Article
Oncology
Meng Liao, Yiyu Li, Anhua Xiao, Qianlan Lu, Han Zeng, Hong Qin, Enze Zheng, Xiaoqing Luo, Lin Chen, Xiong Z. Ruan, Ping Yang, Yaxi Chen
Summary: This study found that the fatty acid receptor CD36 is highly expressed in ccRCC tissues and cell lines, and its overexpression enhances fatty acid uptake, lipid droplet formation, proliferation, and migration of ccRCC cells. CD36 upregulation in ccRCC is associated with hypoxia and HIF-2 alpha activation. Knockdown of CD36 in ccRCC cells reduces lipid accumulation and blocks the tumor-promoting effects of HIF-2 alpha under hypoxia.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Immunology
Guohang Xiong, Yu Feng, Xiaojia Yi, Xuedan Zhang, Xiaoyu Li, Lijuan Yang, Zihan Yi, Buqing Sai, Zhe Yang, Qiao Zhang, Yingmin Kuang, Yuechun Zhu
Summary: The study found that PRPS1 is upregulated in melanoma and promotes proliferation, migration, invasion, and inhibits apoptosis of melanoma cells. Additionally, NRF2 acts as an upstream transcription factor of PRPS1 which drives the malignant progression of melanoma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sarah Naguib, Carlisle R. R. DeJulius, Jon R. R. Backstrom, Ameer A. A. Haider, John M. M. Ang, Andrew M. M. Boal, David J. J. Calkins, Craig L. L. Duvall, Tonia S. S. Rex
Summary: EPO-R76E activates the NRF2/ARE pathway, leading to increased expression of antioxidant proteins and providing neuroprotection.
Article
Medicine, Research & Experimental
Ghali E. N. Hanuma Kumar, Sandopu Sravan Kumar, Meriga Balaji, Dharmendra Kumar Maurya, Muppuru Kesavulu
Summary: Polyphenols from Pterocarpus santalinus hydroalcoholic extract (PSHE) possess marked antioxidant, anti-inflammatory, and immunomodulatory capacities, which play important roles in the prevention of radiation damage.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Neurosciences
Ramona D'Amico, Daniela Impellizzeri, Tiziana Genovese, Roberta Fusco, Alessio Filippo Peritore, Rosalia Crupi, Livia Interdonato, Gianluca Franco, Ylenia Marino, Alessia Arangia, Enrico Gugliandolo, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, Marika Cordaro
Summary: This study explores a new neuroprotective strategy for Parkinson's disease by supplementing with Acai berry. The results show that daily supplementation with Acai berry significantly reduces motor and non-motor symptoms and protects dopaminergic neurons from damage. This beneficial effect may be attributed to the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) to counteract oxidative stress and neuroinflammation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chunyue Wang, Shanshan Chen, Hangyu Guo, Hongbo Jiang, Honghan Liu, Haoran Fu, Di Wang
Summary: Forsythoside A (FA), a main constituent of Forsythia suspensa, has been found to possess antioxidant, anti-inflammatory, and neuroprotective properties. This study investigated the potential role of FA in Alzheimer's disease (AD) and found that FA treatment improved mitochondrial function, inhibited lipid peroxidation, and reduced inflammation in AD-related cells and mice. Additionally, FA treatment attenuated memory and cognitive impairments, suppressed beta-amyloid deposition and tau hyperphosphorylation, and modulated dopamine signaling in the brain. These findings suggest that FA may have therapeutic potential as a drug component for AD treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jia-wei Li, Rong-liang Wang, Jia Xu, Kuo-yang Sun, Hui-ming Jiang, Zi-ying Sun, Zhong-yang Lv, Xing-quan Xu, Rui Wu, Hu Guo, Qing Jiang, Dong-quan Shi
Summary: The study showed that methylene blue (MB) exerts significant cartilage protection, synovitis inhibition, and pain relief in osteoarthritis (OA) rats. In human cells, MB also effectively reduces inflammatory response and oxidative stress. Additionally, MB alleviates neural inflammation by regulating the Nrf2/PRDX1 pathway in OA.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Neurosciences
Tania Arora, Vikash Prashar, Randeep Singh, Tushar Singh Barwal, Harish Changotra, Arti Sharma, Jyoti Parkash
Summary: Alzheimer's disease is characterized by the accumulation of amyloid-beta peptide and hyper-phosphorylation of tau protein, leading to neuronal degeneration and increased oxidative stress. miRNA, which regulates cellular processes, play a key role in the progression of AD. This review identifies highly dysregulated miRNAs in the brain and cerebrospinal fluid of AD patients and explores their association with various pathological processes in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Md Riad Chowdhury, Hee Kyung Jin, Jae-sung Bae
Summary: This review discusses the role of ceramide, a bioactive sphingolipid metabolite, in the progression and pathogenesis of Alzheimer's disease, and describes the ceramide synthesis pathway and its involvement in the dysregulation of homeostasis.
Article
Neurosciences
Angela Gomez-Arboledas, Klebea Carvalho, Gabriela Balderrama-Gutierrez, Shu-Hui Chu, Heidi Yahan Liang, Nicole D. Schartz, Purnika Selvan, Tiffany J. Petrisko, Miranda A. Pan, Ali Mortazavi, Andrea J. Tenner
Summary: Multiple studies have shown the involvement of the complement cascade in the progression of Alzheimer's disease, but the specific role of C5a-C5aR1 signaling in this neurodegenerative disease is still unclear. However, using the C5aR1 antagonist PMX205 in a mouse model of Alzheimer's disease has shown promising results in reducing neurodegeneration, amyloid load, and synaptic loss, suggesting its potential as a therapeutic target.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Review
Cell Biology
Song Li, Che Wang, Zhen Wang, Jun Tan
Summary: Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly population, characterized by beta-amyloid plaques and neurofibrillary tangles. Evidence suggests that cerebrovascular dysfunctions may play an important role in the development of AD, leading to potential new approaches for diagnosis, prevention, and treatment of the disease.
