Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae

Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae – Identification of LYS228

(2018) Folkert Reck et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In Vitro Activity of LYS228, a Novel Monobactam Antibiotic, against Multidrug-Resistant Enterobacteriaceae

(2018) Johanne Blais et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Impact of Inducible blaDHA-1 on Susceptibility of Klebsiella pneumoniae Clinical Isolates to LYS228 and Identification of Chromosomal mpl and ampD Mutations Mediating Upregulation of Plasmid-Borne blaDHA-1 Expression

(2018) Adriana K. Jones et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Envelope proteome changes driven by RamA overproduction in Klebsiella pneumoniae that enhance acquired β-lactam resistance

(2017) Juan-Carlos Jiménez-Castellanos et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa

(2017) Peter Jorth et al.   mBio

Overview: Global and Local Impact of Antibiotic Resistance

(2016) Richard R. Watkins et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Combinations of mutations inenvZ,ftsI,mrdA,acrBandacrRcan cause high-level carbapenem resistance inEscherichia coli

(2016) Marlen Adler et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Comparative effects of overproducing the AraC-type transcriptional regulators MarA, SoxS, RarA and RamA on antimicrobial drug susceptibility inKlebsiella pneumoniae

(2016) Juan-Carlos Jiménez-Castellanos et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Alternatives to antibiotics—a pipeline portfolio review

(2016) Lloyd Czaplewski et al.   LANCET INFECTIOUS DISEASES

Fine-Tuning of the Cpx Envelope Stress Response Is Required for Cell Wall Homeostasis in Escherichia coli

(2016) Antoine Delhaye et al.   mBio

CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa

(2016) Zhe-Xian Tian et al.   PLoS Pathogens

Distinctive Binding of Avibactam to Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria

(2015) Abdelhamid Asli et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Interactions of OP0595, a Novel Triple-Action Diazabicyclooctane, with β-Lactams against OP0595-Resistant Enterobacteriaceae Mutants

(2015) David M. Livermore et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Escherichia coli Envelope Stress Sensor CpxA Responds to Changes in Lipid Bilayer Properties

(2015) Rebecca Keller et al.   BIOCHEMISTRY

Characterization ofEscherichia coliNDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3

(2015) Richard A. Alm et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The cell wall amidase AmiB is essential forPseudomonas aeruginosacell division, drug resistance and viability

(2015) Anastasiya A. Yakhnina et al.   MOLECULAR MICROBIOLOGY

The two-component system CpxR/A represses the expression of Salmonella virulence genes by affecting the stability of the transcriptional regulator HilD

(2015) Miguel A. De la Cruz et al.   Frontiers in Microbiology

Bacterial Resistance to Leucyl-tRNA Synthetase Inhibitor GSK2251052 Develops during Treatment of Complicated Urinary Tract Infections

(2014) Karen O'Dwyer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of the BaeSR two-component system in the regulation of Acinetobacter baumannii adeAB genes and its correlation with tigecycline susceptibility

(2014) Ming-Feng Lin et al.   BMC MICROBIOLOGY

Molecular basis of non-mutational derepression of ramA in Klebsiella pneumoniae

(2014) Shyamasree De Majumdar et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

β-Lactam Selectivity of Multidrug Transporters AcrB and AcrD Resides in the Proximal Binding Pocket

(2014) Naoki Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proliferation and significance of clinically relevant β-lactamases

(2013) Karen Bush   Annals of the New York Academy of Sciences

New β-Lactamase Inhibitors: a Therapeutic Renaissance in an MDR World

(2013) Sarah M. Drawz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

KpnEF, a New Member of the Klebsiella pneumoniae Cell Envelope Stress Response Regulon, Is an SMR-Type Efflux Pump Involved in Broad-Spectrum Antimicrobial Resistance

(2013) Vijaya Bharathi Srinivasan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Escherichia coli Cpx Envelope Stress Response Regulates Genes of Diverse Function That Impact Antibiotic Resistance and Membrane Integrity

(2013) T. L. Raivio et al.   JOURNAL OF BACTERIOLOGY

Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules

(2013) P. Nonejuie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multitarget ligands in antibacterial research: progress and opportunities

(2012) Stephen P East et al.   Expert Opinion on Drug Discovery

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Role of the Two Component Signal Transduction System CpxAR in Conferring Cefepime and Chloramphenicol Resistance in Klebsiella pneumoniae NTUH-K2044

(2012) Vijaya Bharathi Srinivasan et al.   PLoS One

The Expression Levels of Outer Membrane Proteins STM1530 and OmpD, Which Are Influenced by the CpxAR and BaeSR Two-Component Systems, Play Important Roles in the Ceftriaxone Resistance ofSalmonella entericaSerovar Typhimurium

(2011) Wensi S. Hu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Carbapenem-Resistant Enterobacteriaceae: Epidemiology and Prevention

(2011) N. Gupta et al.   CLINICAL INFECTIOUS DISEASES

Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniae

(2011) R. Rosenblum et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Discovery research: the scientific challenge of finding new antibiotics

(2011) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Characterization of the Induction and Cellular Role of the BaeSR Two-Component Envelope Stress Response of Escherichia coli

(2011) S. K. D. Leblanc et al.   JOURNAL OF BACTERIOLOGY

Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study

(2011) Timothy R Walsh et al.   LANCET INFECTIOUS DISEASES

ramR Mutations in Clinical Isolates of Klebsiella pneumoniae with Reduced Susceptibility to Tigecycline

(2010) M. Hentschke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crystal Structures of Penicillin-Binding Protein 3 from Pseudomonas aeruginosa: Comparison of Native and Antibiotic-Bound Forms

(2010) Sarah Sainsbury et al.   JOURNAL OF MOLECULAR BIOLOGY

Energy production genessucBandubiF  are involved in persister survival and tolerance to multiple antibiotics and stresses inEscherichia coli

(2009) Chao Ma et al.   FEMS MICROBIOLOGY LETTERS

Correlation of the expression of acrB and the regulatory genes marA, soxS and ramA with antimicrobial resistance in clinical isolates of Klebsiella pneumoniae endemic to New York City

(2009) S. Bratu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Real-Time PCR and Statistical Analyses of acrAB and ramA Expression in Clinical Isolates of Klebsiella pneumoniae

(2008) A. Ruzin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY