Multiple Lupus-AssociatedITGAMVariants Alter Mac-1 Functions on Neutrophils

Complement Receptor 3 Influences Toll-like Receptor 7/8-Dependent Inflammation

(2013) Joanne H. Reed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SDF-1α (CXCL12) regulation of lateral mobility contributes to activation of LFA-1 adhesion

(2012) Xing Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Thers1143679(R77H) lupus associated variant ofITGAM(CD11b) impairs complement receptor 3 mediated functions in human monocytes

(2012) Benjamin Rhodes et al.   ANNALS OF THE RHEUMATIC DISEASES

Human Lupus Serum Induces Neutrophil-Mediated Organ Damage in Mice That Is Enabled by Mac-1 Deficiency

(2012) F. Rosetti et al.   JOURNAL OF IMMUNOLOGY

Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis

(2011) K. Zen et al.   BLOOD

A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

(2011) Matthew MacPherson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of neutrophils in SLE: untangling the NET

(2011) Nick Warde   Nature Reviews Rheumatology

IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis

(2011) J. M. Kelley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Affinity, lateral mobility, and clustering contribute independently to β2-integrin-mediated adhesion

(2010) Tao Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pathways: Strategies for susceptibility genes in SLE

(2010) James M. Kelley et al.   AUTOIMMUNITY REVIEWS

CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions

(2010) G. D. ROSS et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai

(2009) Wanling Yang et al.   HUMAN MOLECULAR GENETICS

Evaluation of imputation-based association in and around the integrin- -M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE)

(2009) S. Han et al.   HUMAN MOLECULAR GENETICS

Outside-In Signal Transmission by Conformational Changes in Integrin Mac-1

(2009) C. T. Lefort et al.   JOURNAL OF IMMUNOLOGY

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

(2008) Swapan K Nath et al.   NATURE GENETICS

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE