New β-Lactamase Inhibitors: a Therapeutic Renaissance in an MDR World
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
New β-Lactamase Inhibitors: a Therapeutic Renaissance in an MDR World
Authors
Keywords
-
Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 58, Issue 4, Pages 1835-1846
Publisher
American Society for Microbiology
Online
2013-12-31
DOI
10.1128/aac.00826-13
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- New β-lactam-β-lactamase inhibitor combinations in clinical development
- (2013) David M. Shlaes Annals of the New York Academy of Sciences
- In VitroActivity of Biapenem plus RPX7009, a Carbapenem Combined with a Serine β-Lactamase Inhibitor, against Anaerobic Bacteria
- (2013) Ellie J. C. Goldstein et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC β-Lactamases
- (2013) Sushmita D. Lahiri et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The FDA Reboot of Antibiotic Development
- (2013) David M. Shlaes et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- 10 x '20 Progress--Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America
- (2013) H. W. Boucher et al. CLINICAL INFECTIOUS DISEASES
- Investigational Antimicrobial Agents of 2013
- (2013) M. J. Pucci et al. CLINICAL MICROBIOLOGY REVIEWS
- Clawing back: broadening the notion of metal chelators in medicine
- (2013) Katherine J Franz CURRENT OPINION IN CHEMICAL BIOLOGY
- Comparative in vitro activity of ceftaroline, ceftaroline-avibactam, and other antimicrobial agents against aerobic and anaerobic bacteria cultured from infected diabetic foot wounds
- (2013) Ellie J.C. Goldstein et al. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
- β-Lactamase inhibitors: a review of the patent literature (2010 – 2013)
- (2013) John D Buynak EXPERT OPINION ON THERAPEUTIC PATENTS
- Effect of Disodium EDTA Chelation Regimen on Cardiovascular Events in Patients With Previous Myocardial Infarction
- (2013) Gervasio A. Lamas et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Activity of MK-7655 combined with imipenem against Enterobacteriaceae and Pseudomonas aeruginosa
- (2013) D. M. Livermore et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Activity of biapenem (RPX2003) combined with the boronate -lactamase inhibitor RPX7009 against carbapenem-resistant Enterobacteriaceae
- (2013) D. M. Livermore et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Comparative study of the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infections in hospitalized adults: results of a randomized, double-blind, Phase II trial
- (2013) Christopher Lucasti et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases
- (2013) David E. Ehmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Future of Antibiotics and Resistance
- (2013) Brad Spellberg et al. NEW ENGLAND JOURNAL OF MEDICINE
- “Stormy waters ahead”: global emergence of carbapenemases
- (2013) Gopi Patel et al. Frontiers in Microbiology
- Metallo-β-lactamase structure and function
- (2012) Timothy Palzkill Annals of the New York Academy of Sciences
- ComparativeIn VitroandIn VivoEfficacies of Human Simulated Doses of Ceftazidime and Ceftazidime-Avibactam against Pseudomonas aeruginosa
- (2012) Jared L. Crandon et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226
- (2012) Wei Ke et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Novel Modeling Framework To Guide Design of Optimal Dosing Strategies for β-Lactamase Inhibitors
- (2012) Pratik Bhagunde et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Activity of Ceftaroline-Avibactam Tested against Gram-Negative Organism Populations, including Strains Expressing One or More β-Lactamases and Methicillin-Resistant Staphylococcus aureus Carrying Various Staphylococcal Cassette ChromosomemecTypes
- (2012) Mariana Castanheira et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Systematic Analysis of Metallo-β-Lactamases Using an Automated Database
- (2012) Michael Widmann et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In VitroActivity of MK-7655, a Novel β-Lactamase Inhibitor, in Combination with Imipenem against Carbapenem-Resistant Gram-Negative Bacteria
- (2012) Elizabeth B. Hirsch et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In VitroAntibacterial Activity of the Ceftazidime-Avibactam (NXL104) Combination against Pseudomonas aeruginosa Clinical Isolates
- (2012) Premavathy Levasseur et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- NXL104 Irreversibly Inhibits the β-Lactamase from Mycobacterium tuberculosis
- (2012) Hua Xu et al. BIOCHEMISTRY
- Editorial Commentary: Saving Lives With Optimal Antimicrobial Chemotherapy
- (2012) G. L. Drusano et al. CLINICAL INFECTIOUS DISEASES
- White Paper: Recommendations on the Conduct of Superiority and Organism-Specific Clinical Trials of Antibacterial Agents for the Treatment of Infections Caused by Drug-Resistant Bacterial Pathogens
- (2012) CLINICAL INFECTIOUS DISEASES
- Continuous Infusion of Beta-Lactam Antibiotics in Severe Sepsis: A Multicenter Double-Blind, Randomized Controlled Trial
- (2012) J. M. Dulhunty et al. CLINICAL INFECTIOUS DISEASES
- Efficacy and safety of ceftazidime–avibactam versus imipenem–cilastatin in the treatment of complicated urinary tract infections, including acute pyelonephritis, in hospitalized adults: results of a prospective, investigator-blinded, randomized study
- (2012) José A. Vazquez et al. CURRENT MEDICAL RESEARCH AND OPINION
- Improving known classes of antibiotics: an optimistic approach for the future
- (2012) Karen Bush CURRENT OPINION IN PHARMACOLOGY
- Anti-anaerobic activity of a new β-lactamase inhibitor NXL104 in combination with β-lactams and metronidazole
- (2012) L.J. Dubreuil et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Fourteen years in resistance
- (2012) David M. Livermore INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Characterization of -lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104)
- (2012) D. M. Livermore et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- OXA-48-like carbapenemases: the phantom menace
- (2012) L. Poirel et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- In vitro activity of the siderophore monosulfactam BAL30072 against meropenem-non-susceptible Acinetobacter baumannii
- (2012) P. G. Higgins et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Efficacies of calcium–EDTA in combination with imipenem in a murine model of sepsis caused by Escherichia coli with NDM-1 β-lactamase
- (2012) Ayumi Yoshizumi et al. JOURNAL OF INFECTION AND CHEMOTHERAPY
- Design and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with a Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-Lactamase
- (2012) Marisa L. Winkler et al. JOURNAL OF MEDICINAL CHEMISTRY
- New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and Inhibition
- (2012) Dustin T. King et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Fragment-guided design of subnanomolar -lactamase inhibitors active in vivo
- (2012) O. Eidam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Probing chelation motifs in HIV integrase inhibitors
- (2012) A. Agrawal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Avibactam is a covalent, reversible, non- -lactam -lactamase inhibitor
- (2012) D. E. Ehmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pharmacodynamics of β-Lactamase Inhibition by NXL104 in Combination with Ceftaroline: Examining Organisms with Multiple Types of β-Lactamases
- (2011) Arnold Louie et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In VitroActivity of Ceftazidime-NXL104 against 396 Strains of β-Lactamase-Producing Anaerobes
- (2011) Diane M. Citron et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In VivoEfficacy of a Human-Simulated Regimen of Ceftaroline Combined with NXL104 against Extended-Spectrum-β-Lactamase (ESBL)-Producing and Non-ESBL-Producing Enterobacteriaceae
- (2011) Dora E. Wiskirchen et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Activity of NXL104 in Combination with β-Lactams against Genetically Characterized Escherichia coli and Klebsiella pneumoniae Isolates Producing Class A Extended-Spectrum β-Lactamases and Class C β-Lactamases
- (2011) P. R. S. Lagacé-Wiens et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Inactivation of a class A and a class C β-lactamase by 6β-(hydroxymethyl)penicillanic acid sulfone
- (2011) Krisztina M. Papp-Wallace et al. BIOCHEMICAL PHARMACOLOGY
- Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii
- (2011) Qiang Tan et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The identification of new metallo-β-lactamase inhibitor leads from fragment-based screening
- (2011) Peter Vella et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- 3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-β-lactamase inhibitors
- (2011) Faridoon et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors
- (2011) Ken Coleman CURRENT OPINION IN MICROBIOLOGY
- Synthesis and kinetic testing of new inhibitors for a metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa
- (2011) Mosaad S. Mohamed et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Therapeutic options for infections withEnterobacteriaceaeproducing carbapenem-hydrolyzing enzymes
- (2011) Matthew E Falagas et al. Future Microbiology
- In vitro activity of avibactam (NXL104) in combination with β-lactams against Gram-negative bacteria, including OXA-48 β-lactamase-producing Klebsiella pneumoniae
- (2011) Z. Aktaş et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Tackling antibiotic resistance
- (2011) Karen Bush et al. NATURE REVIEWS MICROBIOLOGY
- A Concise Synthesis of a β-Lactamase Inhibitor
- (2011) Ian K. Mangion et al. ORGANIC LETTERS
- Exploring sequence requirements for C3/C4carboxylate recognition in thePseudomonas aeruginosacephalosporinase: Insights into plasticity of the AmpC β-lactamase
- (2011) Sarah M. Drawz et al. PROTEIN SCIENCE
- The emerging NDM carbapenemases
- (2011) Patrice Nordmann et al. TRENDS IN MICROBIOLOGY
- Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-ProducingEnterobacteriaceae
- (2010) David M. Livermore et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Novel Insights into the Mode of Inhibition of Class A SHV-1 β-Lactamases Revealed by Boronic Acid Transition State Inhibitors
- (2010) Wei Ke et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Penicillin Sulfone Inhibitors of Class D -Lactamases
- (2010) S. M. Drawz et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Efficacy of Calcium-EDTA as an Inhibitor for Metallo- -Lactamase in a Mouse Model of Pseudomonas aeruginosa Pneumonia
- (2010) N. Aoki et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Mechanistic Studies of the Inactivation of TEM-1 and P99 by NXL104, a Novel Non- -Lactam -Lactamase Inhibitor
- (2010) T. Stachyra et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Evaluation of Ceftazidime and NXL104 in Two Murine Models of Infection Due to KPC-ProducingKlebsiella pneumoniae
- (2010) Andrea Endimiani et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structural study of phenyl boronic acid derivatives as AmpC β-lactamase inhibitors
- (2010) Donatella Tondi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- 4,7-Dichloro benzothien-2-yl sulfonylaminomethyl boronic acid: First boronic acid-derived beta-lactamase inhibitor with class A, C, and D activity
- (2010) Qiang Tan et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Three Decades of -Lactamase Inhibitors
- (2010) S. M. Drawz et al. CLINICAL MICROBIOLOGY REVIEWS
- Activity of chequerboard combinations of ceftaroline and NXL104 versus -lactamase-producing Enterobacteriaceae
- (2010) S. Mushtaq et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- In vitro activity of ceftazidime+NXL104 against Pseudomonas aeruginosa and other non-fermenters
- (2010) S. Mushtaq et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Evolving Carbapenemases: Can Medicinal Chemists Advance One Step Ahead of the Coming Storm?
- (2010) Peter Oelschlaeger et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as β-Lactamase Inhibitors
- (2010) Oliv Eidam et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cyclobutanone Analogues of β-Lactams Revisited: Insights into Conformational Requirements for Inhibition of Serine- and Metallo-β-Lactamases
- (2010) Jarrod W. Johnson et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Design, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors ofAcinetobacter baumanniiOXA-24 Carbapenemase
- (2010) German Bou et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Inhibitor Resistance in the KPC-2 -Lactamase, a Preeminent Property of This Class A -Lactamase
- (2009) K. M. Papp-Wallace et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In Vitro Activity of NXL104 in Combination with -Lactams against Klebsiella pneumoniae Isolates Producing KPC Carbapenemases
- (2009) A. Endimiani et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Diversity, Epidemiology, and Genetics of Class D -Lactamases
- (2009) L. Poirel et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Updated Functional Classification of -Lactamases
- (2009) K. Bush et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Inhibition of the Class C β-Lactamase fromAcinetobacterspp.: Insights into Effective Inhibitor Design
- (2009) Sarah M. Drawz et al. BIOCHEMISTRY
- Risk factors for extended-spectrum β-lactamase positivity in uropathogenic Escherichia coli isolated from community-acquired urinary tract infections
- (2009) Ö.K. Azap et al. CLINICAL MICROBIOLOGY AND INFECTION
- In vitro activity of the -lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases
- (2009) T. Stachyra et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Acinetobacter baumannii: Emergence of a Successful Pathogen
- (2008) A. Y. Peleg et al. CLINICAL MICROBIOLOGY REVIEWS
- Metallo-β-lactamases in Gram-negative bacteria: introducing the era of pan-resistance?
- (2008) Helen C. Maltezou INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum -lactamases and carbapenemases
- (2008) D. M. Livermore et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Structural basis for the broad-spectrum inhibition of metallo-β-lactamases by thiols
- (2008) Benoît M. R. Liénard et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Structure-based optimization of cephalothin-analogue boronic acids as β-lactamase inhibitors
- (2007) Stefania Morandi et al. BIOORGANIC & MEDICINAL CHEMISTRY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now