Solid-Phase Biological Assays for Drug Discovery

Antibody microarrays for high-throughput, multianalyte analysis

(2017) Hongjun Jin et al.   Cancer Biomarkers

Immobilized purine nucleoside phosphorylase from Schistosoma mansoni for specific inhibition studies

(2013) Marcela Cristina de Moraes et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Fragment Screening by Weak Affinity Chromatography: Comparison with Established Techniques for Screening against HSP90

(2013) Elinor Meiby et al.   ANALYTICAL CHEMISTRY

Analysis of Plk1-Bora interaction using a protein chip system

(2013) Jung-kyu Lee et al.   BioChip Journal

ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation

(2013) Karla LH Feijs et al.   Cell Communication and Signaling

Enzymatic reactions on immobilised substrates

(2013) Christopher J. Gray et al.   CHEMICAL SOCIETY REVIEWS

Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection

(2013) C. Temporini et al.   JOURNAL OF CHROMATOGRAPHY A

Acetylcholinesterase Immobilized Capillary Reactors–Tandem Mass Spectrometry: An On-Flow Tool for Ligand Screening

(2013) Kenia L. Vanzolini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and Properties of Tethered Bilayer Lipid Membranes with Unsaturated Anchor Molecules

(2013) Rima Budvytyte et al.   LANGMUIR

Multispot, label-free biodetection at a phantom plastic–water interface

(2013) Fabio Giavazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular basis of targeting protein kinases in cancer therapeutics

(2013) Chung-Jung Tsai et al.   SEMINARS IN CANCER BIOLOGY

Lipid bilayer technologies in ion channel recordings and their potential in drug screening assay

(2013) Patthara Kongsuphol et al.   SENSORS AND ACTUATORS B-CHEMICAL

A multiplexed screening method for agonists and antagonists of the estrogen receptor protein

(2012) Zhonghui Li et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A Highly-Sensitive Colorimetric Assay Method for Antibody Array Based on an Tyramide Signal Amplification System

(2012) Qing Chen et al.   ANALYTICAL LETTERS

In Vitro Expressed GPCR Inserted in Polymersome Membranes for Ligand-Binding Studies

(2012) Sylvia May et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymes on material surfaces

(2012) Joey N. Talbert et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Current advances in peptide and small molecule microarray technologies

(2012) Yu M Foong et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Ligand–receptor interaction platforms and their applications for drug discovery

(2012) Ye Fang   Expert Opinion on Drug Discovery

Affinity proteomics: the role of specific binding reagents in human proteome analysis

(2012) Oda Stoevesandt et al.   Expert Review of Proteomics

A Lectin from the MusselMytilus galloprovincialisHas a Highly Novel Primary Structure and Induces Glycan-mediated Cytotoxicity of Globotriaosylceramide-expressing Lymphoma Cells

(2012) Yuki Fujii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive two-dimensional HepG2/cell membrane chromatography/monolithic column/time-of-flight mass spectrometry system for screening anti-tumor components from herbal medicines

(2012) Xiaofei Chen et al.   JOURNAL OF CHROMATOGRAPHY A

Optimization of human serum albumin monoliths for chiral separations and high-performance affinity chromatography

(2012) Erika L. Pfaunmiller et al.   JOURNAL OF CHROMATOGRAPHY A

The synthesis and characterization of a nuclear membrane affinity chromatography column for the study of human breast cancer resistant protein (BCRP) using nuclear membranes obtained from the LN-229 cells

(2012) K.-L. Habicht et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Flow-through immobilized enzyme reactors based on monoliths: II. Kinetics study and application

(2012) Evgenia G. Vlakh et al.   JOURNAL OF SEPARATION SCIENCE

A high-throughput surface plasmon resonance biosensor based on differential interferometric imaging

(2012) Daqian Wang et al.   MEASUREMENT SCIENCE and TECHNOLOGY

Measuring substrate binding and affinity of purified membrane transport proteins using the scintillation proximity assay

(2012) Daniel Harder et al.   Nature Protocols

Combining label-free technologies: discovery in strength

(2012) Robin Barbour et al.   Bioanalysis

Challenges in the Development of Functional Assays of Membrane Proteins

(2012) Louis Tiefenauer et al.   Materials

Optimizing microarray-based in situ transcription–translation of proteins for matrix-assisted laser desorption ionization mass spectrometry

(2011) Michael J. Kimzey et al.   ANALYTICAL BIOCHEMISTRY

Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening

(2011) R. Moaddel et al.   ANALYTICAL BIOCHEMISTRY

Continuous Flow Immobilized Enzyme Reactor–Tandem Mass Spectrometry for Screening of AChE Inhibitors in Complex Mixtures

(2011) Erica M. Forsberg et al.   ANALYTICAL CHEMISTRY

Validation of an Optical Microplate Label-Free Platform in the Screening of Chemical Libraries for Direct Binding to a Nuclear Receptor

(2011) Laura Vela et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Artificial membrane-like environments for in vitro studies of purified G-protein coupled receptors

(2011) Eugene Serebryany et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Exploiting nature's rich source of proteasome inhibitors as starting points in drug development

(2011) Melissa Ann Gräwert et al.   CHEMICAL COMMUNICATIONS

Tailoring Sol–Gel-Derived Silica Materials for Optical Biosensing

(2011) Maria Rowena N. Monton et al.   CHEMISTRY OF MATERIALS

Materials Screening for Sol–Gel-Derived High-Density Multi-Kinase Microarrays

(2011) Xin Ge et al.   CHEMISTRY OF MATERIALS

Ligand-based receptor tyrosine kinase partial agonists: new paradigm for cancer drug discovery?