Article
Pharmacology & Pharmacy
Yu-Sheng Shi, Yan Zhang, Xiao Luo, Hong-Kai Yang, Yong-Sheng He
Summary: This study demonstrates that C1 can mitigate Alzheimer's disease-like pathology by activating the Nrf2 pathway and inhibiting pyroptosis, which reduces cognitive impairment and pathological damage.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Cell Biology
Shin Takasawa, Ryogo Shobatake, Asako Itaya-Hironaka, Mai Makino, Tomoko Uchiyama, Sumiyo Sakuramoto-Tsuchida, Yoshinori Takeda, Hiroyo Ota, Akiyo Yamauchi
Summary: Sleep apnoea syndrome is associated with insulin resistance and type 2 diabetes. Intermittent hypoxia (IH) stimulation increases the expression of muscle-derived insulin resistance factors in muscle cells. OCT1 and NRF2 play important roles in the IH-induced expression of IL-8, ON, and MN genes in muscle cells.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Shengxi Meng, Huize Chen, Chunjun Deng, Zeyu Meng
Summary: Alzheimer's disease is a neurodegenerative disease characterized by senile plaque deposition and neurofibrillary tangles. Chinese herbal compound prescriptions, due to their ability to act on multiple targets, systems, links, and pathways, have shown unique advantages in the research and treatment of AD. Our study found that Catalpol, the main extract of Rehmannia, could mitigate AD progression both in vitro and in vivo by promoting miR-138-5p level in neural stem cell secreted exosomes.
NEUROTOXICITY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Martin Tolar, John Hey, Aidan Power, Susan Abushakra
Summary: Research shows that inhibiting the toxicity of Aβ oligomers is an effective approach to slow or stop the progression of Alzheimer's disease, with drugs targeting other Aβ species failing to show clinical effects, while those with the APOE4 allele are more likely to benefit.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Pu Wang, Xin Yu, Pei-Pei Guan, Jing-Wen Guo, Yue Wang, Yan Zhang, Hang Zhao, Zhan-You Wang
CELLULAR & MOLECULAR IMMUNOLOGY
(2017)
Article
Neurosciences
Ling Qi, Hong-quan Yu, Yu Zhang, Li-juan Ding, Dong-hai Zhao, Peng Lv, Wei-yao Wang, Ye Xu
MOLECULAR NEUROBIOLOGY
(2017)
Article
Medicine, Research & Experimental
Qi Xie, Ye Xu, Weinan Gao, Yong Zhang, Jing Su, Yanan Liu, Yuting Guo, Minghan Dou, Kebang Hu, Liankun Sun
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2018)
Article
Oncology
Lu Xu, Qi Xie, Ling Qi, Chunyan Wang, Na Xu, Weimin Liu, Yang Yu, Songyan Li, Ye Xu
Article
Oncology
Xinxu Fu, Lu Xu, Ling Qi, Hongyan Tian, Dan Yi, Yang Yu, Shibing Liu, Songyan Li, Ye Xu, Chunyan Wang
Article
Oncology
Shuai Zhang, Rui Chai, Ying-Ying Yang, Shi-Qi Guo, Shan Wang, Tian Guo, Shuang-Feng Xu, Yan-Hui Zhang, Zhan-You Wang, Chuang Guo
Article
Geriatrics & Gerontology
Dan-Dan Li, Wei Zhang, Zhan-You Wang, Pu Zhao
FRONTIERS IN AGING NEUROSCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Chun-Yan Wang, Ye Xu, Xu Wang, Chuang Guo, Tao Wang, Zhan-You Wang
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Geriatrics & Gerontology
Zhuo Wang, Ya-Hong Zhang, Chuang Guo, Hui-Ling Gao, Man-Li Zhong, Ting-Ting Huang, Na-Na Liu, Rui-Fang Guo, Tian Lan, Wei Zhang, Zhan-You Wang, Pu Zhao
FRONTIERS IN AGING NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Yan-Hui Zhang, Da-Wei Wang, Shuang-Feng Xu, Shuai Zhang, Yong-Gang Fan, Ying-Ying Yang, Shi-Qi Guo, Shan Wang, Tian Guo, Zhan-You Wang, Chuang Guo
Article
Biochemistry & Molecular Biology
Chun-Yan Wang, Qi Zhang, Zhe Xun, Lin Yuan, Ruonan Li, Xiang Li, Shu-Yu Tian, Na Xin, Ye Xu
Article
Medicine, Research & Experimental
Yang Yu, Lu Xu, Ling Qi, Chunyan Wang, Na Xu, Shibing Liu, Songyan Li, Hongyan Tian, Weimin Liu, Ye Xu, Zhixin Li
BIOMEDICINE & PHARMACOTHERAPY
(2017)
Article
Engineering, Biomedical
Jing-Wen Guo, Pei-Pei Guan, Wei-Yan Ding, Si-Ling Wang, Xue-Shi Huang, Zhan-You Wang, Pu Wang
Article
Chemistry, Medicinal
Qing-juan Ma, Li Han, Yu Mu, Pei-pei Guan, Hui Lei, Zhan-you Wang, Xue-shi Huang
CHEMICAL & PHARMACEUTICAL BULLETIN
(2017)
Article
Medicine, Research & Experimental
Yang Yu, Qi Xie, Weimin Liu, Yuting Guo, Na Xu, Lu Xu, Shibing Liu, Songyan Li, Ye Xu, Liankun Sun
BIOMEDICINE & PHARMACOTHERAPY
(2017)