The Nox Family of NADPH Oxidases: Friend or Foe of the Vascular System?

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

(2011) Robin Ray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

α1AMP-Activated Protein Kinase Preserves Endothelial Function During Chronic Angiotensin II Treatment by Limiting Nox2 Upregulation

(2011) Swenja Schuhmacher et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

No Superoxide—No Stress?

(2011) Ralf P. Brandes et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role for Nox1 NADPH oxidase in atherosclerosis

(2011) Andrea L. Sheehan et al.   ATHEROSCLEROSIS

Nox2-derived reactive oxygen species contribute to hypercholesterolemia-induced inhibition of neovascularization: Effects on endothelial progenitor cells and mature endothelial cells

(2011) Paola Haddad et al.   ATHEROSCLEROSIS

miR-146a is modulated in human endothelial cell with aging

(2011) Mariuca Vasa-Nicotera et al.   ATHEROSCLEROSIS

Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction

(2011) Colin E. Murdoch et al.   BASIC RESEARCH IN CARDIOLOGY

Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells

(2011) Claudia Goettsch et al.   BASIC RESEARCH IN CARDIOLOGY

NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation

(2011) Siobhan M. Craige et al.   CIRCULATION

Activation of NADPH Oxidase 1 Increases Intracellular Calcium and Migration of Smooth Muscle Cells

(2011) Matthew C. Zimmerman et al.   HYPERTENSION

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GCN5 Regulates the Superoxide-Generating System in Leukocytes Via Controlling gp91-phox Gene Expression

(2011) H. Kikuchi et al.   JOURNAL OF IMMUNOLOGY

Relative contributions of mitochondria and NADPH oxidase to deoxycorticosterone acetate-salt hypertension in mice

(2011) Aihua Zhang et al.   KIDNEY INTERNATIONAL

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

(2011) Sarah Garrido-Urbani et al.   PLoS One

Regulation of NADPH Oxidase Activity Is Associated with miRNA-25-Mediated NOX4 Expression in Experimental Diabetic Nephropathy

(2010) Yibing Fu et al.   AMERICAN JOURNAL OF NEPHROLOGY

Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-α-induced apoptosis

(2010) Shyamali Basuroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertension

(2010) Carmen Capone et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hepatocyte Growth Factor Induces a Proangiogenic Phenotype and Mobilizes Endothelial Progenitor Cells by Activating Nox2

(2010) Katrin Schröder et al.   ANTIOXIDANTS & REDOX SIGNALING

An Oxidized Extracellular Oxidation-Reduction State Increases Nox1 Expression and Proliferation in Vascular Smooth Muscle Cells Via Epidermal Growth Factor Receptor Activation

(2010) Bojana Stanic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inherited Human gp91 phox Deficiency Is Associated With Impaired Isoprostane Formation and Platelet Dysfunction

(2010) Pasquale Pignatelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH oxidase-derived reactive oxygen species: involvement in vascular physiology and pathology

(2010) Adrian Manea   CELL AND TISSUE RESEARCH

Preoperative Atorvastatin Treatment in CABG Patients Rapidly Improves Vein Graft Redox State by Inhibition of Rac1 and NADPH-Oxidase Activity

(2010) C. Antoniades et al.   CIRCULATION

Nox Activator 1

(2010) Xi-Lin Niu et al.   CIRCULATION

Role of NADPH Oxidase in Endothelial Ischemia/Reperfusion Injury in Humans

(2010) Stavros P. Loukogeorgakis et al.   CIRCULATION

Pleiotropic Effects of Statins

(2010) Qian Zhou et al.   CIRCULATION JOURNAL

Nox4 is a Novel Inducible Source of Reactive Oxygen Species in Monocytes and Macrophages and Mediates Oxidized Low Density Lipoprotein–Induced Macrophage Death

(2010) Chi Fung Lee et al.   CIRCULATION RESEARCH

Local Regulation of Arterial L-Type Calcium Channels by Reactive Oxygen Species

(2010) Gregory C. Amberg et al.   CIRCULATION RESEARCH

AMPKα2 Deletion Causes Aberrant Expression and Activation of NAD(P)H Oxidase and Consequent Endothelial Dysfunction In Vivo

(2010) Shuangxi Wang et al.   CIRCULATION RESEARCH

Reactive oxygen species cause endothelial dysfunction in chronic flow overload

(2010) X. Lu et al.   JOURNAL OF APPLIED PHYSIOLOGY

NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombin-treated Vascular Smooth Muscle Cells and in Atherosclerosis

(2010) Aleksandr E. Vendrov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Modification of Nuclear Mitogen-activated Protein Kinase Phosphatase 1 Is Involved in Transforming Growth Factor β1-induced Expression of Plasminogen Activator Inhibitor 1 in Fibroblasts

(2010) Rui-Ming Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

Residual NADPH Oxidase and Survival in Chronic Granulomatous Disease

(2010) Douglas B. Kuhns et al.   NEW ENGLAND JOURNAL OF MEDICINE

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

(2010) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

(2010) M. Conrad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE−/− mice

(2009) Courtney P. Judkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Bradykinin-Induced Dilation of Human Coronary Arterioles Requires NADPH Oxidase–Derived Reactive Oxygen Species

(2009) Brandon T. Larsen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mechanisms of Vascular Smooth Muscle NADPH Oxidase 1 (Nox1) Contribution to Injury-Induced Neointimal Formation

(2009) Moo Yeol Lee et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hereditary Deficiency of gp91 phox Is Associated With Enhanced Arterial Dilatation

(2009) Francesco Violi et al.   CIRCULATION

NADPH Oxidase Nox2 Is Required for Hypoxia-Induced Mobilization of Endothelial Progenitor Cells

(2009) Katrin Schröder et al.   CIRCULATION RESEARCH

Pressure-Induced Vascular Oxidative Stress Is Mediated Through Activation of Integrin-Linked Kinase 1/βPIX/Rac-1 Pathway

(2009) Carmine Vecchione et al.   HYPERTENSION

Isoforms and Functions of NAD(P)H Oxidase at the Macula Densa

(2009) Rui Zhang et al.   HYPERTENSION

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

(2009) Annemarieke E. Loot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Is hypertension an immunologic disease?

(2009) David G. Harrison et al.   Current Cardiology Reports

Role of NOX2 in the regulation of afferent arteriole responsiveness

(2008) Mattias Carlström et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Identification of Structural Elements in Nox1 and Nox4 Controlling Localization and Activity

(2008) Ina Helmcke et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

(2008) Masuko Ushio-Fukai et al.   CANCER LETTERS

Role of Protein Tyrosine Phosphatase 1B in Vascular Endothelial Growth Factor Signaling and Cell–Cell Adhesions in Endothelial Cells

(2008) Yoshimasa Nakamura et al.   CIRCULATION RESEARCH

Redox-Sensitive Signaling by Angiotensin II Involves Oxidative Inactivation and Blunted Phosphorylation of Protein Tyrosine Phosphatase SHP-2 in Vascular Smooth Muscle Cells From SHR

(2008) Fatiha Tabet et al.   CIRCULATION RESEARCH

Role of Nox2-Based NADPH Oxidase in Bone Marrow and Progenitor Cell Function Involved in Neovascularization Induced by Hindlimb Ischemia

(2008) Norifumi Urao et al.   CIRCULATION RESEARCH

Differential vascular functions of Nox family NADPH oxidases

(2008) Ralf P Brandes et al.   CURRENT OPINION IN LIPIDOLOGY

Selective targeting of NADPH oxidase for cardiovascular protection

(2008) Alison Cave   CURRENT OPINION IN PHARMACOLOGY

Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells

(2008) Desmond B. Jay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox Regulation of Interleukin-4 Signaling

(2008) Pankaj Sharma et al.   IMMUNITY

Calcium-Dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease

(2008) Tomasz J. Guzik et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY