnology Journal

Advances in metabolic pathway and strain engineering paving the way for sustainable production of chemical building blocks

(2013) Yun Chen et al.   CURRENT OPINION IN BIOTECHNOLOGY

Glutathione enhances 2-keto-l-gulonic acid production based on Ketogulonicigenium vulgare model iWZ663

(2013) Zheng Huang et al.   JOURNAL OF BIOTECHNOLOGY

Multivariate modular metabolic engineering of Escherichia coli to produce resveratrol from l-tyrosine

(2013) Junjun Wu et al.   JOURNAL OF BIOTECHNOLOGY

Reconstruction and analysis of the industrial strain Bacillus megaterium WSH002 genome-scale in silico metabolic model

(2013) Wei Zou et al.   JOURNAL OF BIOTECHNOLOGY

Pathway engineering of Bacillus subtilis for microbial production of N-acetylglucosamine

(2013) Yanfeng Liu et al.   METABOLIC ENGINEERING

Targeting enzymes to the right compartment: Metabolic engineering for itaconic acid production by Aspergillus niger

(2013) Marzena L. Blumhoff et al.   METABOLIC ENGINEERING

Metabolic engineering of Torulopsis glabrata for malate production

(2013) Xiulai Chen et al.   METABOLIC ENGINEERING

Engineering of carboligase activity reaction in Candida glabrata for acetoin production

(2013) Shubo Li et al.   METABOLIC ENGINEERING

Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols

(2013) José L Avalos et al.   NATURE BIOTECHNOLOGY

Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs

(2013) Dokyun Na et al.   NATURE BIOTECHNOLOGY

Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica

(2013) Zhixiong Xue et al.   NATURE BIOTECHNOLOGY

Spanning high-dimensional expression space using ribosome-binding site combinatorics

(2013) Lior Zelcbuch et al.   NUCLEIC ACIDS RESEARCH

Modular optimization of multi-gene pathways for fatty acids production in E. coli

(2013) Peng Xu et al.   Nature Communications

Genome-scale metabolic model in guiding metabolic engineering of microbial improvement

(2012) Chuan Xu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Reconstruction and analysis of a genome-scale metabolic model of the vitamin C producing industrial strain Ketogulonicigenium vulgare WSH-001

(2012) Wei Zou et al.   JOURNAL OF BIOTECHNOLOGY

Metabolic engineering of Escherichia coli BL21 for biosynthesis of heparosan, a bioengineered heparin precursor

(2012) Chunyu Zhang et al.   METABOLIC ENGINEERING

Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy

(2012) Junjun Wu et al.   METABOLIC ENGINEERING

Reconstruction and analysis of the genome-scale metabolic network of Candida glabrata

(2012) Nan Xu et al.   Molecular BioSystems

Systems metabolic engineering of microorganisms for natural and non-natural chemicals

(2012) Jeong Wook Lee et al.   Nature Chemical Biology

Designing and using RNA scaffolds to assemble proteins in vivo

(2012) Camille J Delebecque et al.   Nature Protocols

Fumaric Acid Production in Saccharomyces cerevisiae by In Silico Aided Metabolic Engineering

(2012) Guoqiang Xu et al.   PLoS One

Synthetic Biology and Metabolic Engineering

(2012) Gregory Stephanopoulos   ACS Synthetic Biology

Modular Engineering of l-Tyrosine Production in Escherichia coli

(2011) Darmawi Juminaga et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Regulation and control of metabolic fluxes in microbes

(2011) Luca Gerosa et al.   CURRENT OPINION IN BIOTECHNOLOGY

Synthetic scaffolds increased resveratrol biosynthesis in engineered yeast cells

(2011) Yechun Wang et al.   JOURNAL OF BIOTECHNOLOGY

Optimization of a blueprint for in vitro glycolysis by metabolic real-time analysis

(2011) Matthias Bujara et al.   Nature Chemical Biology

Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol

(2011) Harry Yim et al.   Nature Chemical Biology

DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency

(2011) Robert J. Conrado et al.   NUCLEIC ACIDS RESEARCH

In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli

(2011) X. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control

(2010) E. Leonard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Synthetic protein scaffolds provide modular control over metabolic flux

(2009) John E Dueber et al.   NATURE BIOTECHNOLOGY

Stabilized gene duplication enables long-term selection-free heterologous pathway expression

(2009) Keith E J Tyo et al.   NATURE BIOTECHNOLOGY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS