Cell-based apoptosis assays in oncology drug discovery

Discovery of 4-Aryl-4H-Chromenes as Potent Apoptosis Inducers Using a Cell- and Caspase-Based Anti-Cancer Screening Apoptosis Program (ASAP): SAR Studies and the Identification of Novel Vascular Disrupting Agents

(2012) Sui Cai et al.   Anti-Cancer Agents in Medicinal Chemistry

Pharmacophore modeling study based on known Spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors

(2009) Huan-Zhang Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aurora kinase inhibitors: a new class of drugs targeting the regulatory mitotic system

(2009) José Alejandro Pérez Fidalgo et al.   Clinical & Translational Oncology

Polo-like kinase inhibitors: an emerging opportunity for cancer therapeutics

(2009) Puneet Chopra et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Nuclear cyclin D1: An oncogenic driver in human cancer

(2009) Jong Kyong Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Kinase Inhibitor Data Modeling and de Novo Inhibitor Design with Fragment Approaches

(2009) Michal Vieth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery ofN-(4-Methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a Potent Apoptosis Inducer and Efficacious Anticancer Agent with High Blood Brain Barrier Penetration

(2009) Nilantha Sirisoma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1

(2009) Valerie Hindie et al.   Nature Chemical Biology

The rise of fragment-based drug discovery

(2009) Christopher W. Murray et al.   Nature Chemistry

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure–activity relationships of the 1- and 3-positions

(2008) William Kemnitzer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective activation of apoptosis by a novel set of 4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1H)-quinolinones through a Myc-dependent pathway

(2008) Gisela Claassen et al.   CANCER LETTERS

Design of Phenotypic Screens for Bioactive Chemicals and Identification of their Targets by Genetic and Proteomic Approaches

(2008) David Schriemer et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Drugs and their molecular targets: an updated overview

(2008) Yves Landry et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases

(2007) Ruth Brenk et al.   ChemMedChem