(2011) David J Riese   Expert Opinion on Drug Discovery

YajL, Prokaryotic Homolog of Parkinsonism-associated Protein DJ-1, Functions as a Covalent Chaperone for Thiol Proteome

(2011) Hai-Tuong Le et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The development and characterization of protein-based stationary phases for studying drug–protein and protein–protein interactions

(2011) Mitesh Sanghvi et al.   JOURNAL OF CHROMATOGRAPHY A

Vinyl functionalized silica hybrid monolith-based trypsin microreactor for on line digestion and separation via thiol-ene “click” strategy

(2011) Yingzhuang Chen et al.   JOURNAL OF CHROMATOGRAPHY A

Mixed-bed chromatography as a way to resolve peculiar protein fractionation situations

(2011) Egisto Boschetti et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Secretome profiling with antibody microarrays

(2011) Shakhawan Abdulrahman Mustafa et al.   Molecular BioSystems

A Sol−Gel-Derived Acetylcholinesterase Microarray for Nanovolume Small-Molecule Screening

(2010) Maria Rowena N. Monton et al.   ANALYTICAL CHEMISTRY

Measuring Binding Kinetics of Ligands with Tethered Receptors by Fluorescence Polarization and Total Internal Reflection Fluorescence

(2010) Ka-Cheung Kwok et al.   ANALYTICAL CHEMISTRY

Bilayer lipid membranes supported on Teflon filters: A functional environment for ion channels

(2010) Thai Phung et al.   BIOSENSORS & BIOELECTRONICS

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Control of protein immobilization: Coupling immobilization and site-directed mutagenesis to improve biocatalyst or biosensor performance

(2010) Karel Hernandez et al.   ENZYME AND MICROBIAL TECHNOLOGY

Cell-based apoptosis assays in oncology drug discovery

(2010) John Drewe et al.   Expert Opinion on Drug Discovery

Analysis of drug–protein binding by ultrafast affinity chromatography using immobilized human serum albumin

(2010) Rangan Mallik et al.   JOURNAL OF CHROMATOGRAPHY A

Characterization of the binding of sulfonylurea drugs to HSA by high-performance affinity chromatography

(2010) K.S. Joseph et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Bioaffinity detection of pathogens on surfaces

(2010) Alastair W. Wark et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Synthesis and characterization of liquid chromatographic columns containing the immobilized ligand binding domain of the estrogen related receptor α and estrogen related receptor γ

(2010) M. Sanghvi et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Protein Microarrays: Novel Developments and Applications

(2010) Luis Berrade et al.   PHARMACEUTICAL RESEARCH

Next Generation Chemical Proteomic Tools for Rapid Enzyme Profiling

(2009) Mahesh Uttamchandani et al.   ACCOUNTS OF CHEMICAL RESEARCH

Applications of Protein Biochips in Biomedical and Biotechnological Research

(2009) Dirk Weinrich et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Living-Cell Microarrays

(2009) Martin L. Yarmush et al.   Annual Review of Biomedical Engineering

Immobilization of biomolecules on nanostructured films for biosensing

(2009) José R. Siqueira et al.   BIOSENSORS & BIOELECTRONICS

Novel trends in high-throughput screening

(2009) Lorenz M Mayr et al.   CURRENT OPINION IN PHARMACOLOGY

Studies of imipramine binding to human serum albumin by high-performance affinity chromatography

(2009) Michelle J. Yoo et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Biointeraction analysis by high-performance affinity chromatography: Kinetic studies of immobilized antibodies

(2009) Mary Anne Nelson et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Design of high-density antibody microarrays for disease proteomics: Key technological issues

(2009) Carl A.K. Borrebaeck et al.   Journal of Proteomics

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

The preparation and development of cellular membrane affinity chromatography columns

(2009) Ruin Moaddel et al.   Nature Protocols

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Lectin microarray

(2009) Shen Hu et al.   Proteomics Clinical Applications

Assaying Small-Molecule−Receptor Interactions by Continuous Flow Competitive Displacement Chromatography/Mass Spectrometry

(2008) Jai Sharma et al.   ANALYTICAL CHEMISTRY

Solid-phase assays for small molecule screening using sol-gel entrapped proteinsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.

(2008) Julie M. Lebert et al.   Biochemistry and Cell Biology

Functional characterization of PorB class II porin from Neisseria meningitidis using a tethered bilayer lipid membrane

(2008) Sachin R. Jadhav et al.   BIOSENSORS & BIOELECTRONICS

Small-molecule microarrays as tools in ligand discovery

(2008) Arturo J. Vegas et al.   CHEMICAL SOCIETY REVIEWS

Recent Advances in Controlled Immobilization of Proteins onto the Surface of the Solid Substrate and Its Possible Application to Proteomics

(2008) Kazuhiro Nakanishi et al.   Current Proteomics

MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays

(2008) S. C. Popescu et al.   GENES & DEVELOPMENT

Preparation of a high-performance multi-lectin affinity chromatography (HP-M-LAC) adsorbent for the analysis of human plasma glycoproteins

(2008) Majlinda Kullolli et al.   JOURNAL OF SEPARATION SCIENCE

Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology

(2008) S WANG et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Epidermal Growth Factor Receptor System in Skin Repair and Inflammation

(2007) Saveria Pastore et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pharmacokinetics in Drug Discovery

(2007) Ana Ruiz-Garcia et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Deorphanisation of G protein-coupled receptors: A tool to provide new insights in nervous system pathophysiology and new targets for psycho-active drugs

(2007) Davide Lecca et al.   NEUROCHEMISTRY INTERNATIONAL