标题
HypoxamiRs and Cancer: From Biology to Targeted Therapy
作者
关键词
-
出版物
ANTIOXIDANTS & REDOX SIGNALING
Volume 21, Issue 8, Pages 1220-1238
出版商
Mary Ann Liebert Inc
发表日期
2013-10-11
DOI
10.1089/ars.2013.5639
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Circulating miR-210 as a Novel Hypoxia Marker in Pancreatic Cancer
- (2014) Allen S. Ho et al. Translational Oncology
- miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis
- (2013) R I McCormick et al. BRITISH JOURNAL OF CANCER
- Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice
- (2013) Eda Yildirim et al. CELL
- MicroRNA-93 Controls Perfusion Recovery After Hindlimb Ischemia by Modulating Expression of Multiple Genes in the Cell Cycle Pathway
- (2013) Surovi Hazarika et al. CIRCULATION
- MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α
- (2013) Yu-Ming Yeh et al. INTERNATIONAL JOURNAL OF CANCER
- Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis
- (2013) Zhen Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts
- (2013) Krishan Kumar et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients
- (2013) Shuwei Qiu et al. Journal of Translational Medicine
- Prognostic evaluation of microRNA-210 expression in pediatric osteosarcoma
- (2013) Haiqing Cai et al. MEDICAL ONCOLOGY
- EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2
- (2013) Jia Shen et al. NATURE
- Effects of knockdown of miR-210 in combination with ionizing radiation on human hepatoma xenograft in nude mice
- (2013) Wei Yang et al. Radiation Oncology
- MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines
- (2013) S Grosso et al. Cell Death & Disease
- Reactive oxygen species-responsive miR-210 regulates proliferation and migration of adipose-derived stem cells via PTPN2
- (2013) J H Kim et al. Cell Death & Disease
- miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia
- (2012) Deming Gou et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Concomitant Activation of miR-107/PDCD10 and Hypoxamir-210/Casp8ap2 and Their Role in Cytoprotection During Ischemic Preconditioning of Stem Cells
- (2012) Ha Won Kim et al. ANTIOXIDANTS & REDOX SIGNALING
- MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells
- (2012) Chung-Ching Chio et al. ARCHIVES OF TOXICOLOGY
- Hypoxic enhancement of exosome release by breast cancer cells
- (2012) Hamish W King et al. BMC CANCER
- MicroRNA profiling of peripheral nerve sheath tumours identifies miR-29c as a tumour suppressor gene involved in tumour progression
- (2012) N Presneau et al. BRITISH JOURNAL OF CANCER
- miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4
- (2012) H.-Y. Chen et al. CANCER RESEARCH
- Hypoxia-Inducible Factors in Physiology and Medicine
- (2012) Gregg L. Semenza CELL
- HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation
- (2012) M He et al. CELL DEATH AND DIFFERENTIATION
- MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review
- (2012) Marilena V. Iorio et al. EMBO Molecular Medicine
- Serum miR-210 as a novel biomarker for molecular diagnosis of clear cell renal cell carcinoma
- (2012) An Zhao et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro
- (2012) Wei Yang et al. EXPERIMENTAL CELL RESEARCH
- High expression of miR-210 predicts poor survival in patients with breast cancer: A meta-analysis
- (2012) Liu Hong et al. GENE
- Circulating microRNAs: New biomarkers in diagnosis, prognosis and treatment of cancer (Review)
- (2012) ALESSANDRO ALLEGRA et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- High Expression of MicroRNA-210 is an Independent Factor Indicating a Poor Prognosis in Japanese Triple-negative Breast Cancer Patients
- (2012) T. Toyama et al. JAPANESE JOURNAL OF CLINICAL ONCOLOGY
- Hypoxia-inducible Factor 1-α Induces miR-210 in Normoxic Differentiating Myoblasts
- (2012) Lucia Cicchillitti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Up-regulation of miR-210 by vascular endothelial growth factor inex vivoexpanded CD34+ cells enhances cell-mediated angiogenesis
- (2012) Mohamad Amer Alaiti et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Hypoxia-Induced MicroRNA-20a Expression Increases ERK Phosphorylation and Angiogenic Gene Expression in Endometriotic Stromal Cells
- (2012) Shih-Chieh Lin et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Identification of a Signaling Axis HIF-1α/MicroRNA-210/ISCU Independent ofSDHMutation That Defines a Subgroup of Head and Neck Paragangliomas
- (2012) Anna Merlo et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Accelerated Radiotherapy With Carbogen and Nicotinamide for Laryngeal Cancer: Results of a Phase III Randomized Trial
- (2012) Geert O. Janssens et al. JOURNAL OF CLINICAL ONCOLOGY
- miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia
- (2012) Yuan-Lei Lou et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- MiR-210 disturbs mitotic progression through regulating a group of mitosis-related genes
- (2012) Jie He et al. NUCLEIC ACIDS RESEARCH
- MicroRNA-145 inhibits the growth, invasion, metastasis and angiogenesis of neuroblastoma cells through targeting hypoxia-inducible factor 2 alpha
- (2012) H Zhang et al. ONCOGENE
- Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells
- (2012) Rui Du et al. PLoS One
- ROD1 Is a Seedless Target Gene of Hypoxia-Induced miR-210
- (2012) Pasquale Fasanaro et al. PLoS One
- Synthetic miRNA-Mowers Targeting miR-183-96-182 Cluster or miR-210 Inhibit Growth and Migration and Induce Apoptosis in Bladder Cancer Cells
- (2012) Yuchen Liu et al. PLoS One
- Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs
- (2012) C. Voellenkle et al. RNA
- miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay
- (2012) S. Djuranovic et al. SCIENCE
- MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma
- (2012) Martina Redova et al. TUMOR BIOLOGY
- microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects
- (2011) R. Kannan Mutharasan et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Targeting microRNAs involved in human diseases: A novel approach for modification of gene expression and drug development
- (2011) Roberto Gambari et al. BIOCHEMICAL PHARMACOLOGY
- Plasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients
- (2011) Eun-Jung Jung et al. CANCER
- EMT: A new vision of hypoxia promoting cancer progression
- (2011) Jian Jiang et al. CANCER BIOLOGY & THERAPY
- Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation
- (2011) C. Polytarchou et al. CANCER RESEARCH
- microRNA-Associated Progression Pathways and Potential Therapeutic Targets Identified by Integrated mRNA and microRNA Expression Profiling in Breast Cancer
- (2011) F. M. Buffa et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts
- (2011) R Faraonio et al. CELL DEATH AND DIFFERENTIATION
- Hypoxia-inducible MicroRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma
- (2011) Qiao Ying et al. HEPATOLOGY
- Expression of microRNA 210 associates with poor survival and age of tumor onset of soft-tissue sarcoma patients
- (2011) T. Greither et al. INTERNATIONAL JOURNAL OF CANCER
- Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease
- (2011) Yi Zhang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Overexpression of miR-210, a downstream target of HIF1α, causes centrosome amplification in renal carcinoma cells
- (2011) Chisato Nakada et al. JOURNAL OF PATHOLOGY
- miRNA Profiling for Clear Cell Renal Cell Carcinoma: Biomarker Discovery and Identification of Potential Controls and Consequences of miRNA Dysregulation
- (2011) Nicole M.A. White et al. JOURNAL OF UROLOGY
- Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas
- (2011) E Dejean et al. LEUKEMIA
- Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2
- (2011) C. Wu et al. MOLECULAR AND CELLULAR BIOLOGY
- A Hypoxia-Induced Positive Feedback Loop Promotes Hypoxia-Inducible Factor 1 Stability through miR-210 Suppression of Glycerol-3-Phosphate Dehydrogenase 1-Like
- (2011) T. J. Kelly et al. MOLECULAR AND CELLULAR BIOLOGY
- MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1 Activity during Prolonged Hypoxia
- (2011) U. Bruning et al. MOLECULAR AND CELLULAR BIOLOGY
- The ATM Kinase Induces MicroRNA Biogenesis in the DNA Damage Response
- (2011) Xinna Zhang et al. MOLECULAR CELL
- MicroRNAs in body fluids—the mix of hormones and biomarkers
- (2011) Maria Angelica Cortez et al. Nature Reviews Clinical Oncology
- Global MicroRNA Expression Profiling Identifies MiR-210 Associated with Tumor Proliferation, Invasion and Poor Clinical Outcome in Breast Cancer
- (2011) Françoise Rothé et al. PLoS One
- A Parsimonious Model for Gene Regulation by miRNAs
- (2011) S. Djuranovic et al. SCIENCE
- MicroRNAs in Mutagenesis, Genomic Instability, and DNA Repair
- (2011) Dan-Avi Landau et al. SEMINARS IN ONCOLOGY
- miRNA response to DNA damage
- (2011) Guohui Wan et al. TRENDS IN BIOCHEMICAL SCIENCES
- miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs
- (2011) Enrica Fabbri et al. Epigenomics
- MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration
- (2010) Joy Sarkar et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer
- (2010) Antonis Giannakakis et al. CANCER BIOLOGY & THERAPY
- MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1α Expression and Tumor Angiogenesis
- (2010) Shih-Ting Cha et al. CANCER RESEARCH
- MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT
- (2010) Zhan Zhang et al. CELL CYCLE
- miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity
- (2010) M-P Puisségur et al. CELL DEATH AND DIFFERENTIATION
- MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease
- (2010) S. Hu et al. CIRCULATION
- Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel
- (2010) Man Liu et al. CIRCULATION RESEARCH
- The MicroRNA Spectrum in 12 Body Fluids
- (2010) J. A. Weber et al. CLINICAL CHEMISTRY
- MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand
- (2010) Danish Sayed et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MicroRNA-210 Regulates Cancer Cell Proliferation through Targeting Fibroblast Growth Factor Receptor-like 1 (FGFRL1)
- (2010) Soken Tsuchiya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- miRNA profiling along tumour progression in ovarian carcinoma
- (2010) Olga Vaksman et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis
- (2010) Goutam Ghosh et al. JOURNAL OF CLINICAL INVESTIGATION
- Tirapazamine, Cisplatin, and Radiation Versus Cisplatin and Radiation for Advanced Squamous Cell Carcinoma of the Head and Neck (TROG 02.02, HeadSTART): A Phase III Trial of the Trans-Tasman Radiation Oncology Group
- (2010) Danny Rischin et al. JOURNAL OF CLINICAL ONCOLOGY
- Accurate Molecular Classification of Renal Tumors Using MicroRNA Expression
- (2010) Eddie Fridman et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers
- (2010) Lingxiao Xing et al. MODERN PATHOLOGY
- Mammalian microRNAs predominantly act to decrease target mRNA levels
- (2010) Huili Guo et al. NATURE
- Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression
- (2010) Z Chen et al. ONCOGENE
- MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU
- (2010) Elena Favaro et al. PLoS One
- Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds
- (2010) S. Biswas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
- (2010) M. Yamakuchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MiR-210 – micromanager of the hypoxia pathway
- (2010) Xin Huang et al. TRENDS IN MOLECULAR MEDICINE
- MicroRNAs in Cancer
- (2009) Ramiro Garzon et al. Annual Review of Medicine
- Role of specific microRNAs for endothelial function and angiogenesis
- (2009) Fusheng Wu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Identification and Functional Characterization of microRNAs Involved in the Malignant Progression of Gliomas
- (2009) Bastian Malzkorn et al. BRAIN PATHOLOGY
- MicroRNAs in Plasma of Pancreatic Ductal Adenocarcinoma Patients as Novel Blood-Based Biomarkers of Disease
- (2009) J. Wang et al. Cancer Prevention Research
- MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress
- (2009) M. E. Crosby et al. CANCER RESEARCH
- MicroRNAs: Target Recognition and Regulatory Functions
- (2009) David P. Bartel CELL
- MicroRNAs and Cancer: Short RNAs Go a Long Way
- (2009) Andrea Ventura et al. CELL
- MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2
- (2009) Stephen Y. Chan et al. Cell Metabolism
- AngiomiRs—Key regulators of angiogenesis
