Oxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathway

Identifying targets for COPD treatment through gene expression analyses

(2016) Augustine Choi et al.   International Journal of Chronic Obstructive Pulmonary Disease

Cytokines in Pulmonary Emphysema: Can Results in Mice Be Translated to Humans?

(2013) Marcel Bonay et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Heightened Endoplasmic Reticulum Stress in the Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2009) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Meta-analyses on Suspected Chronic Obstructive Pulmonary Disease Genes

(2009) Joanna Smolonska et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oxidative Damage to Nucleic Acids in Severe Emphysema

(2009) Gaetan Deslee et al.   CHEST

Molecular pathogenesis of Parkinson disease: insights from genetic studies

(2009) Thomas Gasser   EXPERT REVIEWS IN MOLECULAR MEDICINE

Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: Roles of the MAP kinases ERK1/2and JNK

(2009) D. Goven et al.   FEBS LETTERS

IL-1R1/MyD88 Signaling Is Critical for Elastase-Induced Lung Inflammation and Emphysema

(2009) I. Couillin et al.   JOURNAL OF IMMUNOLOGY

Glucocorticoid resistance in inflammatory diseases

(2009) Peter J Barnes et al.   LANCET

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(2009) Ralf-Harto Hubner et al.   MOLECULAR MEDICINE

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

(2009) Lichuan Yang et al.   PLoS One

Ginkgo biloba extract confers protection from cigarette smoke extract-induced apoptosis in human lung endothelial cells: Role of heme oxygenase-1

(2009) Chiu-Ling Hsu et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Biomarkers of lung damage associated with tobacco smoke in induced sputum

(2009) Alessia Comandini et al.   RESPIRATORY MEDICINE

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

(2008) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Curcumin Restores Corticosteroid Function in Monocytes Exposed to Oxidants by Maintaining HDAC2

(2008) Koremu K. Meja et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Distal Airways in Mice Exposed to Cigarette Smoke

(2008) Tracy L. Adair-Kirk et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Down-Regulated NF-E2–Related Factor 2 in Pulmonary Macrophages of Aged Smokers and Patients with Chronic Obstructive Pulmonary Disease

(2008) Masaru Suzuki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Pathology of Chronic Obstructive Pulmonary Disease

(2008) James C. Hogg et al.   Annual Review of Pathology-Mechanisms of Disease

Role of HDAC2 in the Pathophysiology of COPD

(2008) Peter J. Barnes   Annual Review of Physiology

Inhibition of Urinary Bladder Carcinogenesis by Broccoli Sprouts

(2008) R. Munday et al.   CANCER RESEARCH

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

(2008) T. Ohta et al.   CANCER RESEARCH

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

(2008) Anju Singh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study

(2008) Jin-Ping Zheng et al.   LANCET

Environmental toxicity, redox signaling and lung inflammation: The role of glutathione

(2008) Saibal K. Biswas et al.   MOLECULAR ASPECTS OF MEDICINE

Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

(2008) Young-Joon Surh et al.   PLANTA MEDICA

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

(2008) T. E. Sussan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

(2008) D Goven et al.   THORAX

Review: Antioxidant therapeutic advances in COPD

(2008) Irfan Rahman   Therapeutic Advances in Respiratory Disease

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

(2007) Aruna Kode et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2

(2007) Dianne M. Walters et al.   ANTIOXIDANTS & REDOX SIGNALING