NADPH Oxidases in Vascular Pathology

Reduced Atherosclerotic Burden in Subjects With Genetically Determined Low Oxidative Stress

(2013) Francesco Violi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Toll-Like Receptor 4 Mutation Protects Obese Mice Against Endothelial Dysfunction by Decreasing NADPH Oxidase Isoforms 1 and 4

(2013) Chao-Fan Liang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A 28-kDa Splice Variant of NADPH Oxidase-4 Is Nuclear-Localized and Involved in Redox Signaling in Vascular Cells

(2013) Narayana Anilkumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation

(2013) Felix Jansen et al.   CARDIOVASCULAR RESEARCH

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

Mechanisms of oxidative stress in human aortic aneurysms — Association with clinical risk factors for atherosclerosis and disease severity

(2013) Bartłomiej Guzik et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Adaptive immunity in atherogenesis: new insights and therapeutic approaches

(2013) Andrew H. Lichtman et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia/reperfusion injury

(2013) Vincent Braunersreuther et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Nox4 Inhibitor GKT137831 Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation

(2012) David E. Green et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Noxa1 as a moderate activator of Nox2-based NADPH oxidase

(2012) Masahito Kawano et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Arterial and Venous Endothelia Display Differential Functional Fractalkine (CX 3 CL1) Expression by Angiotensin-II

(2012) Cristina Rius et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE−/− mice

(2012) Gillian Douglas et al.   CARDIOVASCULAR RESEARCH

HSP90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis

(2012) Julio Madrigal-Matute et al.   CARDIOVASCULAR RESEARCH

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

Molecular Imaging of Inflammation and Platelet Adhesion in Advanced Atherosclerosis Effects of Antioxidant Therapy With NADPH Oxidase Inhibition

(2012) Yani Liu et al.   Circulation-Cardiovascular Imaging

Reversal of Vascular Macrophage Accumulation and Hypertension by a CCR2 Antagonist in Deoxycorticosterone/Salt-Treated Mice

(2012) Christopher T. Chan et al.   HYPERTENSION

Role of the NADPH Oxidases in the Subfornical Organ in Angiotensin II–Induced Hypertension

(2012) Heinrich E. Lob et al.   HYPERTENSION

Role of Nox isoforms in angiotensin II-induced oxidative stress and endothelial dysfunction in brain

(2012) Sophocles Chrissobolis et al.   JOURNAL OF APPLIED PHYSIOLOGY

Dynamic T cell–APC interactions sustain chronic inflammation in atherosclerosis

(2012) Ekaterina K. Koltsova et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting NADPH oxidases in vascular pharmacology

(2012) Agata Schramm et al.   VASCULAR PHARMACOLOGY

XJP-1 protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by inhibiting NADPH oxidase subunit expression and modulating the PI3K/Akt/eNOS pathway

(2012) Rong Fu et al.   VASCULAR PHARMACOLOGY

PVN adenovirus-siRNA injections silencing either NOX2 or NOX4 attenuate aldosterone/NaCl-induced hypertension in mice

(2011) Baojian Xue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

(2011) Robin Ray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

No Superoxide—No Stress?

(2011) Ralf P. Brandes et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH Oxidase 4 Mediates Monocyte Priming and Accelerated Chemotaxis Induced by Metabolic Stress

(2011) Sarah Ullevig et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

(2011) Vincent Jaquet et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity

(2011) Yury I. Miller et al.   CIRCULATION RESEARCH

The Nox Family of NADPH Oxidases: Friend or Foe of the Vascular System?

(2011) Ina Takac et al.   CURRENT HYPERTENSION REPORTS

Anti-Atherosclerotic Effects of Dihomo-.GAMMA.-Linolenic Acid in ApoE-Deficient Mice

(2011) Shinji Takai et al.   Journal of Atherosclerosis and Thrombosis

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nox2 and Nox4 mediate tumour necrosis factor-α-induced ventricular remodelling in mice

(2011) K. T. Moe et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation

(2011) Gregory J. Gatto et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

(2011) Sarah Garrido-Urbani et al.   PLoS One

Tyrphostin AG490 reduces NAPDH oxidase activity and expression in the aorta of hypercholesterolemic apolipoprotein E-deficient mice

(2011) Ioana M. Fenyo et al.   VASCULAR PHARMACOLOGY

Angiotensin II-derived reactive oxygen species underpinning the processing of the cardiovascular reflexes in the medulla oblongata

(2011) Valdir A. Braga et al.   Neuroscience Bulletin

Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling

(2010) Anna E. Dikalova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

PPARγ regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-κB

(2010) Xianghuai Lu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Preoperative Atorvastatin Treatment in CABG Patients Rapidly Improves Vein Graft Redox State by Inhibition of Rac1 and NADPH-Oxidase Activity

(2010) C. Antoniades et al.   CIRCULATION

Inhibition and Genetic Ablation of the B7/CD28 T-Cell Costimulation Axis Prevents Experimental Hypertension

(2010) Antony Vinh et al.   CIRCULATION

Oxidative Stress and Endothelial Dysfunction in Aortas of Aged Spontaneously Hypertensive Rats by NOX1/2 Is Reversed by NADPH Oxidase Inhibition