- (2009) Shusheng Wang et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis
- (2009) Hong-li Yan et al. EMBO JOURNAL
- Integrative molecular bioinformatics study of human adrenocortical tumors: microRNA, tissue-specific target prediction, and pathway analysis
- (2009) Zsófia Tömböl et al. ENDOCRINE-RELATED CANCER
- Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation
- (2009) William C.S. Cho et al. EUROPEAN JOURNAL OF CANCER
- MicroRNAs: Predictors and modifiers of chemo- and radiotherapy in different tumour types
- (2009) Richard Hummel et al. EUROPEAN JOURNAL OF CANCER
- DIFFERENTIALLY EXPRESSED MicroRNAs IN SMALL CELL LUNG CANCER
- (2009) Edit Miko et al. EXPERIMENTAL LUNG RESEARCH
- Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival
- (2009) Thomas Greither et al. INTERNATIONAL JOURNAL OF CANCER
- Ischemic Preconditioning Augments Survival of Stem Cells via miR-210 Expression by Targeting Caspase-8-associated Protein 2
- (2009) Ha Won Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An Integrated Approach for Experimental Target Identification of Hypoxia-induced miR-210
- (2009) Pasquale Fasanaro et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of hypoxia in the hallmarks of human cancer
- (2009) Kai Ruan et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation
- (2009) Xin Huang et al. MOLECULAR CELL
- Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
- (2009) G L Semenza ONCOGENE
- Ionizing Radiation-Induced Oxidative Stress Alters miRNA Expression
- (2009) Nicole L. Simone et al. PLoS One
- Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration
- (2009) Zhang Lei et al. PLoS One
- Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection
- (2009) R. E. Lanford et al. SCIENCE
- Identification of a MicroRNA Panel for Clear-cell Kidney Cancer
- (2009) David Juan et al. UROLOGY
- How mitochondria produce reactive oxygen species
- (2008) Michael P. Murphy BIOCHEMICAL JOURNAL
- Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma
- (2008) Charles H. Lawrie et al. BRITISH JOURNAL OF HAEMATOLOGY
- The Pervasive Presence of Fluctuating Oxygenation in Tumors
- (2008) L. I. Cardenas-Navia et al. CANCER RESEARCH
- Identification of Hypoxia-Inducible Factor-1 as a Novel Target for miR-17-92 MicroRNA Cluster
- (2008) A. Taguchi et al. CANCER RESEARCH
- A microRNA component of the hypoxic response
- (2008) R Kulshreshtha et al. CELL DEATH AND DIFFERENTIATION
- Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
- (2008) Xi Chen et al. CELL RESEARCH
- Role of Protein Tyrosine Phosphatase 1B in Vascular Endothelial Growth Factor Signaling and Cell–Cell Adhesions in Endothelial Cells
- (2008) Yoshimasa Nakamura et al. CIRCULATION RESEARCH
- hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer
- (2008) C. Camps et al. CLINICAL CANCER RESEARCH
- Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage
- (2008) Morten Busk et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
- (2008) Douglas D. Taylor et al. GYNECOLOGIC ONCOLOGY
- MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3
- (2008) Pasquale Fasanaro et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hypoxia response and microRNAs: no longer two separate worlds
- (2008) Mircea Ivan et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- The impact of microRNAs on protein output
- (2008) Daehyun Baek et al. NATURE
- Widespread changes in protein synthesis induced by microRNAs
- (2008) Matthias Selbach et al. NATURE
- Serum MicroRNAs Are Promising Novel Biomarkers
- (2008) Shlomit Gilad et al. PLoS One
- MicroRNA-373 induces expression of genes with complementary promoter sequences
- (2008) R. F. Place et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer
- (2008) J. A. Foekens et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Circulating microRNAs as stable blood-based markers for cancer detection
- (2008) P. S. Mitchell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The utility of LNA in microRNA-based cancer diagnostics and therapeutics
- (2008) Jan Stenvang et al. SEMINARS IN CANCER BIOLOGY
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