CD36 Upregulation Mediated by Intranasal LV-NRF2 Treatment Mitigates Hypoxia-Induced Progression of Alzheimer's-Like Pathogenesis

Microglia Demonstrate Age-Dependent Interaction with Amyloid-β Fibrils

(2018) Angela Marie Floden et al.   JOURNAL OF ALZHEIMERS DISEASE

p38 MAPK: A Mediator of Hypoxia-Induced Cerebrovascular Inflammation

(2018) Alma Sanchez et al.   JOURNAL OF ALZHEIMERS DISEASE

The Nuclear Factor Erythroid 2–Related Factor 2 Activator Oltipraz Attenuates Chronic Hypoxia–Induced Cardiopulmonary Alterations in Mice

(2013) Shunsuke Eba et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Trientine Reduces BACE1 Activity and Mitigates Amyloidosis via the AGE/RAGE/NF-κB Pathway in a Transgenic Mouse Model of Alzheimer's Disease

(2013) Chun-Yan Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

(2012) Kristina Leuner et al.   ANTIOXIDANTS & REDOX SIGNALING

CD36 is Involved in Astrocyte Activation and Astroglial Scar Formation

(2012) Yi Bao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Prenatal hypoxia may aggravate the cognitive impairment and Alzheimer’s disease neuropathology in APPSwe/PS1A246E transgenic mice

(2012) Xin Zhang et al.   NEUROBIOLOGY OF AGING

Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge

(2012) Elise L. Donovan et al.   Oxidative Medicine and Cellular Longevity

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid- 

(2011) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2, a PPARγ Alternative Pathway to Promote CD36 Expression on Inflammatory Macrophages: Implication for Malaria

(2011) David Olagnier et al.   PLoS Pathogens

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

(2010) Vittorio Calabrese et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation

(2010) Gerasimos P Sykiotis et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats

(2010) Kazim Sahin et al.   LIFE SCIENCES

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

(2010) M. T. Heneka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Hypoxia and Neurodegeneration

(2009) Chris Peers et al.   Annals of the New York Academy of Sciences

Stabilization of transcription factor Nrf2 by tBHQ prevents oxidative stress-induced amyloid β formation in NT2N neurons

(2009) Bahareh Eftekharzadeh et al.   BIOCHIMIE

The induction of HIF-1 reduces astrocyte activation by amyloid beta peptide

(2009) David Schubert et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pathological role of hypoxia in Alzheimer's disease

(2009) Xin Zhang et al.   EXPERIMENTAL NEUROLOGY

Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia

(2009) Cristina Carvalho et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Acetyl-l-carnitine (ALCAR) prevents hypobaric hypoxia–induced spatial memory impairment through extracellular related kinase–mediated nuclear factor erythroid 2-related factor 2 phosphorylation

(2009) K. Barhwal et al.   NEUROSCIENCE

Increasing Cu bioavailability inhibits A  oligomers and tau phosphorylation

(2009) P. J. Crouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

(2009) K. Kanninen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

(2009) R. L. Silverstein et al.   Science Signaling

Arsenic moiety in gallium arsenide is responsible for neuronal apoptosis and behavioral alterations in rats

(2009) Swaran J.S. Flora et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements

(2008) Atsushi Maruyama et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Oxidised LDL up-regulate CD36 expression by the Nrf2 pathway in 3T3-L1 preadipocytes

(2008) Massimo D'Archivio et al.   FEBS LETTERS

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

Relationship between oxidative stress and HIF-1α mRNA during sustained hypoxia in humans

(2008) Vincent Pialoux et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress-inducible lentiviral vectors for gene therapy

(2008) H Hurttila et al.   GENE THERAPY

Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

(2008) Hong Qing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

(2008) Katja Kanninen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Exogenous low dose hydrogen peroxide increases hypoxia-inducible factor-1alpha protein expression and induces preconditioning protection against ischemia in primary cortical neurons

(2008) Shengjun Chang et al.   NEUROSCIENCE LETTERS

Mitochondria and cellular oxygen sensing in the HIF pathway

(2007) Cormac T. Taylor   BIOCHEMICAL JOURNAL

Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

(2007) Liang Li et al.   NEUROBIOLOGY OF AGING