(2010) Sven Wind et al.   HYPERTENSION

Inflammation, Immunity, and Hypertension

(2010) David G. Harrison et al.   HYPERTENSION

Apocynin restores endothelial dysfunction in streptozotocin diabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions

(2010) Murat Olukman et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kappaB

(2010) Jose L Miguel Carrasco et al.   Journal of Inflammation-London

Seasonal superoxide overproduction and endothelial activation in guinea-pig heart; seasonal oxidative stress in rats and humans

(2010) Anna Konior et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Seasonal Reduction in Physical Activity and Flow-Mediated Dilation in Children

(2010) NICOLA DOMINIQUE HOPKINS et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

The NADPH Oxidase Subunit NOX4 Is a New Target Gene of the Hypoxia-inducible Factor-1

(2010) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

(2010) Christoph Kleinschnitz et al.   PLOS BIOLOGY

Oxidative Stress in the Sympathetic Premotor Neurons Contributes to Sympathetic Activation in Renovascular Hypertension

(2009) E. B. Oliveira-Sales et al.   AMERICAN JOURNAL OF HYPERTENSION

Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-α in cerebral vascular endothelial cells

(2009) Shyamali Basuroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE−/− mice

(2009) Courtney P. Judkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rosiglitazone Attenuates Chronic Hypoxia–Induced Pulmonary Hypertension in a Mouse Model

(2009) Rachel E. Nisbet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Long-Term Cyclic Strain Downregulates Endothelial Nox4

(2009) Claudia Goettsch et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms of Vascular Smooth Muscle NADPH Oxidase 1 (Nox1) Contribution to Injury-Induced Neointimal Formation

(2009) Moo Yeol Lee et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Induction of CCR2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammation

(2009) Alexandra Kadl et al.   ARTHRITIS AND RHEUMATISM

Nox4 overexpression activates reactive oxygen species and p38 MAPK in human endothelial cells

(2009) Claudia Goettsch et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tripterine prevents endothelial barrier dysfunction by inhibiting endogenous peroxynitrite formation

(2009) Feng Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca2+ pump

(2009) T Tazzeo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hereditary Deficiency of gp91 phox Is Associated With Enhanced Arterial Dilatation

(2009) Francesco Violi et al.   CIRCULATION

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

Losartan Metabolite EXP3179 Blocks NADPH Oxidase-Mediated Superoxide Production by Inhibiting Protein Kinase C

(2009) Ana Fortuño et al.   HYPERTENSION

Genetic Silencing of Nox2 and Nox4 Reveals Differential Roles of These NADPH Oxidase Homologues in the Vasopressor and Dipsogenic Effects of Brain Angiotensin II

(2009) Jeffrey R. Peterson et al.   HYPERTENSION

Induction of Hypertension and Peripheral Inflammation by Reduction of Extracellular Superoxide Dismutase in the Central Nervous System

(2009) Heinrich E. Lob et al.   HYPERTENSION

Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis

(2009) Divya Purushothaman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of Extracellular Superoxide Dismutase Leads to Acute Lung Damage in the Presence of Ambient Air

(2008) Maria Carolina Gongora et al.   AMERICAN JOURNAL OF PATHOLOGY

Reactive oxygen species from NADPH oxidase contribute to altered pulmonary vascular responses in piglets with chronic hypoxia-induced pulmonary hypertension

(2008) Candice D. Fike et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-β1 and insulin-like growth factor binding protein-3

(2008) Saleh Ismail et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Oxidant and Redox Signaling in Vascular Oxygen Sensing: Implications for Systemic and Pulmonary Hypertension

(2008) Sachin A. Gupte et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of Structural Elements in Nox1 and Nox4 Controlling Localization and Activity

(2008) Ina Helmcke et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of NADPH Oxidase in Vascular Endothelium: The Role of Phospholipases, Protein Kinases, and Cytoskeletal Proteins

(2008) Srikanth Pendyala et al.   ANTIOXIDANTS & REDOX SIGNALING

Nox4 and Nox2 NADPH Oxidases Mediate Distinct Cellular Redox Signaling Responses to Agonist Stimulation

(2008) Narayana Anilkumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nox4 Acts as a Switch Between Differentiation and Proliferation in Preadipocytes

(2008) Katrin Schröder et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of Nox2-Based NADPH Oxidase in Bone Marrow and Progenitor Cell Function Involved in Neovascularization Induced by Hindlimb Ischemia

(2008) Norifumi Urao et al.   CIRCULATION RESEARCH

NADPH Oxidases, Reactive Oxygen Species, and Hypertension: Clinical implications and therapeutic possibilities

(2008) T. M. Paravicini et al.   DIABETES CARE

Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells

(2008) Desmond B. Jay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production

(2008) S DIKALOV et al.   FREE RADICAL BIOLOGY AND MEDICINE

Renal Redox-Sensitive Signaling, but Not Blood Pressure, Is Attenuated by Nox1 Knockout in Angiotensin II–Dependent Chronic Hypertension

(2008) Alvaro Yogi et al.   HYPERTENSION

Calcium-Dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease

(2008) Tomasz J. Guzik et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6

(2008) Y Adachi et al.   ONCOGENE

Nox enzymes in immune cells

(2008) William M. Nauseef   Seminars in Immunopathology

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION