Characterization ofEscherichia coliNDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3

Avibactam and Class C β-Lactamases: Mechanism of Inhibition, Conservation of the Binding Pocket, and Implications for Resistance

(2014) S. D. Lahiri et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dual beta-lactam therapy for serious Gram-negative infections: is it time to revisit?

(2014) Christine Rahme et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

New Delhi Metallo-beta-lactamase around the world: An eReview using Google Maps

(2014) M Berrazeg et al.   Eurosurveillance

Frequent carriage of resistance mechanisms to β-lactams and biofilm formation in Haemophilus influenzae causing treatment failure and recurrent otitis media in young children

(2014) Silvia García-Cobos et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Crystal Structure of Penicillin-Binding Protein 3 (PBP3) from Escherichia coli

(2014) Eric Sauvage et al.   PLoS One

In VitroActivities of Ceftazidime-Avibactam and Aztreonam-Avibactam against 372 Gram-Negative Bacilli Collected in 2011 and 2012 from 11 Teaching Hospitals in China

(2013) Xiaojuan Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Emergence of New Delhi metallo-β-lactamase type 1-producing Enterobacteriaceae and non-Enterobacteriaceae: global case detection and bacterial surveillance

(2013) Greta Bushnell et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Novel mechanisms of resistance to β-lactam antibiotics in Haemophilus parainfluenzae: β-lactamase-negative ampicillin resistance and inhibitor-resistant TEM β-lactamases

(2013) S. García-Cobos et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases

(2013) David E. Ehmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of New Drugs for an Old Target — The Penicillin Binding Proteins

(2012) Astrid Zervosen et al.   MOLECULES

Avibactam is a covalent, reversible, non- -lactam  -lactamase inhibitor

(2012) D. E. Ehmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinctive Attributes of β-Lactam Target Proteins inAcinetobacter baumanniiRelevant to Development of New Antibiotics

(2011) Seungil Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-ProducingEnterobacteriaceae

(2010) David M. Livermore et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae

(2010) Karen Bush   CURRENT OPINION IN MICROBIOLOGY

Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Timescale for Evolution, Population Expansion, and Spatial Spread of an Emerging Clone of Methicillin-Resistant Staphylococcus aureus

(2010) Ulrich Nübel et al.   PLoS Pathogens

Characterization of a New Metallo- -Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India

(2009) D. Yong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

AmpC  -Lactamases

(2009) G. A. Jacoby   CLINICAL MICROBIOLOGY REVIEWS

PBP Active Site Flexibility as the Key Mechanism for β-Lactam Resistance in Pneumococci

(2009) Carlos Contreras-Martel et al.   JOURNAL OF MOLECULAR BIOLOGY

Affinity of Doripenem and Comparators to Penicillin-Binding Proteins in Escherichia coli and Pseudomonas aeruginosa

(2008) T. A. Davies et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains ofNeisseria gonorrhoeaeReveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance

(2008) Ailsa J. Powell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY